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mscS

Gene
mscS
Protein
Small-conductance mechanosensitive channel
Organism
Escherichia coli O157:H7
Length
286 amino acids
Function
Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage; as the membrane is depolarized, less tension is required to open the channel and vice versa. The channel is characterized by short bursts of activity that last for a few seconds.
Similarity
Belongs to the MscS (TC 1.A.23) family.
Mass
30.896 kDa
Sequence
MEDLNVVDSINGAGSWLVANQALLLSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDATVADFLSALVRYGIIAFTLIAALGRVGVQTASVIAVLGAAGLAVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGTVLSVQIFSTTMRTADGKIIVIPNGKIIAGNIINFSREPVRRNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMTVRLNELGASSINFVVRVWSNSGDLQNVYWDVLERIKREFDAAGISFPYPQMDVNFKRVKEDKAA

Gene
mscS
Protein
Small-conductance mechanosensitive channel
Organism
Escherichia coli (strain K12)
Length
286 amino acids
Function
Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage; as the membrane is depolarized, less tension is required to open the channel and vice versa. The channel is characterized by short bursts of activity that last for a few seconds.
Similarity
Belongs to the MscS (TC 1.A.23) family.
Mass
30.896 kDa
Sequence
MEDLNVVDSINGAGSWLVANQALLLSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDATVADFLSALVRYGIIAFTLIAALGRVGVQTASVIAVLGAAGLAVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGTVLSVQIFSTTMRTADGKIIVIPNGKIIAGNIINFSREPVRRNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMTVRLNELGASSINFVVRVWSNSGDLQNVYWDVLERIKREFDAAGISFPYPQMDVNFKRVKEDKAA

Gene
mscS
Protein
Small-conductance mechanosensitive channel
Organism
Edwardsiella ictaluri (strain 93-146)
Length
286 amino acids
Function
Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage; as the membrane is depolarized, less tension is required to open the channel and vice versa. The channel is characterized by short bursts of activity that last for a few seconds.
Similarity
Belongs to the MscS (TC 1.A.23) family.
Mass
30.648 kDa
Sequence
MKELDVVDGIQSAGGWIVRNQDLLLGYAVNLVAAVVILIIGSLIARGISTTLIRLLKARGLDVTVVHFLAAMVRYAILAFTIIAALGRLGVQTTSVIAVLGAAGLAVGLALQGSLSNFAAGVLLVLFRPFRAGEVVDLGGVTGTVREVQIFSTTLATADNKVIVVPNGKIIAGNIINFSREPKRRIDIIVGVAYDADIDVVKRVLGDVVAADTRILHDDGVTIRLNEMAASSLNFVVRVWGNNADYWAIYFDLMENFKRALDANNIGIPFPQMDVHLYQAVKARAE

Gene
mscS
Protein
Small-conductance mechanosensitive channel
Organism
Shigella flexneri
Length
286 amino acids
Function
Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage; as the membrane is depolarized, less tension is required to open the channel and vice versa. The channel is characterized by short bursts of activity that last for a few seconds.
Similarity
Belongs to the MscS (TC 1.A.23) family.
Mass
30.896 kDa
Sequence
MEDLNVVDSINGAGSWLVANQALLLSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDATVADFLSALVRYGIIAFTLIAALGRVGVQTASVIAVLGAAGLAVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGTVLSVQIFSTTMRTADGKIIVIPNGKIIAGNIINFSREPVRRNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMTVRLNELGASSINFVVRVWSNSGDLQNVYWDVLERIKREFDAAGISFPYPQMDVNFKRVKEDKAA

Gene
mscS
Protein
Small-conductance mechanosensitive channel
Organism
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)
Length
282 amino acids
Function
Mechanosensitive ion channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Has high selectivity for anions, and may contribute to resistance to hypoosmotic shock.
Similarity
Belongs to the MscS (TC 1.A.23) family.
Mass
32.034 kDa
Sequence
MWADIYHKLVEIYDIKAVKFLLDVLKILIIAFIGIKFADFLIYRFYKLYSKSKIQLPQRKIDTLTSLTKNAVRYIIYFLAGASILKLFNIDMTSLLAVAGIGSLAIGFGAQNLVKDMISGFFIIFEDQFSVGDYVTINGISGTVEEIGLRVTKIRGFSDGLHIIPNGEIKMVTNLTKDSMMAVVNIAFPIDEDVDKIIEGLQEICEEVKKSRDDLIEGPTVLGITDMQDSKLVIMVYAKTQPMQKWAVERDIRYRVKKMFDQKNISFPYPRTTVILSEKKTN

Gene
mscS
Protein
Small-conductance mechanosensitive channel
Organism
Wigglesworthia glossinidia brevipalpis
Length
280 amino acids
Function
Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.
Similarity
Belongs to the MscS (TC 1.A.23) family.
Mass
31.701 kDa
Sequence
MNIYKEIDNASNWISDNHILFIKYISNIILSLIILIVGYSASKVTQKIIKNFMIKKNIDIIISEFFCSIIKYSILIFTIVTSLGCIGIQTTSIIAVIGAAGIAIGLALQGSLSNFAAGVLLVTLRYFRTGDYVNLCGVKGKIKTVQIFCTKIKTKDGKIIIIPNNKIISSNIINYSEELHRLMEVIISTEYTSDIKNVKEIIIDVLKKETRIVKEKKITVRLKNLGESSLDFLVRGWVYKKELKQTTSDILEKIKIELDKNKINIPYKQIDVNLKYSKEK

Gene
mscS
Protein
Small-conductance mechanosensitive channel
Organism
Helicobacter pylori
Length
274 amino acids
Function
Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.
Similarity
Belongs to the MscS (TC 1.A.23) family.
Mass
30.402 kDa
Sequence
MDEIKTLLVDFFPQAKHFGIILIKAVIVFCIGFYFSFFLRNKTMKLLSKKDEILANFVAQVTFILILIITTIIALSTLGVQTTSIITVLGTVGIAVALALKDYLSSIAGGIILIILHPFKKGDIIEISGLEGKVEALNFFNTSLRLHDGRLAVLPNRSVANSNIINSNNTACRRIEWVCGVGYGSDIELVHKTIKDVIDTMEKIDKNMPTFIGITDFGSSSLNFTIRVWAKIEDGIFNVRSELIERIKNALDANHIEIPFNKLDIAIKNQDSSK