Function
Involved in gene silencing (PubMed:22555433). Plays a role in germline RNA interference (RNAi), and in particular, the silencing of endogenous small interfering RNA (endo-siRNA) target genes (PubMed:28535375). May play a role in heterochromatin localization and condensation, and the siRNAi-directed trimethylation of 'Lys-9' of histone H3 in hermaphrodite X chromosomes (PubMed:28535375). Promotes transgenerational epigenetic inheritance and germline immortality (PubMed:28535375, PubMed:28533440).
Sequence
MPNDTNGDDYKKLEKASVNLNFLKSNSHTHIGPLSAIAELVDNAYDADARDLHIDFLDINNEQFLELRDDGLGMAREEALHAITFGHSAKCSYKIGRYGNGLKSGAFHLGRELLLVTKKDGIITALLISHRFHEDQGLTNSVFVPCPSFDLDGIPICQTESEKDRFNLEMKIIGKYAPLGSRTLAELADKITGSTGTIIIIGNLRRSVTGELAINTTKDPTDIIVDSGEENKPWRESLRKYLEFIYLKPRMRIHVRGEQVLPKRISENWIAKKQQLISGDQFTAAYNKILDEKNETVKKCEEEKALVMSEIGGTNYTSVRREDRANQKSLRLRVDTSQKNLDSAIADRDAFKKEGKSEKSFHLNMGIETKDRSNNGIHFYINNRLILWGNKEAKFFSKFANSIGISMFLSLDYSLFSAAQNKQGFDHVKDFQVLVRKCNDALRDYSMYLEKSWIPTHLKNTWNVRIYEGDDVWAVLWGVYGYNNTTSTTCVQTHDSARDQVMWTTCGIWKLCQMCRTWIKASRPNEIVGSNDDFFCCENVNHHGCRTIVAEDNDFSKLPEKYDHILPQKRLTNSAPSSSDSQNSIRSASSCSSSSRLLNVAKIESHERIHSSTGGHRLGESFSTTSVKMEPIPNNAHDSHIAEVQRRHSTGRAISPAVSEISRRAGTAPSSQLDMIMGEESDESQEALTIRAPRQRAKRPIERVSRRNRRDQSDDDSDSENEERYATAPKKSKVKGKAVVRAPKMTREKWLEEMLNQFLTAHGEQPLPKNGQRDFDPTNIVEQTSRRNFKNNQRIVDAQQAIMRQIGSVLDHLKRNPTHNFKIPASGTVEEKLKNIEHQIKGKKK