Protein
Dual specificity mitogen-activated protein kinase kinase 1
Organism
Dictyostelium discoideum
Function
Required for cAMP-mediated activation of guanylyl cyclase activity and plays an essential role in aggregation, morphogenesis, and chemotaxis. Appears to act upstream of erk1 but not erk2.
Similarity
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Sequence
MNTNTNTNTNISSSGNNIINTPTTNNNNKNNNNNNNNNNNSNNSNNNSSNNNNNNNNAVGVKTGKKVNLKVETPVQNNENSYSLTTSGTFKEGDLLINKKGLLIKGESPKNSSVNDRNKNKSLHSNLNPQLLASPTSSESMDFNQGFYNNNNNNNNNNNNNNLNNFNNLMNNGIDSPQLSGISISTPTSSHSFNNTFTNYYNNNNNYNNYNNNNNSNNNNNNYNNSNNNFNNFNNYNNYGNNNNFNNFNALQSSSNSSFDISSSGSSNNYLNNSANNHPHYDTNLSYDLKDLKIIRVLGRGAGGVVKLAYHETSGTYIALKVITLDIQENIRKQIILELKTLHKTSYPYIVSFYDAFYTEGSIFIALEFMELGSLSDIMKKTSTIPEPVLGKIAFQVLQGLVYLHRKLHLIHRDIKPSNILVNNKGEAKIADFGVSGQLQHTLSKAVTWVGTVTYMSPERISGRSYSFDSEIWSLGLTILECAIGKFPYGSNLPHQQQQPLQQQQQQQQQQQQPLQQQQQQQQQQQQPLQLQLQNLDINNSNNNIRNSNNNNNNNNNNNNNNNNNNNNNVLDISNGGLVDSGSSVPEGMGFWVLLDCIVKEEVPILPSTFSKEFRSFISECLQKEPTERPTASNLLNHEFVKKYQNFNVEKWTANLKQQQ