Protein
E3 ubiquitin-protein ligase msl-2
Organism
Drosophila melanogaster
Function
The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-2 is required for translation and/or stability of msl-1 in males. In complex with msl-1, acts as an E3 ubiquitin ligase that promotes ubiquitination of histone H2B.
Similarity
Belongs to the MSL2 family.
Sequence
MAQTAYLKVTRIAMRSASNLSKRRVEELNSGLGELRQLLSCVVCCQLLVDPYSPKGKRCQHNVCRLCLRGKKHLFPSCTQCEGCSDFKTYEENRMMAAQLLCYKTLCVHLLHSALFGELAGMRPQVARELVPRIKLPPKTTQEFIREGSNISDTFDIFLPQPDLPFLKDMPTSLPAETPPTSAVTTPELPYDHHLNISDIEAEAAATAEQGHFSPLPLLPTGSRMGMLSHAGQIVIATESSESGFMDQAWTDQVDLSGTVSVSKYTNSGNNFAVSYVMPTSATTKFDPQELQIGQVVQMADSTQLAVLAAVEETVETSTQLTVLSTTVEETVETSTQLEVLTSAEEPNEISDQLANLQVEESDEALVEETVEEAEGTSIPSEVVAEHMEEDQHLDVHTSQSPTQTEMEEAVEEHVATKTQLGHVQTELQDAESLQKDFEDAKAAAEEAKEKEKDLHAISAELQKEDSDEPTLKRKRTRTLKASQAAKIEPVPSEVKTKVQSGKGALRRIRGKDKEEKVKPPKPKCRCGISGSSNTLTTCRNSRCPCYKSYNSCAGCHCVCCKNPHKEDYVESDEDDDLEDFEMPKDVPEPMTQSEEPVVAEPRQEENSMAPPDSSAPISLVPLNNLQQSQHPLVLVQNEKGEYQGFNIFQGSKPLDPVTVGFTIRVQLQHTDGFGSLPQYAYIMPTIDPPNPPAPSLSPPPPPAPDREVIEPPAKKFRTSRTRRGRANFSALDTVDELVSGGSRSNSAAGDRSSATDNAHSLFEEIMSGSDDL