mqnB

Futalosine hydrolase

244 amino acids

Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Cannot directly use aminodeoxyfutalosine (AFL) as a substrate.

Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.

24.588 kDa

MSVKRLIITAVAAEADAVASGLDGAQPHPQGSANVRHTATADILVAGVGSAAAAAATAAALARRHYSLVICTGIAGGIGIAGIGDIVVADAVHPADLGAMSPDGFIPLEHLGIATTANAIDPPVVEELTGPLRYAGLAPVIGGILTVNTVTGTDAHADDLRRRYPGAVAEAMEGYGVAVAATRAGVRYGELRVVSNRVGRRDRRAWDIPGALRRLEHAFAALGAAWCNDGSGQAAAREIDGGCP

mqnB

Futalosine hydrolase

235 amino acids

Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Does not accept aminodeoxyfutalosine (AFL) as a substrate.

Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.

23.448 kDa

MHLLVATAVSVERDAVARAFPAPGTEVSRPGITLHRLPDGWDLLAAGVGPARAAASTAAALTAAALDGRPYDLVVSAGIGGGFAPEAPVGSLVVADAITAADLGAETADGFLPVTDLGFGTVTHLPPAPLVRAAAEATGARPGTVLTGSTVTGTAARAALLRERHPGALAEAMEGFGVAEAAAAHGVPVLELRAVSNPVGPRDRAAWRIGEALAALTDAVGKLAPVLESWKPHER

mqnB

Futalosine hydrolase

225 amino acids

Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Is highly specific to futalosine since it does not accept aminodeoxyfutalosine (AFL), or any structurally related nucleotides and nucleosides as substrate.

Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.

23.829 kDa

MWLLLSPTRLEAPFLEGEPFAFLAWRGLKGTGFVYLETGIGKVNAAMALAAYAARNPVEKALLFGLAGAYPGGPSLGEAVLVEEEVEADLGLKEGLAPLGFPALALGERRYFNRFPLDPGLTGELARGLGLKVAVGLTRDLVSETPEEALALARRWGASLENMEGAAFARACLALGVRGAELRALSNPAGVRDKAHWRTKEALSALARAVRRLLAEEGGARRPPG