mfd

Transcription-repair-coupling factor

1234 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

132.908 kDa

MTAPGPACSDTPIAGLVELALSAPTFQQLMQRAGGRPDELTLIAPASARLLVASALARQGPLLVVTATGREADDLAAELRGVFGDAVALLPSWETLPHERLSPGVDTVGTRLMALRRLAHPDDAQLGPPLGVVVTSVRSLLQPMTPQLGMMEPLTLTVGDESPFDGVVARLVELAYTRVDMVGRRGEFAVRGGILDIFAPTAEHPVRVEFWGDEITEMRMFSVADQRSIPEIDIHTLVAFACRELLLSEDVRARAAQLAARHPAAESTVTGSASDMLAKLAEGIAVDGMEAVLPVLWSDGHALLTDQLPDGTPVLVCDPEKVRTRAADLIRTGREFLEASWSVAALGTAENQAPVDVEQLGGSGFVELDQVRAAAARTGHPWWTLSQLSDESAIELDVRAAPSARGHQRDIDEIFAMLRAHIATGGYAALVAPGTGTAHRVVERLSESDTPAGMLDPGQAPKPGVVGVLQGPLRDGVIIPGANLVVITETDLTGSRVSAAEGKRLAAKRRNIVDPLALTAGDLVVHDQHGIGRFVEMVERTVGGARREYLVLEYASAKRGGGAKNTDKLYVPMDSLDQLSRYVGGQAPALSRLGGSDWANTKTKARRAVREIAGELVSLYAKRQASPGHAFSPDTPWQAELEDAFGFTETVDQLTAIEEVKADMEKPIPMDRVICGDVGYGKTEIAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFGERMSGFPVTIKGLSRFTDAAESRAVIDGLADGSVDIVIGTHRLLQTGVRWKDLGLVVVDEEQRFGVEHKEHIKSLRTHVDVLTMSATPIPRTLEMSLAGIREMSTILTPPEERYPVLTYVGPHDDKQIAAALRRELLRDGQAFYVHNRVSSIDAAAARVRELVPEARVVVAHGQMPEDLLETTVQRFWNREHDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLRGRVGRSRERGYAYFLYPPQVPLTETAYDRLATIAQNNELGAGMAVALKDLEIRGAGNVLGIEQSGHVAGVGFDLYVRLVGEALETYRDAYRAAADGQTVRTAEEPKDVRIDLPVDAHLPPDYIASDRLRLEGYRRLAAASSDREVAAVVDELTDRYGALPEPARRLAAVARLRLLCRGSGITDVTAASAATVRLSPLTLPDSAQVRLKRMYPGAHYRATTATVQVPIPRAGGLGAPRIRDVELVQMVADLITALAGKPRQHIGITNPSPPGEDGRGRNTTIKERQP

mfd

Transcription-repair-coupling factor

1234 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

132.908 kDa

MTAPGPACSDTPIAGLVELALSAPTFQQLMQRAGGRPDELTLIAPASARLLVASALARQGPLLVVTATGREADDLAAELRGVFGDAVALLPSWETLPHERLSPGVDTVGTRLMALRRLAHPDDAQLGPPLGVVVTSVRSLLQPMTPQLGMMEPLTLTVGDESPFDGVVARLVELAYTRVDMVGRRGEFAVRGGILDIFAPTAEHPVRVEFWGDEITEMRMFSVADQRSIPEIDIHTLVAFACRELLLSEDVRARAAQLAARHPAAESTVTGSASDMLAKLAEGIAVDGMEAVLPVLWSDGHALLTDQLPDGTPVLVCDPEKVRTRAADLIRTGREFLEASWSVAALGTAENQAPVDVEQLGGSGFVELDQVRAAAARTGHPWWTLSQLSDESAIELDVRAAPSARGHQRDIDEIFAMLRAHIATGGYAALVAPGTGTAHRVVERLSESDTPAGMLDPGQAPKPGVVGVLQGPLRDGVIIPGANLVVITETDLTGSRVSAAEGKRLAAKRRNIVDPLALTAGDLVVHDQHGIGRFVEMVERTVGGARREYLVLEYASAKRGGGAKNTDKLYVPMDSLDQLSRYVGGQAPALSRLGGSDWANTKTKARRAVREIAGELVSLYAKRQASPGHAFSPDTPWQAELEDAFGFTETVDQLTAIEEVKADMEKPIPMDRVICGDVGYGKTEIAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFGERMSGFPVTIKGLSRFTDAAESRAVIDGLADGSVDIVIGTHRLLQTGVRWKDLGLVVVDEEQRFGVEHKEHIKSLRTHVDVLTMSATPIPRTLEMSLAGIREMSTILTPPEERYPVLTYVGPHDDKQIAAALRRELLRDGQAFYVHNRVSSIDAAAARVRELVPEARVVVAHGQMPEDLLETTVQRFWNREHDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLRGRVGRSRERGYAYFLYPPQVPLTETAYDRLATIAQNNELGAGMAVALKDLEIRGAGNVLGIEQSGHVAGVGFDLYVRLVGEALETYRDAYRAAADGQTVRTAEEPKDVRIDLPVDAHLPPDYIASDRLRLEGYRRLAAASSDREVAAVVDELTDRYGALPEPARRLAAVARLRLLCRGSGITDVTAASAATVRLSPLTLPDSAQVRLKRMYPGAHYRATTATVQVPIPRAGGLGAPRIRDVELVQMVADLITALAGKPRQHIGITNPSPPGEDGRGRNTTIKERQP

mfd

Transcription-repair-coupling factor

1234 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

132.908 kDa

MTAPGPACSDTPIAGLVELALSAPTFQQLMQRAGGRPDELTLIAPASARLLVASALARQGPLLVVTATGREADDLAAELRGVFGDAVALLPSWETLPHERLSPGVDTVGTRLMALRRLAHPDDAQLGPPLGVVVTSVRSLLQPMTPQLGMMEPLTLTVGDESPFDGVVARLVELAYTRVDMVGRRGEFAVRGGILDIFAPTAEHPVRVEFWGDEITEMRMFSVADQRSIPEIDIHTLVAFACRELLLSEDVRARAAQLAARHPAAESTVTGSASDMLAKLAEGIAVDGMEAVLPVLWSDGHALLTDQLPDGTPVLVCDPEKVRTRAADLIRTGREFLEASWSVAALGTAENQAPVDVEQLGGSGFVELDQVRAAAARTGHPWWTLSQLSDESAIELDVRAAPSARGHQRDIDEIFAMLRAHIATGGYAALVAPGTGTAHRVVERLSESDTPAGMLDPGQAPKPGVVGVLQGPLRDGVIIPGANLVVITETDLTGSRVSAAEGKRLAAKRRNIVDPLALTAGDLVVHDQHGIGRFVEMVERTVGGARREYLVLEYASAKRGGGAKNTDKLYVPMDSLDQLSRYVGGQAPALSRLGGSDWANTKTKARRAVREIAGELVSLYAKRQASPGHAFSPDTPWQAELEDAFGFTETVDQLTAIEEVKADMEKPIPMDRVICGDVGYGKTEIAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFGERMSGFPVTIKGLSRFTDAAESRAVIDGLADGSVDIVIGTHRLLQTGVRWKDLGLVVVDEEQRFGVEHKEHIKSLRTHVDVLTMSATPIPRTLEMSLAGIREMSTILTPPEERYPVLTYVGPHDDKQIAAALRRELLRDGQAFYVHNRVSSIDAAAARVRELVPEARVVVAHGQMPEDLLETTVQRFWNREHDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLRGRVGRSRERGYAYFLYPPQVPLTETAYDRLATIAQNNELGAGMAVALKDLEIRGAGNVLGIEQSGHVAGVGFDLYVRLVGEALETYRDAYRAAADGQTVRTAEEPKDVRIDLPVDAHLPPDYIASDRLRLEGYRRLAAASSDREVAAVVDELTDRYGALPEPARRLAAVARLRLLCRGSGITDVTAASAATVRLSPLTLPDSAQVRLKRMYPGAHYRATTATVQVPIPRAGGLGAPRIRDVELVQMVADLITALAGKPRQHIGITNPSPPGEDGRGRNTTIKERQP

mfd

Transcription-repair-coupling factor

1201 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

132.665 kDa

MRLLITLGPSGSTHGHSLHTDAGRRRGGRPFAQVVDELRAGQRVRTQGLKGAARGHVLARLHGALRAPLVCVAVDEEAADALAADLSFFLGGQGSLLAPRVLRLPADEVLPYDEVSPDAAAVTERLGALFHLGQGTRFPALVLSVRALHRKVLPLAVMRALAARVAVGQDFDRDSLARRLVRMGYQNSPLVEDVGTFSVRGDLLDVFSPLYDKPVRLEFFGDTIESIRAFDPQSQRTVDALKEVDLVPAREVLLTDETRPRAESAARAVADRINLPTIKLREQLDALREGLPGFGMEGLLPGFFEDGLSTVFDFLRDWSPEAPVIYLDDPLGQDRAADTLWEELERSHGAAEARQELICPPLEHFLSREDVNQRMQSFRVLEGGGLSLAQTERPPVHFSFGGTQDLREAILAHHGEEGALSPLVERLERWRELRVACVVACGTLSQADRLKRLLMDRNVMVKVHTEPLEDAVALYEPSIRAHLFTGEVSHGFVDGPGGLAVLADEEIFGARARRRPKRSKKLDAFGSGFGDLKEGDLIVHTDFGIGRYAGLTKMEVNGVPGDFLVLEYAGRDKIYLPVGRMRLIQKFSGGDPTQVQLDKLGTTSWEKTKKRVKEQLLKMAAELLQIAAARKAHPGHAFSAPDRYFAQFEADFEFEETPDQAKAIEDVLADMQKPEPMDRLVCGDVGYGKTEVAMRAAFKAALDRKQVAVLVPTTVLAQQHFLSFKKRFADYPVTVEVISGLKKAPEVREILKRAKEGKVDILIGTHKLLGGEVAFKELGLMIVDEEQRFGVKQKESLKKWRSQIDVLTLTATPIPRTLHMSMSGVRDMSIIATPPQDRRAIRTFVMKYEDTVVKEAIEREVARGGQVFFVHNRVESLPSIETQLRALVPQVSIGVAHGQMGEGQLEKVMLAFTEKKYQVLLCTSIIESGIDISSANTMIVNRADQFGLAQLYQLRGRVGRSKERAYAYLLVPSRRAVTKDAQRRLEVLQNFTELGAGFSIASHDLEIRGAGNLLGDKQSGAIAEIGFDMYAQLLEEAVAEMQGQPPKVQIEPDVTLPMPALIPDDYVSDVHQRLVFYKRFSQASHPDEVTDLRAELVDRYGEAPDEVDHLSELTLLKIDMRDLRLRGLEVGTTRLVVTLGADALLDGPKVAGLVQRSKGVYRLTPDMKLIARAPQGASGQDLISEAKKVLRDLSHCALPQA

