Protein
Maintenance of mitochondrial morphology protein 1
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria (By similarity). Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria (PubMed:10982393). The mdm12-mmm-1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The mdm10-mdm12-mmm-1 subcomplex further acts in the TOM40-specific pathway after the action of the mdm12-mmm-1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids (By similarity).
Similarity
Belongs to the MMM1 family.
Sequence
MADICPSRSEPTLSFTQGLILGQLSVVLLLAAFIKFFIFGDPPSPEVVASIRATDRRSRTLAHKKSILSLRETNALQLVQNPALNKKHVLRPGPPILTIGSILSKTYYKVDSHQPESLDWFNVLIAQTIAQFRSDAQHDDAILSSLSKALNGTARPDFLDEIKVTELSLGEDFPIFSNCRIIPVDEDGLSFGTGKAFDANMATREGARLQARMDVDLSDMITLAVETKLLLNYPKRLSAVLPVALAVSVVRFSGTLSISFIPSNPSNNEPAKMIFTFLDDYRLDFSIRSLLGSRSRLQDVPKIAQLVESRLHRWFDERCVEPRFQEIALPNMWPRKKNTRGGDETISDVERSMSKAKGVDIAKDVREEARKEIEAEAHGGADRVPDSLRYRHRPRADEEFPGAGSMPGSMPGSMP