mettl1

tRNA (guanine-N(7)-)-methyltransferase

278 amino acids

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.

32.423 kDa

MVYQKQEPKKKKAIKPYHRIKAHANPASDYNFYYPTGPESYDWTKNYPQQAMNEKKVEIADVGCGYGGLLISLSSLFPERLSVGMELRDKVVQYVEERIDKLREKHVGQFQNISVIRTNAMKYLPNYFEKGQLQKIFFLFPDPHFKKATHKRRIISPTLLSEYAYILAPGAYAYFISDVEELYLWMFEHFKNHPLFEQVERDIAENDSCIPLIVNSTEEGRKVNRIDGKKWFAVFRRITDPSKKDLTFKNYTLTSPKEIDSTTTTTTSTATITEVESK

METTL1

tRNA (guanine-N(7)-)-methyltransferase

277 amino acids

Methyltransferase that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs. Internal N(7)-methylguanine methylation of mRNAs regulates translation. Also methylates a specific subset of miRNAs, such as let-7. N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA). Acts as a regulator of embryonic stem cell self-renewal and differentiation.

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.

31.323 kDa

MAGTETGDAAGTEAPQPQKRYYRQRAHSNPMADHTLRYPVKPEDMDWSELYPEFFAPLPQNQSHDDPKDKKEKRAQAQVEFADIGCGYGGLLVELSPLFPDTLILGLEIRVKVSDYVQDRIRALRAAPGGGFQNIACLRSNAMKHLPNFFHKGQLTKMFFLFPDPHFKRTKHKWRIISPTLLAEYAYVLRVGGLVYTITDVLELHEWMCTHFEGHPLFERVPLEELSEDPIVGHLGTSTEEGKKVLRNGGKNFPAIFRRIQDPALPAVTPTPTPPGH

METTL1

tRNA (guanine-N(7)-)-methyltransferase

276 amino acids

Methyltransferase that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (PubMed:12403464, PubMed:31031084). Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs (PubMed:31031084). Internal N(7)-methylguanine methylation of mRNAs regulates translation (PubMed:31031084). Also methylates a specific subset of miRNAs, such as let-7 (PubMed:31031083). N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) (PubMed:31031083). Acts as a regulator of embryonic stem cell self-renewal and differentiation (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.

31.471 kDa

MAAETRNVAGAEAPPPQKRYYRQRAHSNPMADHTLRYPVKPEEMDWSELYPEFFAPLTQNQSHDDPKDKKEKRAQAQVEFADIGCGYGGLLVELSPLFPDTLILGLEIRVKVSDYVQDRIRALRAAPAGGFQNIACLRSNAMKHLPNFFYKGQLTKMFFLFPDPHFKRTKHKWRIISPTLLAEYAYVLRVGGLVYTITDVLELHDWMCTHFEEHPLFERVPLEDLSEDPVVGHLGTSTEEGKKVLRNGGKNFPAIFRRIQDPVLQAVTSQTSLPGH

mettl1

tRNA (guanine-N(7)-)-methyltransferase

273 amino acids

Methyltransferase that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs. Internal N(7)-methylguanine methylation of mRNAs regulates translation. Also methylates a specific subset of miRNAs.

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.

31.843 kDa

MADTQAMASDRGVAVTLPQKRYYRQRAHSNPMADHTFQYPVKPEVMDWSEYYPEFFKPLVPDCAHDDAKDLQERKEQHQVEFADVGCGYGGLLVALSPLFPNTLMLGLEIRVKVSDYVQDRIKSLRASHLGQYQNIACIRSNAMKYLPNFFKKGQLSKMFFLFPDPHFKKTKHKWRIISPTLLAEYSYALRVGGMVYTITDVEEVHEWMVKHFTEHPLFERVEKEELVSDIIVDKLGTSTEEGKKVQRNKGQNFLAVFRRIENRTFIQRDSQQ

Mettl1

tRNA (guanine-N(7)-)-methyltransferase

268 amino acids

Methyltransferase that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:29983320). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs (PubMed:29983320). Internal N(7)-methylguanine methylation of mRNAs regulates translation (PubMed:29983320). Also methylates a specific subset of miRNAs, such as let-7. N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) (By similarity). Acts as a regulator of embryonic stem cell self-renewal and differentiation (PubMed:29983320).

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.

30.603 kDa

MMAGAEAPQPQKRYYRQRAHSNPMADHTLRYPVKPEEMDWSELYPEFFAPLIQNKSHDDPKDEKEKHSGAQVEFADIGCGYGGLLVALSPLFPDTLILGLEIRVKVSDYVQDRIRALRAAPGGGFQNIACLRSNAMKHLPNFFRKGQLAKMFFLFPDPHFKRTKHKWRIISPTLLAEYAYVLRVGGLVYTVTDVPELHEWMCTHFEEHPLFERVPLEELSEDPIVEHLGSSTEEGKKVLRNGGKNFPAVFRRIQDPLLQAVTPNPTLP

mettl1

tRNA (guanine-N(7)-)-methyltransferase

241 amino acids

Methyltransferase that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs. Internal N(7)-methylguanine methylation of mRNAs regulates translation. Also methylates a specific subset of miRNAs.

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.

27.966 kDa

MSVCMPQKRYYRQRAHSNPMADHTFQYPVCPEQMDWSPLYPQYFPQQEEAGGAQVEFADIGCGYGGLLVQLSQLFPQQLILGLEIRVKVSDYVQDRIRSLRVAEPGRYQNIACLRSNAMKYLPNFFRKGQLSKMFFLFPDPHFKKTKHKWRIISPTLLAEYAYTLRIGGLVYTNTDVEEVHEWIVQHFSDHPLFSRVTEEQLADDIIVGHLGTCTEEGKKVQRNGGKNFLAVFRRVEDPQT