mfd

Transcription-repair-coupling factor

1199 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

134.536 kDa

MAEPRAVLKQGNRNRDKDSVGLGNRLRFVSISSALNPMTFSSILRHLQTLPLSKDLREKLQKRGHVQLSGLPRLPKGLIVSSLAQSLEKNLLVITATLEEAGRWTAQLELMGWQTVNFYPTSEASPYDPGRLESEMVWGQMQVLAELIQGHQVKGKAIVATEKALQPHLPPVATLREYCLALRRGQEMDSKSLELTLARLGYERGSTVETEGQWSRRGDIVDIFPVSAELPVRLEWFGDELEKIREFDPASQRSLDDLTGLVLTPTSFDQVIEPALNAQAIDLSAWGEDAETEQLFGKEGLQRFLGLAFTEPACLLDYLPTETVCVLDEPEQCAAHSERWFEAVAQDWSALQLPNLPQLHRNFSALGDRLKTDFQYITLSEIHEANGDSLDISARPIPTMPHQFAKLAEILRGKREIYSGLTLGQYSTWLISAQPSRTVSLLQEHDCAVQFIANPRDYPAIEKSQIQRTAVTLKYSGLAELEGFILPTFRLVLVTDRELFGQHALATPEYVRKRRRATSKQVDINKLSPGDYVVHKSHGIGKFLKLDALANREYLMIQYADGILRVPADSLDSLSRFRHTGTRPPELHKMGGKVWEATKNKVRKAVKKLAVDLLNLYAKRAKQVGYAYPPDSPWQQELEDSFPYQPTPDQLKAVQDVKRDLEGDRPMDRLVCGDVGFGKTEVAVRAIFKAVTSGNKQVALLAPTTVLTQQHYHTLKERFAPYPITIGLLNRFRTASEKKEILAKLKSGELDIVVGTQQVLGTSVKFKDLGLLVIDEEQRFGVNQKEKIKTLKTEVDVLTLTATPIPRTLYMSLSGIREMSLITTPPPSRRPIKTHLSPYNPEVIRTAIRNELDRGGQVFYVVPRIEGIEELGGQLRQMVPSARIAIGHGQMEESELESTMLAFNDGEADILVCTTIIEAGLDIPRVNTIIVEDAQKFGLAQLYQLRGRVGRSGIQAHAWLLYPNQKQLTEKARLRLRALQEFSQLGSGYQLATRDMEIRGVGNLLGAEQSGQMEAIGYEFYMEMLQDAIKEIQGQEIPKVEDTQIDLPLTAFIPSDYIPDLEEKMAAYRRITSIESTDELPKIALDWGDRYGMLPSPVEELFKVVKLKHLAKSLGFSRIKVEGKQNLVLETPMEEPAWKLLAENLPNHLQSRFVYSAKKVVVRGLGVLAPAKQMDNLIDWFGKMQGALPETKMETLVGK

mfd

Transcription-repair-coupling factor

1177 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

133.812 kDa

MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSALANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQRLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEVGYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETLTSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSEGQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLLEEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQMNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYIMEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVHINHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLYKLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQETEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTTILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKDVVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLVPDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKMGLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRDLTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAYIPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVYARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQTKGRSADEWLDTVLGMLKGLKDVKKQTISST

mfd

Transcription-repair-coupling factor

1170 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

134.754 kDa

MKSIITEYINEDKRYQELNEVFGKENVLVTGLSGAAKATIIAEKYLNSEQQLLVVTNNLYQADKLESDLLQFVEDSEIYKYPMQDIMTEEFSTQSPQFMSERVRTLTALAQEERGLFIVPLNGLKKWLTPVDMWKSHQLTLNVGDDIDIDEFLNKLVNMGYRRESVVSHIGEFSLRGGIVDIYPLIGKPVRIEFFDTEVDSIRDFDVESQRSEGNIEHVDITTASDYIITEDVLKHTKHKLKQAYEDTRPKIEKSVRNELKETYESFQLFEAEMFDHQVLRRLVAFMYEQPATIMDYFKEDAIIAVDEYNRIKETETTLVTEIDEFMQNLIESGKGFIDQSFLQYEGFENLLKPFAVTYFTLFTATMPVQLNEIIKFSCKPVQQFYGQYDIMRSEFQRFIQNDYTIVVLAETETKKERIQSMLNEMHIPTFIDTPSRRNEGGSAIITEGSLSEGFELPYMQLVVVTERELFKSKQKKKPKQHKTLTNAEKIKSYQDLKVGDYVVHVHHGVGRYLGVETLEVGGVHKDYIKLQYKGTDQLFVPVDQMDQVQKYVASEDKSPKLNKLGGTEWKKTKAKVQQSVEDMADELIELYKAREMSVGYKFGPDTAEQNDFEIDFPYELTPDQSKSIEEIKQDMEIERPMDRLLCGDVGYGKTEVAVRAAFKAVMEGKQVAFLVPTTILAQQHYETLIERMQDFPIEVQLISRFRTTKEVKETKEGLKSGFVDIVVGTHKLLGKDIQYKDLGLLIVDEEQRFGVRHKERIKSLKNNVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVLEQNTNFIKEALERELSRDGQVFYLYNKVQSIYEKREQLQMLMPDANIGVAHGQMNERDLEETMLSFINHEYDIIVTTTIIETGVDVPNANTLIIEDADRFGLSQLYQLRGRVGRSSRIGYAYFLHPTNKVLSETAEDRLQAIKEFTELGSGFKIAMRDLNIRGAGNLLGKQQHGFIDSVGFDLYSQMLEEAVNEKRGIKAEKQDAPEIEIELNIDAYLPAEYIPNEQSKIEIYKKLRKIESETQLMDVKDELIDRFNDYPIEVERLLEMMEIKVHALHAGVTLIKDVGKQVEVYLSEKGTTDINGETLFKQTQPLGRTMKVGVQEGKMKVTLNKTGNWLDSLKFLTKSLEESMVITDEI

mfd

Transcription-repair-coupling factor

1169 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

134.715 kDa

MKSMIANYISEDNRFQELDEVFGQENILVTGLSPSAKATIIAEKYLKDHKQMLLVTNNLYQADKIETDILQYVDDSEVYKYPVQDIMTEEFSTQSPQLMSERVRTLTALAQGEKGLFIVPLNGFKKWLTPVDLWKDHQMTLKVGQDIDVDAFLNKLVNMGYRRESVVSHIGEFSLRGGIIDIYPLIGTPVRIELFDTEVDSIRDFDVETQRSNDNINQVEITTASDYIITDEVIQHLQNELKKAYEYTRPKIEKSVRNDLKETYESFKLFESTFFDHQLLRRLVSFMYEKPSTLIDYFQKNAIIVVDEFNRIKETEETLTTEVEDFMSNLIESGNGFIGQGFMKYESFDALLEQHAVAYFTLFTSSMQVPLQHIIKFSCKPVQQFYGQYDIMRSEFQRYVHQDYTVVVLVETETKVERIQSMLNEMHIPTVSNIHEDIDGGQVVVTEGSLSEGFELPYMQLVVITERELFKTRQKKQRKRTKTISNAEKIKSYQDLNVGDYIVHVHHGVGRYLGVETLEVGDTHRDYIKLQYKGTDQLFVPVDQMDQVQKYVASEDKSPRLNKLGGTEWKKTKAKVQQSVEDIADELIDLYKEREMSVGYQYGQDTAEQSAFEHDFPYELTPDQSKSIDEIKGDMERARPMDRLLCGDVGYGKTEVAVRAAFKAVMDGKQVAFLVPTTILAQQHYETLLERMQDFPVEIQLVSRFRTAKEIRETKEGLKSGYVDIVVGTHKLLGKDIQYKDLGLLIVDEEQRFGVRHKERIKTLKKNVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVLEQNTNFIKEALERELSRDGQVFYLYNKVQSIYEKREQLQRLMPDANIAVAHGQMTERDLEETMLSFINHEYDILVTTTIIETGVDVPNANTLIIEEADRFGLSQLYQLRGRVGRSSRIGYAYFLHPANKVLNETAEERLQAIKEFTELGSGFKIAMRDLNIRGAGNLLGKQQHGFIDSVGFDLYSQMLEEAVNEKRGIKEESPDAPDIEVELHLDAYLPAEYIQSEQAKIEIYKKLRKVETEEQLFDVKDELIDRFNDYPIEVERLLDIVEIKVHALHAGVELIKDKGKSIQIILSPKATEDINGEELFKQTQPLGRAMKVGVQNNAMNVTLTKSKQWLDSLKFLVRCIEESMAIKDED

