Protein
Homoserine O-acetyltransferase
Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Function
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine (PubMed:17927957, PubMed:28581482). Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine (PubMed:17927957).
Similarity
Belongs to the AB hydrolase superfamily. MetX family.
Sequence
MNETGSIGIIETKYAEFKELILNNGSVLSPVVIAYETYGTLSSSKNNAILICHALSGDAHAAGYHSGSDKKPGWWDDYIGPGKSFDTNQYFIICSNVIGGCKGSSGPLSIHPETSTPYGSRFPFVSIQDMVKAQKLLVESLGIEKLFCVAGGSMGGMQALEWSIAYPNSLSNCIVMASTAEHSAMQIAFNEVGRQAILSDPNWKNGLYDENSPRKGLALARMVGHITYLSDDKMREKFGRNPPRGNILSTDFAVGSYLIYQGESFVDRFDANSYIYVTKALDHYSLGKGKELTAALSNATCRFLVVSYSSDWLYPPAQSREIVKSLEAADKRVFYVELQSGEGHDSFLLKNPKQIEILKGFLENPN