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mlrA

Gene
mlrA
Protein
HTH-type transcriptional regulator MlrA
Organism
Escherichia coli (strain K12)
Length
243 amino acids
Function
Activates transcription of csgD, the master regulator of biofilm formation, by binding to its promoter region (PubMed:11489123, PubMed:20874755). Also controls the transcription of cadC and ibaG (PubMed:20874755). Part of a signaling cascade that regulates curli biosynthesis. The cascade is composed of two c-di-GMP control modules, in which c-di-GMP controlled by the DgcE/PdeH pair (module I) regulates the activity of the DgcM/PdeR pair (module II), which in turn regulates activity of the transcription factor MlrA (PubMed:23708798).
Mass
28.046 kDa
Sequence
MALYTIGEVALLCDINPVTLRAWQRRYGLLKPQRTDGGHRLFNDADIDRIREIKRWIDNGVQVSKVKMLLSNENVDVQNGWRDQQETLLTYLQSGNLHSLRTWIKERGQDYPAQTLTTHLFIPLRRRLQCQQPTLQALLAILDGVLINYIAICLASARKKQGKDALVVGWNIQDTTRLWLEGWIASQQGWRIDVLAHSLNQLRPELFEGRTLLVWCGENRTSAQQQQLTSWQEQGHDIFPLGI

Gene
mlrA
Protein
HTH-type transcriptional regulator MlrA
Organism
Salmonella typhimurium (strain SL1344)
Length
243 amino acids
Function
Transcriptional activator of csgD, which is required for production of the curli (AgF).
Mass
27.902 kDa
Sequence
MALYTIGEVALLCDINPVTLRAWQRRYGLLKPQRTDGGHRLFNDADIDRIREIKRWIDNGVQVSKVKVLLSSDSSEQPNGWREQQEILLHYLQSSNLHSLRLWVKERGQDYPAQTLTTNLFVPLRRRLQCQQPALQALLGILDGILINYIALCLASARKKQGKDALVIGWNIHDTTRLWLEGWVASQQGWRIDVLAHSLSQFRPELFDGKTLLVWCGENQTLAQQQQLLAWRAQGRDIHPLGV

Gene
mlrA
Protein
HTH-type transcriptional regulator MlrA
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
243 amino acids
Function
Transcriptional activator of csgD, which is required for production of the curli (AgF).
Mass
27.902 kDa
Sequence
MALYTIGEVALLCDINPVTLRAWQRRYGLLKPQRTDGGHRLFNDADIDRIREIKRWIDNGVQVSKVKVLLSSDSSEQPNGWREQQEILLHYLQSSNLHSLRLWVKERGQDYPAQTLTTNLFVPLRRRLQCQQPALQALLGILDGILINYIALCLASARKKQGKDALVIGWNIHDTTRLWLEGWVASQQGWRIDVLAHSLSQFRPELFDGKTLLVWCGENQTLAQQQQLLAWRAQGRDIHPLGV

Gene
mlrA
Protein
HTH-type transcriptional regulator MlrA
Organism
Escherichia coli (strain K12)
Length
243 amino acids
Function
Activates transcription of csgD, the master regulator of biofilm formation, by binding to its promoter region (PubMed:11489123, PubMed:20874755). Also controls the transcription of cadC and ibaG (PubMed:20874755). Part of a signaling cascade that regulates curli biosynthesis. The cascade is composed of two c-di-GMP control modules, in which c-di-GMP controlled by the DgcE/PdeH pair (module I) regulates the activity of the DgcM/PdeR pair (module II), which in turn regulates activity of the transcription factor MlrA (PubMed:23708798).
Mass
28.046 kDa
Sequence
MALYTIGEVALLCDINPVTLRAWQRRYGLLKPQRTDGGHRLFNDADIDRIREIKRWIDNGVQVSKVKMLLSNENVDVQNGWRDQQETLLTYLQSGNLHSLRTWIKERGQDYPAQTLTTHLFIPLRRRLQCQQPTLQALLAILDGVLINYIAICLASARKKQGKDALVVGWNIQDTTRLWLEGWIASQQGWRIDVLAHSLNQLRPELFEGRTLLVWCGENRTSAQQQQLTSWQEQGHDIFPLGI

Gene
mlrA
Protein
HTH-type transcriptional regulator MlrA
Organism
Salmonella typhimurium (strain SL1344)
Length
243 amino acids
Function
Transcriptional activator of csgD, which is required for production of the curli (AgF).
Mass
27.902 kDa
Sequence
MALYTIGEVALLCDINPVTLRAWQRRYGLLKPQRTDGGHRLFNDADIDRIREIKRWIDNGVQVSKVKVLLSSDSSEQPNGWREQQEILLHYLQSSNLHSLRLWVKERGQDYPAQTLTTNLFVPLRRRLQCQQPALQALLGILDGILINYIALCLASARKKQGKDALVIGWNIHDTTRLWLEGWVASQQGWRIDVLAHSLSQFRPELFDGKTLLVWCGENQTLAQQQQLLAWRAQGRDIHPLGV

Gene
mlrA
Protein
HTH-type transcriptional regulator MlrA
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
243 amino acids
Function
Transcriptional activator of csgD, which is required for production of the curli (AgF).
Mass
27.902 kDa
Sequence
MALYTIGEVALLCDINPVTLRAWQRRYGLLKPQRTDGGHRLFNDADIDRIREIKRWIDNGVQVSKVKVLLSSDSSEQPNGWREQQEILLHYLQSSNLHSLRLWVKERGQDYPAQTLTTNLFVPLRRRLQCQQPALQALLGILDGILINYIALCLASARKKQGKDALVIGWNIHDTTRLWLEGWVASQQGWRIDVLAHSLSQFRPELFDGKTLLVWCGENQTLAQQQQLLAWRAQGRDIHPLGV