mom-1

Protein-serine O-palmitoleoyltransferase porcupine

444 amino acids

Key regulator of the Wnt signaling pathway that mediates lipid modification of Wnt proteins. Acts as a protein-serine O-palmitoleoyltransferase that catalyzes the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors. Has a role in cell specification, specifically in blastomere signaling. Involved in cytosketetal polarity. Required for the orientation of mitotic spindle axis.

Belongs to the membrane-bound acyltransferase family. Porcupine subfamily.

51.361 kDa

MDHHLDPNLDNLFEMYGESVEECATQVANGTLLTLLQMLVLVWMFFLVWRLSLPPRIQTFLHIAMTTLTVAWFSPKKLESVMIFHTFSLISLFCAVQKLNGYRILGLNIMLLIALQNICSRANADDYFLTLRGVLMMHIMRLSTASFAIVDSNVRSISFDQLTLYLEYIYFPPFIIFGPYVTFDQFVKMREKKWTRFEEQLGVFVQGSVLIFIGITLAIISSCYVDFFEPGSQFVEDALTAMSFRCSHYFICLSTQAFAMFLGSKIVVANPVNIEFSRSTLQTVSEWNRPFHTYLHENIFKRRFFQSTALNVLLTFAVSALLHARDYQMWLTLLALGFIAYSETVFRKRIADRFSMCVAAKPCSVRANRRICKHKHASFSKRVLIINLFFMILSMYHLVFTGMTFTDDYAAIGYPFSHTWTIWGTHYYSSFIVSFAFLALSKII

mom-1

Protein-serine O-palmitoleoyltransferase porcupine

442 amino acids

Key regulator of the Wnt signaling pathway that mediates lipid modification of Wnt proteins (PubMed:10444600, PubMed:15020416, PubMed:9288750). Acts as a protein-serine O-palmitoleoyltransferase that catalyzes the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins (By similarity). Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors (By similarity). Has a role in cell specification, specifically in blastomere signaling (PubMed:10444600, PubMed:15020416, PubMed:9288750). Involved in cytosketetal polarity (PubMed:10444600, PubMed:15020416, PubMed:9288750). Required for the orientation of mitotic spindle axis (PubMed:9288749, PubMed:10444600, PubMed:15020416, PubMed:9288750).

Belongs to the membrane-bound acyltransferase family. Porcupine subfamily.

50.874 kDa

MDNGHGYEEFELLEDGSLGECSTQVANATFLTISKLICLVVAFKFIKHIPISTTVRVYVHVFASTFTVMWFSRNHLQSAIIYNMFSLISLALAIKQFSGYIILAGNISLLIALQNFCRHYRSEDYFLSIRGILMIHIMRLTTVAFNLEKANSNKFRFVQFSSYVEYIYFPPFIIFGPYLSFEQFFKMRDKKWTGSENELGFIIQSLLAIFNAITLAIISSCHFEFFEPSSQFMEDALTAMSFRFSHYFVCLSTQAFVLMLGSDVVVANPLNIEFSRSTLQTVSEWNKPFHTFLHENIFKRRLFNSTACNVFFTFAVSSLLHGLDFQMTITLLALGFIAYSETVFRKRLSARYSMCVAAKACPVRSNSLSCKHRHSNKTGRALIINLFFLMLSMYHLVFTGMTFTDDYSAIGYPFDHAWKIWGSHYYSSFMISFLFLALSKII