mfd

Transcription-repair-coupling factor

1169 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

134.745 kDa

MKSMIANYISEDNRFQELDEVFGQENILVTGLSPSAKATIIAEKYLKDHKQMLLVTNNLYQADKIETDILQYVDDSEVYKYPVQDIMTEEFSTQSPQLMSERVRTLTALAQGEKGLFIVPLNGFKKWLTPVDLWKDHQMTLKVGQDIDVDAFLNKLVNMGYRRESVVSHIGEFSLRGGIIDIYPLIGTPVRIELFDTEVDSIRDFDVETQRSNDNINQVEITTASDYIITDEVIQHLQNELKKAYEYTRPKIEKSVRNDLKETYESFKLFESTFFDHQLLRRLVSFMYEKPSTLIDYFQKNAIIVVDEFNRIKETEETLTTEVEDFMSNLIESGNGFIGQGFMKYESFDALLEQHAVAYFTLFTSSMQVPLQHIIKFSCKPVQQFYGQYDIMRSEFQRYVHQDYTVVVLVETETKVERIQSMLNEMHIPTVSNIHEDIDGGQVVVTEGSLSEGFELPYMQLVVITERELFKTRQKKQRKRTKTISNAEKIKSYQDLNVGDYIVHVHHGVGRYLGVETLEVGDTHRDYIKLQYKGTDQLFVPVDQMDQVQKYVASEDKSPRLNKLGGTEWKKTKAKVQQSVEDIADELIDLYKEREMSVGYQYGQDTAEQSAFEHDFPYELTPDQSKSIDEIKGDMERARPMDRLLCGDVGYGKTEVAVRAAFKAVMDGKQVAFLVPTTILAQQHYETLLERMQDFPVEIQLVSRFRTAKEIRETKEGLKSGYVDIVVGTHKLLGKDIQYKDLGLLIVDEEQRFGVRHKERIKTLKKNVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVLEQNTNFIKEALERELSRDGQVFYLYNKVQSIYEKREQLQRLMPDANIAVAHGQMTERDLEETMLSFINHEYDILVTTTIIETGVDVPNANTLIIEEADRFGLSQLYQLRGRVGRSSRIGYAYFLHPANKVLNETAEERLQTIKEFTELGSGFKIAMRDLNIRGAGNLLGKQQHGFIDSVGFDLYSQMLEEAVNEKRGIKEESPDAPDIEVELHLDAYLPAEYIQSEQAKIEIYKKLRKVETEEQLFDVKDELIDRFNDYPIEVERLLDIVEIKVHALHAGVELIKDKGKSIQIILSPKATEDINGEELFKQTQPLGRAMKVGVQNNAMNVTLTKSKQWLDSLKFLVRCIEESMAIKDED

mfd

Transcription-repair-coupling factor

1169 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

134.926 kDa

MRPIISDYIQNDKRFQELDDVFGHQNILVTGLSPSAKATIIAEKYLKDQKQMLLITNNLYQADKLETDILQYIDHSEVYKYPVQDIMTEEFSTQSPQLMSERVRTLTALAHNKKGLFIVPLNGLKKWLTPFELWKDHQITLRVGEDIDVDEFLNKLVNMGYRRESVVSHIGEFSLRGGIIDIYPLIGQPVRIELFDTEVDSIRDFDVETQRSNDNIEEVSITTASDYVITDDVIQHLQSELKTAYEATRPKIDKSVRNDLKETYESFKLFETTFFDHQLLRRLVAFMYEQPSTLIDYFAKDAIIVADEYNRIKETEKTLTTEVDDFIQNLIESGNGFIGQSFMQYDGFESLLKDYPVTYFTLFTSTMPVQLQHIIKFSCKPVQQFYGQYDIMRSEFQRYVHNDYHIVVLVETETKVERIQSMLNEMHIPTVTNVQNDIKSGQVVVTEGSLSEGFELPYMQLVVITERELFKTKQKKQRKRTKTLSNAEKIKSYQDLNVGDYVVHVHHGVGRYLGVETLEVGDVHRDYIKLQYKGTDQLFVPVDQMDQVQKYVASEDKSPKLNKLGGSEWKKTKAKVQQSVEDIADELIALYKEREMSVGYQYGEDTAEQSAFEMDFPYELTPDQAKSIDEIKGDMERERPMDRLLCGDVGYGKTEVAVRAAFKAVMEGKQVAFLVPTTILAQQHYETLIERMQDFPVQIELISRFRSTKEVKETKEGLKSGYVDIVVGTHKLLGKDIHYKDLGLLIVDEEQRFGVRHKERIKTMKTNVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVLEQNSNFIKEALERELSRDGQVFYLYNRVQSIYEKREQLQMLMPDANIAVAHGQMTERDLEETMLSFINGEFDILVTTTIIETGVDVPNANTLIIEEADRFGLSQLYQLRGRVGRSSRIGYAYFLHSANKVLTETAEERLQAIKEFTELGSGFKIAMRDLNIRGAGNLLGKQQHGFIDSVGFDLYSQMLEEAVNEKRGIKEEEPDAPEVEMELNLDAYLPAEYIQNEQAKIEIYKKLRKVETEEQLFDIKDELIDRFNDYPVEVERLLEMVEIKIHALHAGVTLIKDKGKQIEVSLSTKATEQMNGEELFKQTQPLGRAMKLGVKENRMHVTLTKSKQWLDNLKFLVRCLEGSMVIEDEN

mfd

Transcription-repair-coupling factor

1168 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

134.219 kDa

MTILTTLIKEDNHFQDLNQVFGQANTLVTGLSPSAKVTMIAEKYAQSNQQLLLITNNLYQADKLETDLLQFIDAEELYKYPVQDIMTEEFSTQSPQLMSERIRTLTALAQGKKGLFIVPLNGLKKWLTPVEMWQNHQMTLRVGEDIDVDQFLNKLVNMGYKRESVVSHIGEFSLRGGIIDIFPLIGEPIRIELFDTEIDSIRDFDVETQRSKDNVEEVDITTASDYIITEEVISHLKEELKTAYENTRPKIDKSVRNDLKETYESFKLFESTYFDHQILRRLVAFMYETPSTIIEYFQKDAIIAVDEFNRIKETEESLTVESDSFISNIIESGNGFIGQSFIKYDDFETLIEGYPVTYFSLFATTMPIKLNHIIKFSCKPVQQFYGQYDIMRSEFQRYVNQNYHIVVLVETETKVERMQAMLSEMHIPSITKLHRSMSSGQAVIIEGSLSEGFELPDMGLVVITERELFKSKQKKQRKRTKAISNAEKIKSYQDLNVGDYIVHVHHGVGRYLGVETLEVGQTHRDYIKLQYKGTDQLFVPVDQMDQVQKYVASEDKTPKLNKLGGSEWKKTKAKVQQSVEDIAEELIDLYKEREMAEGYQYGEDTAEQTTFELDFPYELTPDQAKSIDEIKDDMQKSRPMDRLLCGDVGYGKTEVAVRAAFKAVMEGKQVAFLVPTTILAQQHYETLIERMQDFPVEIQLMSRFRTPKEIKQTKEGLKTGFVDIVVGTHKLLSKDIQYKDLGLLIVDEEQRFGVRHKERIKTLKHNVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVLEQNMSFIKEALERELSRDGQVFYLYNKVQSIYEKREQLQMLMPDANIAVAHGQMTERDLEETMLSFINNEYDILVTTTIIETGVDVPNANTLIIEDADRFGLSQLYQLRGRVGRSSRIGYAYFLHPANKVLTETAEDRLQAIKEFTELGSGFKIAMRDLNIRGAGNLLGKQQHGFIDTVGFDLYSQMLEEAVNEKRGIKEPESEVPEVEVDLNLDAYLPTEYIANEQAKIEIYKKLRKTETFDQIIDIKDELIDRFNDYPVEVARLLDIVEIKVHALHSGITLIKDKGKIIDIHLSVKATENIDGEVLFKATQPLGRTMKVGVQNNAMTITLTKQNQWLDSLKFLVKCIEESMRISDEA

mfd

Transcription-repair-coupling factor

1168 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

134.219 kDa

MTILTTLIKEDNHFQDLNQVFGQANTLVTGLSPSAKVTMIAEKYAQSNQQLLLITNNLYQADKLETDLLQFIDAEELYKYPVQDIMTEEFSTQSPQLMSERIRTLTALAQGKKGLFIVPLNGLKKWLTPVEMWQNHQMTLRVGEDIDVDQFLNKLVNMGYKRESVVSHIGEFSLRGGIIDIFPLIGEPIRIELFDTEIDSIRDFDVETQRSKDNVEEVDITTASDYIITEEVISHLKEELKTAYENTRPKIDKSVRNDLKETYESFKLFESTYFDHQILRRLVAFMYETPSTIIEYFQKDAIIAVDEFNRIKETEESLTVESDSFISNIIESGNGFIGQSFIKYDDFETLIEGYPVTYFSLFATTMPIKLNHIIKFSCKPVQQFYGQYDIMRSEFQRYVNQNYHIVVLVETETKVERMQAMLSEMHIPSITKLHRSMSSGQAVIIEGSLSEGFELPDMGLVVITERELFKSKQKKQRKRTKAISNAEKIKSYQDLNVGDYIVHVHHGVGRYLGVETLEVGQTHRDYIKLQYKGTDQLFVPVDQMDQVQKYVASEDKTPKLNKLGGSEWKKTKAKVQQSVEDIAEELIDLYKEREMAEGYQYGEDTAEQTTFELDFPYELTPDQAKSIDEIKDDMQKSRPMDRLLCGDVGYGKTEVAVRAAFKAVMEGKQVAFLVPTTILAQQHYETLIERMQDFPVEIQLMSRFRTPKEIKQTKEGLKTGFVDIVVGTHKLLSKDIQYKDLGLLIVDEEQRFGVRHKERIKTLKHNVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVLEQNMSFIKEALERELSRDGQVFYLYNKVQSIYEKREQLQMLMPDANIAVAHGQMTERDLEETMLSFINNEYDILVTTTIIETGVDVPNANTLIIEDADRFGLSQLYQLRGRVGRSSRIGYAYFLHPANKVLTETAEDRLQAIKEFTELGSGFKIAMRDLNIRGAGNLLGKQQHGFIDTVGFDLYSQMLEEAVNEKRGIKEPESEVPEVEVDLNLDAYLPTEYIANEQAKIEIYKKLRKTETFDQIIDIKDELIDRFNDYPVEVARLLDIVEIKVHALHSGITLIKDKGKIIDIHLSVKATENIDGEVLFKATQPLGRTMKVGVQNNAMTITLTKQNQWLDSLKFLVKCIEESMRISDEA

