midn

Gene

midn

Protein

Midnolin

Organism

Danio rerio

Length

509 amino acids

Function

Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.

Mass

54.873 kDa

Sequence

MDQHPSARSCSSRGAAPSCESVSGEPPMNLYIHSTTGTRFELSLPAEETVEGLKRRLSQRLKVPKERLALLHKETRLSSGKLQDLGITDGSKLTLVPTVEAGLMSQASRPEQSVMQALESLTETQVSDFLSGRSPLTLALRVGDHMMFVQLQLAAQPSGGPQLQHRHLISRGSSEGTTGLSHGASGSASGMARVSHNPHPHHPHQHPHHPNTTLPSNPAAFPPSPSIPSIPPMYSTSASGHCSPPPQPSQLPGSFLHSQQPSSACAPSPSSPSPAASCPEASCSAKTSGNCNTPLRSRKPGAIIESFVNHAPGVFSGTFSGTLHPNCQDSTGRPRRDIGTILQILNDLLSATRHYQGMPPSLTQLRYQTQCTSPNSPAPSPPPSPPHTTGLTGLPTTVPSETQPTLHPLVQCQSQIRMCKPPGDRLRQTENRATRCKVERLQLLMQQKRLRRKARRDSRAPYHWLPNRKAGRSNSNSSMSSEGSLDLDFEDSVWKPDVKADMKSEFIMA

Protein

Midnolin: midn

Gene

Midn

Protein

Midnolin

Organism

Rattus norvegicus

Length

505 amino acids

Function

Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4 (By similarity). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion (PubMed:24187134).

Mass

53.679 kDa

Sequence

MEPQPGGARSCRRGAPGGACELSTTAESAAPMSLAIHSTTGTRYDLSVPHDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALESLTETQPPATPGPGRAAGGGFRKYRLILFKRPWHRQGPQSPERGGERPQVSDFLSGRSPLTLALRVGDHMMFVQLQLAAQHAPLQHRHVLAAAAAAAAAARGDSSIATPVSSPCRPVSSAARVPPVSSSPSSPVSPSPVTAGTFQSHAASTTCPEQTDCSPPASSNTTSTPGSSPTPRSRKPGAVIESFVNHAPGVFSGTFSGTLHPNCQDSSGRPRRDIGTILQILNDLLSATRHYQGMPASLTQLRCHAQCSPASPAPDLTPKTTSCEKLATPSLLQGQSQIRMCKPPGDRLRQTENRATRCKVERLQLLLQQKRLRRKARRDARGPYHWTPSRKAGRSDSSSSGGGGSPSEATGLGLDFEDSVWKPEVNPDIQSEFVVA

Protein

Midnolin: Midn

Gene

MIDN

Protein

Midnolin

Organism

Homo sapiens

Length

468 amino acids

Function

Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.

Mass

49.213 kDa

Sequence

MEPQPGGARSCRRGAPGGACELGPAAEAAPMSLAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALESLTETQVSDFLSGRSPLTLALRVGDHMMFVQLQLAAQHAPLQHRHVLAAAAAAAAARGDPSIASPVSSPCRPVSSAARVPPVPTSPSPASPSPITAGSFRSHAASTTCPEQMDCSPTASSSASPGASTTSTPGASPAPRSRKPGAVIESFVNHAPGVFSGTFSGTLHPNCQDSSGRPRRDIGTILQILNDLLSATRHYQGMPPSLAQLRCHAQCSPASPAPDLAPRTTSCEKLTAAPSASLLQGQSQIRMCKPPGDRLRQTENRATRCKVERLQLLLQQKRLRRKARRDARGPYHWSPSRKAGRSDSSSSGGGGSPSEASGLGLDFEDSVWKPEVNPDIKSEFVVA

Protein

Midnolin: MIDN

Gene

Midn

Protein

Midnolin

Organism

Mus musculus

Length

465 amino acids

Function

Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4 (PubMed:27326929). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion (By similarity).

Mass

49.192 kDa

Sequence

MEPQPGGARSCRRGAPGGACELNTATESAAPMSLAIHSTTGTRYDLSVPHDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALESLTETQVSDFLSGRSPLTLALRVGDHMMFVQLQLAAQHAPLQHRHVLAAAAAAAAAARGDSSVATPVSSPCRPVSSAARVPPVSSSPSSPVSPSPVTAGSFRSHAASTTCPEQMDCSPPASSSSTSTPGSSPTPRSRKPGAVIESFVNHAPGVFSGTFSGTLHPNCQDSSGRPRRDIGTILQILNDLLSATRHYQGMPPSLTQLRCHAQCSPASPAPDLTPKTTSCEKLAATSSTSLLQGQSQIRMCKPPGDRLRQTENRATRCKVERLQLLLQQKRLRRKARRDARGPYHWTPSRKAGRSDSSSSGGGGGPSEATGLGLDFEDSVWKPEVNPDIQSEFVVA

Protein

Midnolin: Midn

Gene

midn

Protein

Midnolin

Organism

Xenopus tropicalis

Length

453 amino acids

Function

Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.

Mass

49.484 kDa

Sequence

MEQQPSVPRSCTNVARETPMNLNIQSTTGTRYELSVPPDETVDGLKRRISQRLKVPKERLTLLHRETRLSSGKLQDLGISDGSRLTLLPSVEAGLMSQMSRPEQSVMQALESLTETQVNDFLSGRSPLTLALRVGDHMMFVQLQLAAQQSGASHLQHRHVITRGAEAGASPQYRTLHTSTSALSHLASCTPGSTPPTTLSPTASTHRDGPHSSPLTTSVFRSHGEGVAVSPCAEQVPCSSRGTEGTSSSASSRSRKPGAIIESFVNHAPGVFSGTFSGTLHPHCQDSAGRPRRDIGTILQILNDLLSATRHYQGMPPSLTTLRCHTQCASQARNPKATSPQSSEPQQTTHPVGHCQAQTRTCKPSGDRLRQTENRATRCKVERLQLLMHQKRLRRKARRDSRAPYHWMPTRKSSRTSSNSSTSSGEGSLEIDFEDSLWKPDVKAELNSEFVVA

Protein

Midnolin: midn