Function
Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer (By similarity). Required together with sqv-5 for the biosynthesis of chondroitin (PubMed:15485872). Chondroitin is involved in organogenesis of the vulva, maturation of the gonad, and neural development (PubMed:15485872, PubMed:16982046). May have a specific role in unc-6/netrin-mediated dorsal guidance of gonadal distal tip cells (PubMed:16982046). Glycosyltransferase activity is weak (PubMed:15485872).
Sequence
MVGGGRTGIHLLLGFLIGAALALFFFSSTPSIDLTSSLAAFTSCQNQETETNVLEPSALEKGRVYKDLSEHWIVHQDDMPAPPHNQDATPKVTRTRFAATELGTRERVMAAVMAESALALSINATLGRHVPRVHLFADSSRIDNDLAQLTNLSPYKLNGQKTHSMVLGLLFNMTVHNNYDWFLLAKDSTYINPFVLLRMIDTMNWNEPVVMGEAAEDGSGRCRLDTGMLLSQPAMHALMNNRNACNNFALAADDDQLAFEKCIQIATNLTCKPLHQGVRYEVWRGAERADSPAAHDSIEDWKHSPAFKRALAVPRLLSDADASALHDYFVRVEMQRADREIIKMEAELSRLAEQEARETGEAISWPPALPPYAKPPNRYQVSTWEYFTMTELFRSEPNQNVRRLEGKDFDDVAEVVVAARQQVESEEPELEFVQLRNGYRVFDPRRGMDYMVDLTYRKTVNEMPEVDNRFESDNEAAHEESLKEIVVERRVHVSRMIASTQLMNQAPYVKEDTDVTVVIPVASEKDVLPARKLLARQARLCLFPTEEARKTRMVVAVFPLIESRSVTAITNDMEELKRRCKRSLLETDVLPVHPAVSTEGKGTAAAAALDDAVDRYGANTIYLLLSPHADVQKEFFDRARINTIKHYQVFFPVPFVEYHPTISGMEMTEKEEKETPTEQAREAALSRLRDGVEPKRKRTLIVQKEHGRFDSQDFSCFAVYGVDYVTARAKFGQNERRNDLISAFLGQDSIHVLRAVEPTLRIRYHKRSCDMESIDTEDIARCLDSKKENVAAKDQLAKLLFHEK