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mefA

Gene
mefA
Protein
Macrolide efflux protein A
Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Length
405 amino acids
Function
Confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides but not to 16-membered macrolides, lincosamides or analogs of streptogramin B. May function as an efflux pump to regulate intracellular macrolide levels (By similarity).
Similarity
Belongs to the major facilitator superfamily. Drug:H(+) antiporter-3 (DHA3) (TC 2.A.1.21) family.
Mass
44.279 kDa
Sequence
MEKYNNWKLKFYTIWAGQAVSLITSAILQMAIIFYLTEKTGSAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSVLTIVAFYMELPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAIIAIDVLGAVIASITVAIVRIPKLGDRVQSLDPNFIREMQEGMAVLRQNKGLFALLLVGTLYMFVYMPINALFPLISMDYFNGTPVHISITEISFASGMLIGGLLLGLFGNYQKRILLITASIFMMGISLTISGLLPQSGFFIFVVCCAIMGLSVPFYSGVQTALFQEKIKPEYLGRVFSLTGSIMSLAMPIGLILSALFADRIGVNHWFLLSGTLIICIAIVCPMINEIRKLDLK

Gene
mefA
Protein
Macrolide efflux protein A
Organism
Streptococcus pyogenes
Length
405 amino acids
Function
Confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides but not to 16-membered macrolides, lincosamides or analogs of streptogramin B. May function as an efflux pump to regulate intracellular macrolide levels.
Similarity
Belongs to the major facilitator superfamily. Drug:H(+) antiporter-3 (DHA3) (TC 2.A.1.21) family.
Mass
44.279 kDa
Sequence
MEKYNNWKLKFYTIWAGQAVSLITSAILQMAIIFYLTEKTGSAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSVLTIVAFYMELPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAIIAIDVLGAVIASITVAIVRIPKLGDRVQSLDPNFIREMQEGMAVLRQNKGLFALLLVGTLYMFVYMPINALFPLISMDYFNGTPVHISITEISFASGMLIGGLLLGLFGNYQKRILLITASIFMMGISLTISGLLPQSGFFIFVVCCAIMGLSVPFYSGVQTALFQEKIKPEYLGRVFSLTGSIMSLAMPIGLILSALFADRIGVNHWFLLSGTLIICIAIVCPMINEIRKLDLK

Gene
mefA
Protein
Macrolide efflux protein A
Organism
Enterococcus faecalis
Length
323 amino acids
Function
Confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides but not to 16-membered macrolides, lincosamides or analogs of streptogramin B. May function as an efflux pump to regulate intracellular macrolide levels (By similarity).
Similarity
Belongs to the major facilitator superfamily. Drug:H(+) antiporter-3 (DHA3) (TC 2.A.1.21) family.
Mass
34.947 kDa
Fragment
single
Sequence
MGSAMVLSMSLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSVLTIVAFYMELPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAIIAIDVLGAVIASITVLIVRIPKLGDRVQSLDPNFIREMQEGMAVLRQNKGLFALLLVGTLYMFVYMPINALFPLISMDYFNGTPVHISITEISFASGMLIGGLLLGLFGNYQKRILLITASIFMMGISLTISGLLPQSGFFIFVVCSAIMGLSVPFYSGVQTALFQEKIKPEYLGRVFSLTGSIMSLAMPIGL