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msh-3

Gene
msh-3
Protein
DNA mismatch repair protein msh-3
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
1145 amino acids
Function
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh-2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh-3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
Similarity
Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
Mass
125.692 kDa
Sequence
MAGPSRLPDKKQASISSFFTPRNTSPLVNLSQNASKKPPPAESKSSKSTSSRKRPEPQTDDSEDDVPRDAKRRRSNGPSAATDTEDAVASLKLSSSSRTERYALNSSRPSQDEQEKEEDVAERKKKEELHRKFVKKLGHPDSMFSYRQRDTESAAVEGEGEEGEDDEEEPAPKTTAKKKGAKTGKLTPMELQFLEIKRKHMDTLLIVEVGYKFRFFGEDARIAARELSIVCIPGKFRYDEHPSEAHLDRFASASIPVHRLPVHAKRLVAAGYKVGVVRQIETAALKKAGDNRNAPFVRKLTNVYTKGTYIDETGELDQPGETTGASSGGYLLCLTETPAKGMGTDEKVNVGIIAVQPATGDIIYDEFEDGFMRREIETRLLHISPCEFLIVGDLSKATDKLIQHLSGSSTNVFGDKSRVERVPKSKTMAAESYSNVTDFYAGKAKDSDERSAALLNKVLKLPEAVMICLSAMITHLTEYGLQHIFDLTKYFQSFSTRQHMLINGTTLESLEVYRNATDHSEKGSLLWALDKTHTRFGQRLLRKWIGRPLLDQQRLEERVSAVEELLNNQSTAKVDKLVNMLKSIKADLERSLIRIYYGKCTRPELLSTLQTLQKISFEYARVKSPADTGFSSTLLTSAIMTLPSISPMVTAHLSKINAEAARKDDKYAFFLEQHETEDISEHKLGIAAVEQDLDEHRSEAAKDLGKKVPVNYVTVAGIEYLIEVPNTDLKRVPASWAKISGTKKVSRFHTPTVLRLIAERDQHKESLASACDQAFSDLLSQIAGEYQPLRDAVSSLSTLDCLLSLSTVAALPGYTKPTFLPSSHPSFLSITEGRHPIAEHLLPNGYIPFTMSLGTLSSSASSPDPNPTSPSGKPALAQLITGPNMGGKSSYTRAVALLVLLAQIGSFVPATSMSLTLSDAIFTRMGARDNLFKGESTFMVEVSETAAILRQATPRSLVVLDELGRGTSTHDGRAIAGAVLEYVVRDVGCLMLFVTHYQDLAGVAEGLTVGEGEEKRRGVECVHMRFASNKSRTSMDDDAMEVDGDGDGQEGAGADKDEEEEITFLYDLAPGVAHRSYGLNVARLARIPRKVLEVAARKSSELEKEVRAKRIKGAMGLVGGVLYGGGAPGDQEEKLEQLVGLVEQL