Protein
Protein-methionine sulfoxide oxidase mical3a
Function
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process (By similarity).
Similarity
Belongs to the Mical family.
Sequence
MGDGGVNAVGEGVNQSHMLFDRFVQATTCKGTLKAFQELCDFLELKPNEYRVFYHKLKSKLNYWKAKALWAKLDKRASHKEYKKGRACANTKCLIIGAGPCGLRTAIELGFLGAKVVLLEKRDAFSRNNVLHLWPFTIQDLRGLGAKKFYGKFCAGAIDHISIRQLQLMLLKVALLLGIEIHVNVEFKGLIEPPEDQENERIGWRAEVHPRTHPVNELEFDVIIGADGRRNTLSGFRRKEFRGKLAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQDLREATGIDLENIVYYKDDTHYFVMTAKKQSLLEKGVILHDYADTEMLLSRANVDQKALLSYAREAADFSTNHQLPKLDFAINHYGQPDVAMFDFTCMYASENAALVRQRNGHKLLVALVGDSLLEPFWPMGTGIARGFLAAMDSAWMVRSWAHGSSPLEVLAERESIYRLLPQTTPENVSKNFSQYSVDPTTRYPNISLHQVRPNQVRHLLDTGETRDLRVDLENVVNSSTPKLTRNESIVRSSKLLNWCQRQTEGYRGVSVSDLTTSWKSGLALCALIHRYRPDLIDFESLDEKDVEKNNQLAFDVAEREFGISPIMTGKEMSVVVEPDKLSMVMYLSQFYEMFKDTVPPGENQNLSPEEKAALIASTKSPISFLSKLGQSIAISRKRNPKDKKEKELDGLGKRRKTSQAGQSEDEELQRANRDDRPSIATALAERKIDSAAAANNNNKVKSMATQLLAKFEENAPTQSTGLKRQGSFRKEFPQNIGGSDVCFFCRKRVYVMERLSAEGKFFHRSCFKCDYCGTTLRLSSYAFDVEDGKFYCKPHYCYRLSGVAQRKRPAPAAAPANAKEPQVLAVSPNTVDAPGQAITTQTPAERRPSETEVNGVTEPSVAKRLKGTPERIELENYRLSMMREEELEEVPEETLAEHNLSSVLDKATDIEEGSSSSESDMEEEDEDAEAAGPSDLGGVPWKEAVELHAKLKGESDPGADDDGLHDGDGEMDEDEEEEEDEEDEDEEEEEESSEEPCEEDDDPEAEAGSPDFEPGTEIDQEDIPSDAEAEARSRCIDEVVTLPVDNDKTESQGQVFNTAEKTSANPRELIVDVVLSPIQKPALPIEEVHEVSPVVLVKSPGARFFPEPYLPDKVKQNIPPPQSPDVKTPHSPVAQIIALSPICSQPVPQPGTASPKSPVQPQPCACSPTGNPLSPICTQSQPCNEPPSPLSTSSPVRTQPVPAVTSTPLAKPASENRTNEHLKDSTPELKKTDLIEEFWLKSAEIRKSLGLTPLERSKTAVEKSIVKTPTPESSSPKSYTPEDLSEEQKPTFTGRSIIRRINITLEGQVISPVEPKSNGSEKKDLSSSSGLGLNGSVTTSQTAASDSYNNSDSTMLTPPSSPPPPPPREEPACLQNKKSQVSWDNLLEGTEEPKSETMPIKPRTPVSPPQPKQKPVTAPVPTPRTNPPVVMRVKEPNKPRREEVRKSFVECVDEIPFADDVEDTYDDRTPDASGLEKFYTPPTSKVNRDKPPLHLALAMENGKPNIPGVSRTAKGSQHFSPEAKEIAEERMRAREKSVKSQALKDAMAKQLTKMKDSEVAKGAVAKVAWDIPETKGKSKKQSKAQKDSAVKALESKKQADTLPDRFFSTPSSKALDSSVTSSESSTGGKSKKRSSLFSPRKNKKEKKAKNERLSSTEETPPKHKSLWKAVFSGYKKDKKKKDDKSCPSTPSSSTTGDSGKKKDSPLDRSSDLRLRRNLSFSEDSDLSCDDVLERSSQKSKGDSVYVPHALAFKRSYATKKTYTEEELNAKLTRRVQKAARRQAKQEELKRLHRAQMIQRQLEQVEEKQRQLEERGVAVEKALRGEADYWGESNYSEILDLHLGGMGKKDDPKLMQEWFKLVQEKNALVRYESELMIFARELELEDRQSRLQQELRERMAIDDHLKTEEELAEEKQILNEMLEVVEQRDSLVALLEEQRLREKEEDKDLEAVMLSKGFNLNWA