midn-b

Gene

midn-b

Protein

Midnolin-B

Organism

Xenopus laevis

Length

451 amino acids

Function

Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.

Mass

49.213 kDa

Sequence

MEQQPSVPRSCTNVARETPMNLNIQSTTGTRYELSVPLNETVDGLKRRISQRLKVPKERLTLLHRETRLSSGKLQDLGISDGSRLTLLPSVEAGLMSQMSRPEQSVMQALESLTETQVNDFLSGRSPLTLALRVGDHMMFVQLQLAAQQSGGSHLQHRHVITRGADAGAPPQYRTLHTSTSALSHLASCTPGSTPPTTLSPTSSTHCDAPHSSPLTTSVFRSHGEGVSPCAEQVPCSTRGTEGTSSSPSSRSRKPGAIIESFVNHAPGVFSGTFSGTLHPHCQDGAGRPRRDIGTILQILNDLLSATRHYQGMPPSLTTLRCHTQCASQARNAKATSPQSTGPQQTTHPVGHCQAQTRTCKPSGDRLRQTENRATRCKVERLQLLMHQKRLRRKARRDSRAPYHWMPTRKSSRTSSNSSTSSGEGSLEIDFEDSLWKPDVKAELNSEFVVA

Protein

Midnolin-B: midn-b