mfd

Transcription-repair-coupling factor

1168 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

134.278 kDa

MTILTTLIKEDNHFQDLNQVFGQANTLVTGLSPSAKVTMIAEKYAQSNQQLLLITNNLYQADKLETDLLQFIDAEELYKYPVQDIMTEEFSTQSPQLMSERIRTLTALAQGKKGLFIVPLNGLKKWLTSVEMWQNHQMTLRVGEDIDVDQFLNKLVNMGYKRESVVSHIGEFSLRGGIIDIFPLIGEPIRIELFDTEIDSIRDFDVETQRSKDNIEEVDITTASDYIITEEVIRHLKEELKTAYENTRPKIDKSVRNDLKETYESFKLFESTYFDHQILRRLVAFMYETPSTIIDYFQKDAIIAVDEFNRIKETEESLTVESDSFISNIIESGNGFIGQSFIKYDDFETLIEGYPVTYFSLFATTMPIKLNHIIKFSCKPVQQFYGQYDIMRSEFQRYVNQNYHIVVLVETETKVERMQAMLSEMHIPSITKLHRSMSSGQAVIIEGSLSEGFELPDMGLVVITERELFKSKQKKQRKRTKAISNAEKIKSYQDLNVGDYIVHVHHGVGRYLGVETLEVGQTHRDYIKLQYKGTDQLFVPVDQMDQVQKYVASEDKTPKLNKLGGSEWKKTKAKVQQSVEDIAEELIDLYKEREMAEGYQYGEDTAEQTTFELDFPYELTPDQAKSIDEIKDDMQKSRPMDRLLCGDVGYGKTEVAVRAAFKAVMEGKQVAFLVPTTILAQQHYETLIERMQDFPVEIQLMSRFRTPKEIKQTKEGLKTGFVDIVVGTHKLLSKDIQYKDLGLLIVDEEQRFGVRHKERIKTLKHNVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVLEQNMSFIKEALERELSRDGQVFYLYNKVQSIYEKREQLQMLMPDANIAVAHGQMTERDLEETMLSFINNEYDILVTTTIIETGVDVPNANTLIIEDADRFGLSQLYQLRGRVGRSSRIGYAYFLHPANKVLTETAEDRLQAIKEFTELGSGFKIAMRDLNIRGAGNLLGKQQHGFIDTVGFDLYSQMLEEAVNEKRGIKEPESEVPEVEVDLNLDAYLPTEYIANEQAKIEIYKKLRKTETFDQIIDIKDELIDRFNDYPVEVARLLDIVEIKVHALHSGITLIKDKGKIIDIHLSVKATENIDGEVLFKATQPLGRTMKVGVQNNAMTITLTKQNQWLDSLKFLVKCIEESMRISDEA

mfd

Transcription-repair-coupling factor

1168 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

134.229 kDa

MTILTTLIKEDNHFQDLNQVFGQANTLVTGLSPSAKVTMIAEKYAQSNQQLLLITNNLYQADKLETDLLQFIDAEELYKYPVQDIMTEEFSTQSPQLMSERIRTLTALAQGKKGLFIVPLNGLKKWLTPVEMWQNHQMTLRVGEDIDVDQFLNKLVNMGYKRESVVSHIGEFSLRGGIIDIFPLIGEPIRIELFDTEIDSIRDFDVETQRSKDNVEEVDITTASDYIITEEVISHLKEELKTAYENTRPKIDKSVRNDLKETYESFKLFESTYFDHQILRRLVAFMYETPSTIIEYFQKDAIIAVDEFNRIKETEESLTVEPDSFISNIIESGNGFIGQSFIKYDDFETLIEGYPVTYFSLFATTMPIKLNHIIKFSCKPVQQFYGQYDIMRSEFQRYVNQNYHIVVLVETETKVERMQAMLSEMHIPSITKLHRSMSSGQAVIIEGSLSEGFELPDMGLVVITERELFKSKQKKQRKRTKAISNAEKIKSYQDLNVGDYIVHVHHGVGRYLGVETLEVGQTHRDYIKLQYKGTDQLFVPVDQMDQVQKYVASEDKTPKLNKLGGSEWKKTKAKVQQSVEDIAEELIDLYKEREMAEGYQYGEDTAEQTTFELDFPYELTPDQAKSIDEIKDDMQKSRPMDRLLCGDVGYGKTEVAVRAAFKAVMEGKQVAFLVPTTILAQQHYETLIERMQDFPVEIQLMSRFRTPKEIKQTKEGLKTGFVDIVVGTHKLLSKDIQYKDLGLLIVDEEQRFGVRHKERIKTLKHNVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVLEQNMSFIKEALERELSRDGQVFYLYNKVQSIYEKREQLQMLMPDANIAVAHGQMTERDLEETMLSFINNEYDILVTTTIIETGVDVPNANTLIIEDADRFGLSQLYQLRGRVGRSSRIGYAYFLHPANKVLTETAEDRLQAIKEFTELGSGFKIAMRDLNIRGAGNLLGKQQHGFIDTVGFDLYSQMLEEAVNEKRGIKEPESEVPEVEVDLNLDAYLPTEYIANEQAKIEIYKKLRKTETFDQIIDIKDELIDRFNDYPVEVARLLDIVEIKVHALHSGITLIKDKGKIIDIHLSVKATENIDGEVLFKATQPLGRTMKVGVQNNAMTITLTKQNQWLDSLKFLVKCIEESMRISDEA

mfd

Transcription-repair-coupling factor

1168 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

134.302 kDa

MTILTTLIKEDNHFQDLNQVFGQANTLVTGLSPSAKVTMIAEKYAQSNQQLLLITNNLYQADKLETDLLQFIDAEELYKYPVQDIMTEEFSTQSPQLMSERIRTLTALAQGKKGLFIVPLNGLKKWLTPVEMWQNHQMTLRVGEDIDVDQFLNKLVNMGYKRESVVSHIGEFSLRGGIIDIFPLIGEPIRIELFDTEIDSIRDFDVETQRSKDNIEEVDITTASDYIITEEVIRHLKEELKTAYENTRPKIDKSVRNDLKETYESFKLFESTYFDHQILRRLVAFMYETPSTIIEYFQKDAIIAVDEFNRIKETEESLTVESDSFISNIIESGNGFIGQSFIKYDDFETLIEGYPVTYFSLFATTMPIKLNHIIKFSCKPVQQFYGQYDIMRSEFQRYVNQNYHIVVLVETETKVERMQAMLSEMHIPSITKLHRSMSSGQAVIIEGSLSEGFELPDMGLVVITERELFKSKQKKQRKRTKAISNAEKIKSYQDLNVGDYIVHVHHGVGRYLGVETLEVGQTHRDYIKLQYKGTDQLFVPVDQMDQVQKYVASEDKTPKLNKLGGSEWKKTKAKVQQSVEDIAEELIDLYKEREMAEGYQYGEDTAEQTTFELDFPYELTPDQAKSIDEIKDDMQKSRPMDRLLCGDVGYGKTEVAVRAAFKAVMEGKQVAFLVPTTILAQQHYETLIERMQDFPVEIQLMSRFRTPKEIKQTKEGLKTGFVDIVVGTHKLLSKDIQYKDLGLLIVDEEQRFGVRHKERIKTLKHNVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVLEQNMSFIKEALERELSRDGQVFYLYNKVQSIYEKREQLQMLMPDANIAVAHGQMTERDLEETMLSFINNEYDILVTTTIIETGVDVPNANTLIIEDADRFGLSQLYQLRGRVGRSSRIGYAYFLHPANKVLTETAEDRLQAIKEFTELGSGFKIAMRDLNIRGAGNLLGKQQHGFIDTVGFDLYSQMLEEAVNEKRGIKEPESEVPEVEVDLNLDAYLPTEYIANEQAKIEIYKKLRKTETFDQIIDIKDELIDRFNDYPVEVARLLDIVEIKVHALHSGITLIKDKGKIIDIHLSVKATENIDGEVLFKATQPLGRTMKVGVQNNAMTITLTKQNQWLDSLKFLVKCIEESMRISDEA

