Protein
Futalosine hydrolase
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Function
Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Is highly specific to futalosine since it does not accept aminodeoxyfutalosine (AFL), or any structurally related nucleotides and nucleosides as substrate.
Similarity
Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.
Sequence
MWLLLSPTRLEAPFLEGEPFAFLAWRGLKGTGFVYLETGIGKVNAAMALAAYAARNPVEKALLFGLAGAYPGGPSLGEAVLVEEEVEADLGLKEGLAPLGFPALALGERRYFNRFPLDPGLTGELARGLGLKVAVGLTRDLVSETPEEALALARRWGASLENMEGAAFARACLALGVRGAELRALSNPAGVRDKAHWRTKEALSALARAVRRLLAEEGGARRPPG