Protein
Prefoldin subunit 3
Organism
Drosophila melanogaster
Function
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Required for tubulin stability and spindle and centrosome formation in cooperation with Vhl.
Similarity
Belongs to the prefoldin subunit alpha family.
Sequence
MTGIMDSVEMPKLPENQKTFAGIPEAVFLEEIDTFMSQPENENCEKVLQRLDEQHGKYRFMACNLEARRRKLKSQIPDLERSLEMVNVLRKEDEERETQFLLSDQVFIKTLVPPTKTVYLWLGASVMLEYPLDEAEALLNQNITSAVGNLKSVEHDQDFLRDQITTTEVNMARVYNWGVKKRQAATKTTATTPS