mfd

Transcription-repair-coupling factor

1168 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

134.302 kDa

MTILTTLIKEDNHFQDLNQVFGQANTLVTGLSPSAKVTMIAEKYAQSNQQLLLITNNLYQADKLETDLLQFIDAEELYKYPVQDIMTEEFSTQSPQLMSERIRTLTALAQGKKGLFIVPLNGLKKWLTPVEMWQNHQMTLRVGEDIDVDQFLNKLVNMGYKRESVVSHIGEFSLRGGIIDIFPLIGEPIRIELFDTEIDSIRDFDVETQRSKDNIEEVDITTASDYIITEEVIRHLKEELKTAYENTRPKIDKSVRNDLKETYESFKLFESTYFDHQILRRLVAFMYETPSTIIEYFQKDAIIAVDEFNRIKETEESLTVESDSFISNIIESGNGFIGQSFIKYDDFETLIEGYPVTYFSLFATTMPIKLNHIIKFSCKPVQQFYGQYDIMRSEFQRYVNQNYHIVVLVETETKVERMQAMLSEMHIPSITKLHRSMSSGQAVIIEGSLSEGFELPDMGLVVITERELFKSKQKKQRKRTKAISNAEKIKSYQDLNVGDYIVHVHHGVGRYLGVETLEVGQTHRDYIKLQYKGTDQLFVPVDQMDQVQKYVASEDKTPKLNKLGGSEWKKTKAKVQQSVEDIAEELIDLYKEREMAEGYQYGEDTAEQTTFELDFPYELTPDQAKSIDEIKDDMQKSRPMDRLLCGDVGYGKTEVAVRAAFKAVMEGKQVAFLVPTTILAQQHYETLIERMQDFPVEIQLMSRFRTPKEIKQTKEGLKTGFVDIVVGTHKLLSKDIQYKDLGLLIVDEEQRFGVRHKERIKTLKHNVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVLEQNMSFIKEALERELSRDGQVFYLYNKVQSIYEKREQLQMLMPDANIAVAHGQMTERDLEETMLSFINNEYDILVTTTIIETGVDVPNANTLIIEDADRFGLSQLYQLRGRVGRSSRIGYAYFLHPANKVLTETAEDRLQAIKEFTELGSGFKIAMRDLNIRGAGNLLGKQQHGFIDTVGFDLYSQMLEEAVNEKRGIKEPESEVPEVEVDLNLDAYLPTEYIANEQAKIEIYKKLRKTETFDQIIDIKDELIDRFNDYPVEVARLLDIVEIKVHALHSGITLIKDKGKIIDIHLSVKATENIDGEVLFKATQPLGRTMKVGVQNNAMTITLTKQNQWLDSLKFLVKCIEESMRISDEA

mfd

Transcription-repair-coupling factor

1168 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

134.231 kDa

MTILTTLIKEDNHFQDLNQVFGQANTLVTGLSPSAKVTMIAEKYAQSNQQLLLITNNLYQADKLETDLLQFVDVEELYKYPVQDIMTEEFSTQSPQLMSERIRTLTALAQGKKGLFIVPLNGLKKWLTPVEMWQNHQMTLRVGEDIDVDQFLNKLVNMGYKRESVVSHIGEFSLRGGIIDIFPLIGEPIRIELFDTEIDSIRDFDVETQRSKDNIEEVDITTASDYIITEEVISHLKEELKTAYENTRPKIDKSVRNDLKETYESFKLFESTYFDHQILRRLVAFMYETPSTIIDYFQKDAIIAVDEFNRIKETEESLTVESDSFISNVIESGNGFIGQSFIKYDDFETLIEGYPVTYFSLFATTMPIKLNHIIKFSCKPVQQFYGQYDIMRSEFQRYVNQNYHIVVLVETETKVERMQAMLSEMHIPSITKLHRSMSSGQAVIIEGSLSEGFELPDMGLVVITERELFKSKQKKQRKRTKAISNAEKIKSYQDLNVGDYIVHVHHGVGRYLGVETLEVGQIHRDYIKLQYKGTDQLFVPVDQMDQVQKYVASEDKTPKLNKLGGSEWKKTKAKVQQSVEDIAEELIDLYKEREMAEGYQYGEDTAEQTTFELDFPYELTPDQAKSIDEIKDDMQKSRPMDRLLCGDVGYGKTEVAVRAAFKAVMEGKQVAFLVPTTILAQQHYETLIERMQDFPVEIQLMSRFRTPKEIKQTKEGLKTGFVDIVVGTHKLLSKDIQYKDLGLLIVDEEQRFGVRHKERIKTLKHNVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVLEQNMSFIKEALERELSRDGQVFYLYNKVQSIYEKREQLQMLMPDANIAVAHGQMTERDLEETMLSFINNEYDILVTTTIIETGVDVPNANTLIIEDADRFGLSQLYQLRGRVGRSSRIGYAYFLHPANKVLTETAEDRLQAIKEFTELGSGFKIAMRDLNIRGAGNLLGKQQHGFIDTVGFDLYSQMLEEAVNEKRGIKEPESEVPEVEVDLNLDAYLPTEYIANEQAKIEIYKKLRKTETFDQIIDIKDELIDRFNDYPVEVARLLDIVEIKVHALHSGITLIKDKGKIIDIHLSVKATENIDGEVLFKATQPLGRTMKVGVQNNAMTITLTKQNQWLDSLKFLVKCIEESMRISDEA

mfd

Transcription-repair-coupling factor

1168 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

134.218 kDa

MTILTTLIKEDNHFQDLNQVFGQANTLVTGLSPSAKVTMIAEKYAQSNQQLLLITNNLYQADKLETDLLQFIDAEELYKYPVQDIMTEEFSTQSPQLMSERIRTLTALAQGKKGLFIVPLNGLKKWLTPVEMWQNHQMTLRVGEDIDVDQFLNKLVNMGYKRESVVSHIGEFSLRGGIIDIFPLIGEPIRIELFDTKIDSIRDFDVETQRSKDNVEEVDITTASDYIITEEVISHLKEELKTAYENTRPKIDKSVRNDLKETYESFKLFESTYFDHQILRRLVAFMYETPSTIIEYFQKDAIIAVDEFNRIKETEESLTVESDSFISNIIESGNGFIGQSFIKYDDFETLIEGYPVTYFSLFATTMPIKLNHIIKFSCKPVQQFYGQYDIMRSEFQRYVNQNYHIVVLVETETKVERMQAMLSEMHIPSITKLHRSMSSGQAVIIEGSLSEGFELPDMGLVVITERELFKSKQKKQRKRTKAISNAEKIKSYQDLNVGDYIVHVHHGVGRYLGVETLEVGQTHRDYIKLQYKGTDQLFVPVDQMDQVQKYVASEDKTPKLNKLGGSEWKKTKAKVQQSVEDIAEELIDLYKEREMAEGYQYGEDTAEQTTFELDFPYELTPDQAKSIDEIKDDMQKSRPMDRLLCGDVGYGKTEVAVRAAFKAVMEGKQVAFLVPTTILAQQHYETLIERMQDFPVEIQLMSRFRTPKEIKQTKEGLKTGFVDIVVGTHKLLSKDIQYKDLGLLIVDEEQRFGVRHKERIKTLKHNVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVLEQNMSFIKEALERELSRDGQVFYLYNKVQSIYEKREQLQMLMPDANIAVAHGQMTERDLEETMLSFINNEYDILVTTTIIETGVDVPNANTLIIEDADRFGLSQLYQLRGRVGRSSRIGYAYFLHPANKVLTETAEDRLQAIKEFTELGSGFKIAMRDLNIRGAGNLLGKQQHGFIDTVGFDLYSQMLEEAVNEKRGIKEPESEVPEVEVDLNLDAYLPTEYIANEQAKIEIYKKLRKTETFDQIIDIKDELIDRFNDYPVEVARLLDIVEIKVHALHSGITLIKDKGKIIDIHLSVKATENIDGEVLFKATQPLGRTMKVGVQNNAMTITLTKQNQWLDSLKFLVKCIEESMRISDEA

mfd

Transcription-repair-coupling factor

1168 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

134.218 kDa

MTILTTLIKEDNHFQDLNQVFGQANTLVTGLSPSAKVTMIAEKYAQSNQQLLLITNNLYQADKLETDLLQFIDAEELYKYPVQDIMTEEFSTQSPQLMSERIRTLTALAQGKKGLFIVPLNGLKKWLTPVEMWQNHQMTLRVGEDIDVDQFLNKLVNMGYKRESVVSHIGEFSLRGGIIDIFPLIGEPIRIELFDTKIDSIRDFDVETQRSKDNVEEVDITTASDYIITEEVISHLKEELKTAYENTRPKIDKSVRNDLKETYESFKLFESTYFDHQILRRLVAFMYETPSTIIEYFQKDAIIAVDEFNRIKETEESLTVESDSFISNIIESGNGFIGQSFIKYDDFETLIEGYPVTYFSLFATTMPIKLNHIIKFSCKPVQQFYGQYDIMRSEFQRYVNQNYHIVVLVETETKVERMQAMLSEMHIPSITKLHRSMSSGQAVIIEGSLSEGFELPDMGLVVITERELFKSKQKKQRKRTKAISNAEKIKSYQDLNVGDYIVHVHHGVGRYLGVETLEVGQTHRDYIKLQYKGTDQLFVPVDQMDQVQKYVASEDKTPKLNKLGGSEWKKTKAKVQQSVEDIAEELIDLYKEREMAEGYQYGEDTAEQTTFELDFPYELTPDQAKSIDEIKDDMQKSRPMDRLLCGDVGYGKTEVAVRAAFKAVMEGKQVAFLVPTTILAQQHYETLIERMQDFPVEIQLMSRFRTPKEIKQTKEGLKTGFVDIVVGTHKLLSKDIQYKDLGLLIVDEEQRFGVRHKERIKTLKHNVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVLEQNMSFIKEALERELSRDGQVFYLYNKVQSIYEKREQLQMLMPDANIAVAHGQMTERDLEETMLSFINNEYDILVTTTIIETGVDVPNANTLIIEDADRFGLSQLYQLRGRVGRSSRIGYAYFLHPANKVLTETAEDRLQAIKEFTELGSGFKIAMRDLNIRGAGNLLGKQQHGFIDTVGFDLYSQMLEEAVNEKRGIKEPESEVPEVEVDLNLDAYLPTEYIANEQAKIEIYKKLRKTETFDQIIDIKDELIDRFNDYPVEVARLLDIVEIKVHALHSGITLIKDKGKIIDIHLSVKATENIDGEVLFKATQPLGRTMKVGVQNNAMTITLTKQNQWLDSLKFLVKCIEESMRISDEA

mfd

Transcription-repair-coupling factor

1148 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site. Can also dissociate RNAP that is blocked by low concentration of nucleoside triphosphates or by physical obstruction, such as bound proteins. In addition, can rescue arrested complexes by promoting forward translocation. Has ATPase activity, which is required for removal of stalled RNAP, but seems to lack helicase activity. May act through a translocase activity that rewinds upstream DNA, leading either to translocation or to release of RNAP when the enzyme active site cannot continue elongation.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

129.983 kDa

MPEQYRYTLPVKAGEQRLLGELTGAACATLVAEIAERHAGPVVLIAPDMQNALRLHDEISQFTDQMVMNLADWETLPYDSFSPHQDIISSRLSTLYQLPTMQRGVLIVPVNTLMQRVCPHSFLHGHALVMKKGQRLSRDALRTQLDSAGYRHVDQVMEHGEYATRGALLDLFPMGSELPYRLDFFDDEIDSLRVFDVDSQRTLEEVEAINLLPAHEFPTDKAAIELFRSQWRDTFEVKRDPEHIYQQVSKGTLPAGIEYWQPLFFSEPLPPLFSYFPANTLLVNTGDLETSAERFQADTLARFENRGVDPMRPLLPPQSLWLRVDELFSELKNWPRVQLKTEHLPTKAANANLGFQKLPDLAVQAQQKAPLDALRKFLETFDGPVVFSVESEGRREALGELLARIKIAPQRIMRLDEASDRGRYLMIGAAEHGFVDTVRNLALICESDLLGERVARRRQDSRRTINPDTLIRNLAELHIGQPVVHLEHGVGRYAGMTTLEAGGITGEYLMLTYANDAKLYVPVSSLHLISRYAGGAEENAPLHKLGGDAWSRARQKAAEKVRDVAAELLDIYAQRAAKEGFAFKHDREQYQLFCDSFPFETTPDQAQAINAVLSDMCQPLAMDRLVCGDVGFGKTEVAMRAAFLAVDNHKQVAVLVPTTLLAQQHYDNFRDRFANWPVRIEMISRFRSAKEQTQILAEVAEGKIDILIGTHKLLQSDVKFKDLGLLIVDEEHRFGVRHKERIKAMRANVDILTLTATPIPRTLNMAMSGMRDLSIIATPPARRLAVKTFVREYDSMVVREAILREILRGGQVYYLYNDVENIQKAAERLAELVPEARIAIGHGQMRERELERVMNDFHHQRFNVLVCTTIIETGIDIPTANTIIIERADHFGLAQLHQLRGRVGRSHHQAYAWLLTPHPKAMTTDAQKRLEAIASLEDLGAGFALATHDLEIRGAGELLGEEQSGSMETIGFSLYMELLENAVDALKAGREPSLEDLTSQQTEVELRMPSLLPDDFIPDVNTRLSFYKRIASAKTENELEEIKVELIDRFGLLPDPARTLLDIARLRQQAQKLGIRKLEGNEKGGVIEFAEKNHVNPAWLIGLLQKQPQHYRLDGPTRLKFIQDLSERKTRIEWVRQFMRELEENAIA

mfd

Transcription-repair-coupling factor

1146 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

130.13 kDa

MKTAFFQPDIPTQPNDHKILGNVLPGADALAISEISEQNQNLTVVVTPDTRSAVRLSRVLSELSSQDVCLFPDWETLPYDTFSPHQEIISSRLSALFHLQNAKKGIFLLPISTLMQRLCPPQYLQHNVLLIKKGDRLVIDKMRLQLEAAGYRAVEQVLEHGEYAVRGALLDLFPMGSAVPFRLDFFDDEIDSIRTFDVDTQRTLDEISSINLLPAHEFPTDDKGIEFFRAQFRETFGEIRRDPEHIYQQISKGTLISGIEYWQPLFFAEMATLFDYLPEQTLFVDMENNQTQGERFYQDAKQRYEQRKVDPMRPLLSPEKLWLNVDEVNRRLKSYPRITFKAEKVRSSVRQKNLPVAALPEVTIQSQQKEPLGQLRQFIEHFKGNVLFSVETEGRRETLLDLLSPLKLKPKQIQSLEQIENEKFSLLVSSLEQGFIIEQSLPVAIIGEANLLGKRIQQRSRDKRKTINPDTLVRNLAELKIGQPVVHLDHGVGRYGGLVTLDTGGIKAEYLLLNYANESKLYVPVTSLHLISRYVGGSDESAPLHKLGNEAWAKSRQKAAEKIRDVAAELLDVYAQREAKKGFAFKYDREEFQQFSATFPFEETYDQEMAINAVISDMCQPKAMDRLVCGDVGFGKTEVAMRAAFLAVMNHKQVAVLVPTTLLAQQHYENFKDRFANLPVNVEVLSRFKTAKEQKQILENLAEGKVDILIGTHKLIQSDVKFNDLGLLIIDEEHRFGVGQKEKIKQLRANIDILTLTATPIPRTLNMAMNGIRDLSIISTPPARRLSIKTFVRQNDDLVVREAILREILRGGQVYYLHNDVASIENTAEKLTALVPEARVIVGHGQMRERELERVMSDFYHQRYNVLVCSTIIETGIDVPTANTIIIERADHFGLAQLHQLRGRVGRSHHQAYAYLLTPPPKMMTKDAERRLDALENLDNLGAGFILATHDLEIRGAGELLGNEQSGQIESIGFSLYMELLDAAVKALKEGREPSLEELTQQQADIELRVPALLPDDYLGDVNMRLSFYKRIAAAESKAELDELKVELIDRFGLLPDATKNLLQITELRLLVEPLNVVRIDAGTQGGFIEFSAKAQVNPDKFIQLIQKEPIVYRFDGPFKFKFMKDLSDNKVRLEFVVDLLRTIAA

mfd

Transcription-repair-coupling factor

1142 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

129.663 kDa

MLQQKFPATAKSFFATHNFTKNLKQDFILSSSNEDEALQLYKQALFFSSNENIYYFPSYDTIPYDHTSPNANILSRRAEILTKLTTNNSNGKLLITYAANLLNKLPPKDFFSKYFLKLSPKMKFTTDELAMFLVENSFTRNASSIDVGEFAVRGEIIDIILPGPKAYRINFSWDYIESIKEFDIDTQISTKSCSELVISPANEIVLNSETNGNFKNNYLRNFGVNHTDNPLYEAVISGRKFAGYEQLLPLFYNSCSSLVDYLNDPIFIFDNLSKQAILEFEHSYNDFYSARSEVNKLKFNSFYPTLSPTDLYFTASEITELLEQKNNIFISYENSEQATLIENISSASFIEKKTVFDKLFEIIKAHSSKKIVIGAASLSGLERIKSITQNYEYKYNEINKLDEAKASVINVGIIPLNQSFYTKEYLFITASELLEEKSSSTNTNKKLKNILLELDNLAEGEFVVHKDHGIGQFLKLEALEIKGKLHDFLKILYAGNDKLYIPVENIEVIKKYGNDNAELDKLGSSSWQRSKAKLKNRIKEIALHLIQIAAKRKLNSSASVEFDLEEYDKFCANFPFSETEDQLTAINDIKEDLRNGMLMDRLICGDVGFGKTEVAMRAVFMVAKSLNEHLPQVAVVVPTTILCSQHFSRFIERFKGFGLNIKQLSSVISAKEAKIIRSELESGKINIIIGTHSLLHKNTKFFNLKLLIIDEEQHFGVGQKEFLKSLKSSSHVLAMSATPIPRTLQMSMTGLKELSIIATPPLNRLEVRTMVMPFDPVIIRDALLREHFRGGRSFYVVPRIKDIEDIEKQLKQIVPELSYKIAHGKMTPSKIDEVMSEFYAGKFDILVSTTIIESGIDIAEANTMVIHKADMLGLSQLYQLRGRIGRGKVRGYAYLTVASHKKMTSHSLRRLEIIQNSCALGSGFTIASHDMDLRGFGNLIGEEQSGQIKEVGTELYQEMLEEQIAIFKDEPIVSEQLFIPTINLGLSVFIPDNYISDSALKLGLYRRIGNLSNEIEVEKFKDEMIDRFGSLPIEFNNLLDIVKIKLLCFKLNIENLDSGDNGFVIKFYKNADMTDKILKFVSTYSNQAKIKPDNKLVYIKKLVDKNIIVEVNQLLWKLGGCRLDVIPNTSLRGAKRRGNLIK

mfd

Transcription-repair-coupling factor

1125 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

130.73 kDa

MNIDEELTTILKNNSNLKKMKEFLEQNIFFSLTGYEGFFKAFLIKKIKEYSKTGKIILIVKDEHTLDKIKNDLQVITNQIFELNYFSPLVYKGIGSKSTIFNERIKFLFNFYKKNPGIYITVLKSLLSKIPDKNTLLKNIYKIEKNTNINTADIEKTLITLGYEKTLRVTIPGEFTVKGEIIDIYPFGEQNPIRIALNFDKIEEIKKFNPLTQLKHDNEILEFQILPKKEIIWDDKTINTLKTKIKSVEYKKILEELDFKKETKTEEMFYPLVANTYLGDEIEKHTPIVNFEINNFEKEIEKIHQEYEKLYKEAEEAGKNIIDPKRILLNYKTFNLKSDVLFSKIKSLKSKETIEFKIESERNFFSNIALTKEEFENWLKNGFKIIIAAESESQKEKLKYIFKELPKVSIEVLKISSSLIIEKEKIAIILESNIFNTGQKINKAFESSKTKAIDSFVEIEKNSHVVHINHGIGIFRQIKRIKTSSLEKDYIEIEYAEGEKLFIPIEQTNLIQKYIGSDPKNIKLDKISSKTWIKNKANAKKRIEEIADKLIELYSKRESIKGIKYPEDNELQLLFESEFPYDETPDQIRAIKEIKEDMMSFKVMDRLLCGDVGFGKTEVAMRAAFKAVMGNKQVIVLSPTTILAEQHFNTFKKRFKNFPIKIEVLSRFIKNNAESRILKELKSGKIDIIIGTHKILSKKFTCKNLGLIIIDEEQRFGVKEKEKLKEIRISVDCLALSATPIPRSLHMSLIKLRDISVLKIPPQNRVKIEAYLESFSELLIKHAIESELSRDGQVFLVNHNIEELYYLKTLIERLTPYARIAIIHGKLTGEEIENIMHNFIKKAYQILLATTIIENGIDIPNANTIIINNANKFGLAQLYQLKGRVGRGSQKAYAYFLYQDSEKLNERSIERLRAITEFSELGAGFKIAMKDMEIRGVGNLLGREQHGEIESIGLDYYLTMLNKAIEKKMGKISSDEEEVDIKINYSGFIPENYAKNEQDKILIYKKIFKIQTEEESKKIRSELHNDFGPIPEEINSLLMLAELKILAKDLNITKLKEKNRALEIEYKNIESIPMEKIIEILQKHPNLLILNPSYQKSIFLSFKNIEKSEKINYIYKNINLLKTST

mfd

Transcription-repair-coupling factor

1122 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

127.56 kDa

MLQQKFPAAAKSFFAIDNFTKNLKQDFILSASNEEEALQLYKQALFFSSNENIYYFPSYNTIPYDHTSPNANILSRRAETLIKLTTNNSNSNKLLITHTANLLNKLPPKDFFSKYFLKLSPKMKFTTDELAMFLVENSFTRNASSIDVGEFAVRGEIIDIILSGPKAYRIHFSWGYIESIKEFDIDTQISTKSCRELIISPANEIVLNSETIGNFKNNYLRNFGVNHTDNALYEAVISGRKFTGYEQLLPLFYDSCSNLIDYLNDPIFIFDNLSKKAILEFEHSYNDFYSARSEANKLKFNSFYPTLSPTSLYFTASEITELLEQKNNILLTFENSEQASLIKNIAATSFIEKKTVFDKLFEVIKANSHKKIIIGSSVLSSFERIKSIIQNYEYKYNEINKLDEAKASIINVAIIPLNQSFYTKEYLFITASELLEEKPSSTNTNKKLKNILLELDNLAEGEFVVHKDHGIGQFLKLEALEIKGKPHDFLKILYAGNDKLYIPVESIEVIKKYGNDNAELDKLGSVSWQRSKAKLKKRIKEIALHLIQIAAKRKLNSSASVEFDLEEYDKFCANFPFSETEDQLIAINDIKEDLRNGMLMDRLICGDVGFGKTEVAMRAVFMVAKSLNEHLPQVAVVVPTTILCSQHFSRFIERFKGFGLNIKQLSSVISSKEAKIIRSELESGKINIIIGTHSLLHKNIKFFNLKLLIIDEEQHFGVGQKEFLKSLKSSSHVLAMSATPIPRTLQMSMTGLKELSIIATPPLNRLEVHTSVMPYDPVIIRDALLREHFRGGRSFYVVPRIKDIEDIAKQLKQIVPELSYKIAYGKMTPSKIDEVMSEFYAGKFDILVSTTIIESGIDIAEANTMIIHNADMLGLSQLYQLRGRIGRGKMRGYAYLTVASHKKMTSHSLRRLEIIQNSCALGSGFTIASRDMDLRGFGNLIGEEQSGQIKEVGTELYQEMLEEQIAIFKDESIVSEQPFIPTINLGLSVFIPDNYVADAALKLGLYRRIGNLSNEIEVETFKDEMIDRFGLLPIEFNNLLDIVKIKLLCFKLNIENLDSGDNGFVIKFYKNADMTDKILKFVTTYSNQAKIKPDNKLVYIKKLVDKNIIVEANQLLWNLSEV

mfd

Transcription-repair-coupling factor

1120 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

127.304 kDa

MLQQKFPQAAKSFFTIDSFIKNSKQDFVLVTSNEEEALQLYKQALFFLPSENIYYFPSYDTIPYDHTSPNCNILSKRAETLSKLTTNKGNKLVITHATNLLNKLPPKDFFAKYYLKLFPKMKLSANELSKFLVENSFTRNASTVDVGEFAVRGEIVDLILPESKGYRINFSWDYVESIKQFDIDTQISTRSCNELIISPANEIVLNPETISNFKDNYLRNFGVNHTDNPLYEAITGGRKFSGYEQLLPLFYDSYSGLTDYLNNPVIIFDNLTKQAILEFEHSYNDFYKARLDANKLKFNSFYPTLSPSQLYFTSLEAIELLEQENNILISYENSEQASIVENIAAASFVEKKTIFDKLFEVIKANSRKKIIIGSSVLSSFERVKSIIENYEYSYNEIEYLEEAKTNTINIAILPLNQSFSTPEYLFIAASELLEEKVTPTNTNKKLKNILLELDHLAEGELIVHKDHGIGQFLKLEALEIKGKLHDFLKILYAGNDKLYIPVENIEVIKKYGSDVAQLDKLGSVSWQKNKAKLKNRIKEIALHLMQIAAKRKLNTTAAIEFDLEEYDKFCAKFPFTETEDQLNAINDIREDLSNGMLMDRLICGDVGFGKTEVAMRAAFMVAKSLNENSPQVAVVVPTTILCSQHFARFTERFKDSDLNIKQLSSVVSSKEAKIVRSELESGKINIIIGTHSLLHKVTKFCNLKLLIIDEEQHFGVGQKEFLKSLKSSTHVLAMSATPIPRTLQMSMTGLKELSIIATPPLNRLEVRTSVMPFDPVIIRDALLHEHFRGGKSFFVVPRINDIEDIEKQLKQIVPELSYKVAHGKMSPNKIDEIMSEFYAGKFDILISTTIIESGIDIQDANTMIIHKADMLGLSQLYQLRGRIGRGKMRGYAYLTLPSHKKMTPHSLRRLEIIQNSCALGSGFTIASHDMDLRGFGNLIGEEQSGQIREVGTELYQEMLEEQIAIFKDEPISGEQPFIPTINLGLSVFIPDNYVSDSVLKLGLYRRIGNLNDDLEVEKFKDEMIDRFGSLPTEFNNLLDIVKIKLLCFKLNIENLDSGDNGFVIKFYKNADMADKILKFVSTYTANAKIKPDNKLVFIKKLVGKTIITEANQLLWNLSEI

mfd

Transcription-repair-coupling factor

1120 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

127.676 kDa

MIQQKFPATAKCFYVIDNFTKNLNQDFILSVSNEEEALQLYKQALFFSSNDNIYYFPSYDTIPYDHTSPNANIVSRRAETLTKLITNSKGKLLITHAANLLNKLPPKDFFSKYFLKLYPKIKFTMDELSMLLVENSFTRNTSSIDVGEFAVRGEIIDIILPGPKGYRINFSWDYIESIKEFDINTQISTKYCAELVISPANEIVLNSETIGNFKNNYLRNFGVNHTDNPLYEAVISGRKFAGYEQLLPLFYYSCSSLVDYLNNPICIFDNLSKQAILEFENSYNDFYLARSKANKLKVNNFYPTLSPTSLYFTASAITELLEQKNNILISYENSEQASLIGNISSISFIEKKTIFDKLFEIIKANFHKKIIICSSVLSSFERIKSIIQNYEYTFNEINKLDEAKASVINIGIIPLNQSFYTKEYLFITSSELLEEKTLYTNTNKKLKNILLELDNLKEGEFVVHKDHGIGQFLKLEAFKIQGKLHDFLKILYFGNDKLYVPVENIEVIKKYGSDNAELNKLGSVAWNKSKAKLKNRIKEISLHLIQIAAKRKLNISTPIELDLEAYDKFCANFPFSETEDQLTAINDIREDLTNGMLMDRLICGDVGFGKTEVAMRAVFMVAKSLNEYLPQVAVVVPTTILCSQHFSRFIERFKGFGLNIKQLSSVISSKEANIIRLELASGKINIIIGTHALLHKNTKFFNLKLLIIDEEQHFGVSQKEFLKSLKSSTHVLAMSATPIPRTLQMSMTGLKELSIIATPPLNRLEVRTSVMPFDPVIIRDALLREHFRGGRSFYVAPRIKDMEDIEKQLKQIVPELSYKIAHGKMTPSKIDEVMSEFYVGKFDILISTTIIESGIDIAEANTMIIHKADTLGLSQLYQLRGRIGRGKIRGYAYLTVASNKKITSHSLRRLEIIQNSCSLGSGFTIASHDADLRGFGNLIGEEQSGQIKEVGTELYQEMLEEQIALLKDDPIVLEQAFIPNINLGLSVFIPDSYVSDSALKIGLYRRIGNLSNEMEVEKFKDEMIDRFGLLPIEFNNLLDIVKIKLLCFKLNIENLDSGDDGFVIRFYKNADMTDKILKFVSRYSNQTKIKPNNKLVFIKKLVDKNIITEVNQLLWTLLEI

mfd

Transcription-repair-coupling factor

1120 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

127.96 kDa

MLQQKFPATAKCFFAIDNFTKHLNQDFILSVNNEEEALKLYKQAFFFSSNENIYYFPSYDTIPYDYTSPNTNIISRRAETLTKLITNNNSKLLITHAANLLNKLPPKDFFSKYFLKLYPKIKFTIDELSMLLVENSFTRNISSNDVGEFSVRGEIIDIILPGPKAYRINFSWDYIESIKEFDINTQISTKYCTELVISPVSEIVLNSKTIGNFKNNYLRNFGVNHTDNPLYEAVISGRKFPGYEQLLPLFYDSCSSLVDYLNDPICIFDNLSKQEILEFENSCNDFYLARSNANKLKVNNFYPALSPASLYFTASAITELLEQKNNILISYENSEQASLIGNISSTSFMEKKTIFDKLFELIKANFHKKIIICSSVLSSFERIKSIIQNYKYTFNEINKLDDAKASVINIGIIPLNQSFYTKEYLFITSSELLEEKTLYTNTNKKLKNILLELDNLAEGEFVVHKDHGIGQFLKLEAFEIQGKLHDFLKILYSGNDKLYVPVENIEVIKKYGSNNVELDKLGSAAWHKSKAKLKDRIKEISLHLIQIAAKRKLNISTPIEFDLEEYDKFCANFPFIETEDQLTAINDIRKDLTNGMLMDRLICGDVGFGKTEVAMRAVFMVAKSLNEYLPQVAVVVPTTILCSQHFSRFIERFKGFGLNIKQLSSVVSSQEANIIRLELASGKINIIIGTHTLLHKNIKFFNLKLLIIDEEQHFGVSQKEFLKSLKYSSHVLAMSATPIPRTLQMSLTGLKELSIIATPPLNRLEVRTSVMPFDTVIIRDALLREHFRGGRSFYVVPRIKDMEDIEKQLKQIVPELSYKIAHGKMTPSKIDEVMSEFYAGKFDILISTTIIESGIDITEANTMIIHNADTLGLSQLYQLRGRIGRGKIRGYAYLTVASNKKLMQHSLRRLEIIQNSCALGSGFTIASHDADLRGFGNLIGEEQSGQIREVGAELYQEMLEEQIALLKDESIVSEQSFIPNINLGLSVFIPDHYVSDSALKIALYRRIGNLSNEIEVEKFKDEMIDRFGLLPIEFNNLLDIVKIKLLCFKLNIENLDSGDDGFVIRFYKNADMSDKILKFVSRYSNQTKIKPNNKLVFIKKLVDKNIITEANQLLWTLLEI

mfd

Transcription-repair-coupling factor

1001 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

113.437 kDa

MIQSSLYRALNKGFDYQILACKDFKESELAKEVISYFKPNIKAVLFPELRAKKNDDLRSFFEEFLQLLGGLREFYQALENKQETIIIAPISALLHPLPKKELLESFKITLLEKYNLKDLKDKLFYYGYEILDLVEVEGEASFRGDIVDIYIPNSKAYRLSFFDAECESIKELDPATQMSLKEDLLEIEIPPTLFSLDEPSYKDLKTKVEQSPLNSFSKDLTSFGLWFLGEKANDLLGVYQSIISPRALEEIQELASLNELDDERFKFLKVLENAQGYEDLEIHVHALEGFIALHSNRKITLLAPNKTILDNSISVLDAGNMECVIAPFVLNFKTPDRIFISLNSFERKKKRQKSKLALNELNAGEWVVHDDYGVGVFSQLIQHSVLGSKRDFLEIAYLGEDKLLLPVENLHLIARYVVQSDSVPVKDRLGKGSFLKLKAKVRAKLLEIAGKIIELAAERNLILGKKMDTHLAELEIFKSHAGFEYTSDQEKAIAEISRDLSSHRVMDRLLSGDVGFGKTEVAMHAIFCAFLNGFQSALVVPTTLLAHQHFETLKARFENFGVKVARLDRYIKTSEKSKLLKAVELGLVDVLIGTHAILGTKFKNLGLMVVDEEHKFGVKQKEALKELSKSVHFLSMSATPIPRTLNMALSQIKGISSLKTPPTDRKPSRTFLKEKNDELLKEIIYRELRRNGQIFYIHNHIASISKVKTKLEDLIPKLKIAILHSQINANESEEIMLEFAKGNYQVLLCTSIVESGIHLPNANTIIIDNAQNFGLADLHQLRGRVGRGKKEGFCYFLIEDQKSLNEQALKRLLALEKNSYLGSGESIAYHDLEIRGGGNLLGQDQSGHIKNIGYALYTRMLEDAIYELSGGKKRLEKSVEIQLGVSAFLNPELIASDSLRLDLYRRLSLCENVDEVGQIHEEIEDRFGKMDDLSAQFLQIITLKILANQLGILKLSNFNQNITLTYSDEKKESLKAPSKDDNDILETLLKHLHAQISLKRR

mfd

Transcription-repair-coupling factor

999 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

113.09 kDa

MIQSSLYRALNKGFDYQILACKDFKESELAKEVISYFKPNTKAILFPEFRAKKNDDLRSFFEEFLQLLGGLREFYQALENKQETIIIAPISALLHPLPKKELLESFKITLLEKYNLKDLKDKLFYYGYEILDLVEVEGEASFRGDIVDIYAPNSKAYRLSFFDTECESIKEFDPITQMSLKEDLLEIEIPPTLFSLDESSYKDLKTKVEQSPLNSFSKDLTSFGLWFLGEKAQDLLIVYKSIISPRALEEIQELASLNELDCERFKFLKVLENAQGYEDLEIHAHALEGFIALHSNHKITLLAPNKTILDNAISALDAGNMECVIAPFVLNFKTPDGIFISLNSFERKKKRQKSKLALNELNPGEWVVHDDYGVGVFSQLVQHSVLGSKRDFLEIAYLGEDKLLLPVENLHLIARYVAQSDSVPAKDRLGKGSFLKLKAKVRTKLLEIASKIIELAAERNLILGKKMDVHLAELEVFKSHAGFEYTSDQEKAIAEISKDLSSHRVMDRLLSGDVGFGKTEVAMHAIFCAFLNGFQSALVVPTTLLAHQHFETLRARFENFGVKVARLDRYASEKNKLLKAVELGQVDALIGTHAILGAKFKNLGLVVVDEEHKFGVKQKEALKELSKSVHFLSMSATPIPRTLNMALSQIKGISSLKTPPTDRKPSRTFLKEKNDELLKEIIYRELRRNGQIFYIHNHIASILKVKTKLEDLIPKLKIAILHSQINANESEEIMLEFAKGNYQVLLCTSIVESGIHLPNANTIIIDNAQNFGLADLHQLRGRVGRGKKEGFCYFLIEDQKSLNEQALKRLLALEKNSYLGSGESVAYHDLEIRGGGNLLGQDQSGHIKNIGYALYTRMLEDAIYELSGGKKRLEKSVEIQLGVSAFLNPELIASDSLRLDLYRRLSLCENTDEVGQIHEEIEDRFGKIDDLSAQFLQIITLKILANQLGIIKLSNFNQNITITYSDEKKESLKAPSKDDNDILETLLKHLRAQISLKRR

mfd

Transcription-repair-coupling factor

812 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site (By similarity).

In the C-terminal section; belongs to the helicase family. RecG subfamily.

93.881 kDa

MKITKNKILKNKKIINFKYQKLLDLFYNVNNQKKNNQLLSYLYSFSGKIIFSLTEEKSLKKILRFLMRHKIHPQYIKRIIDIKKEIDYFYMIEEIKNGFIDKKNNILFLCTKDLLPILIDDKYIGNIKKNTNNINKFNLSQLILNHPVMHIEHGIGRYKGLTTIETASIQSEYLVISYAEGDKLYVPVSNLHLVSPYTGTSIENAPLHKLGGDDWNKEKHKISKTVYDHAAQLLHIYAKRESKTGFAFKKNIEKYDLFCNDCSFKTTSDQNEVMKFVLKDMSKPIPMDRLICGDVGFGKTEIAMRASFLAVSNKKQVAILVPTTLLAQQHYKNFKIRFSNWPVNINILSRFQTQKEQDLIFKHTKNGRINIIIGTHKLLFKNIEWCSLGLLIIDEEHRFGVSHKEIIKKIYSNIDILTLTATPIPRTLNMAMTGIKDLSIIAKPPAQRLAIKTFIQEYSPILIRKTILREISRGGQVYYIYNKVQNIMNIAERLSILIPEASIKIGHGQMKNIDLKKVMNEFYNNKFNVLICTTIIESGVDIARANTIIIENSDHFGLSQLHQLRGRIGRSNNQAYALLLVNNFNKITSDAKKRLEAISSVDNFGGGFSLSNQDLEIRGVGEILGKEQSGHIKNIGFSLYMDLLKNAIDLLKNGKIFSVEKSLKKPLEIDLHVSSLLPSSYILDINTRLFFYKKLANAIHEKQIEEIKYELIDQFGKLPDFSKNLILIAKIRLIADKIGIKYIKSNNNIGIIEFNDYGSINTEYLLKMFQKEPKIWKMETSTRIKFILHLKNDYLRLKWIINLLRNLFKKNI

mfd

Transcription-repair-coupling factor

697 amino acids

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site (By similarity).

In the C-terminal section; belongs to the helicase family. RecG subfamily.

80.419 kDa

MLIKSLVQKNQVYFTNNSLDEKNICDLSKLKINQPIVHFEHGVGRYQGLTTVTTRNIKTECVVINYAQNSKLYVPITYLYLISRYIGTSKKDIPLHRLGNDLWNKEKKKANEKAYDSAAILLNIYSHRISQKGFSFKKHHTKYKIFCERFPFTLTPDQDSAINSVLSDMYKSTPMDRLVCGDVGFGKTEVAMRATFLAVCNQKQVAILVPTTLLAQQHFNNFTLRFKYWSTKIEILSRFQSETKCNEIINNVNIGNVHVLIGTHKILLKNLKWKNLGLLIVDEEHRFGVHHKEQIKLISNNIDVLTLTATPIPRTLNMAFVGIRDLSIIATPPKQRLIVKTFVREFSYTVIRKAILREILRGGQVYYIYNNVNKIERKKIELKKLVPEANIRIGHGQLRSTDLESIMNDFYHKRFNVLVCSTIIETGIDIPNVNTIIIENANNFGLAQLHQLRGRVGRSQHQAYAWLLVPSLKDIKSDAKKRIDAITSIESFGSCFELANRDLEIRGIGEILGNNQSGHITKIGFSLYMKLLMNAVRNIKNGYYKPLNDIINTYPKIELNVSNLLPDSYIKKVNHRLFFYNKIATSNNFLDLEKIRLTLCKNFGNLPNSGDYLIKIAKIRLISKKIGVKKIKSDVKGGYIEFFEDSKINIQNLLKEFKKEKNCWKFDTSNRLRFSKNFKNNSERIDWILNMLININN