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mdt-8

Gene
mdt-8
Protein
Mediator of RNA polymerase II transcription subunit 8
Organism
Caenorhabditis elegans
Length
297 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 8 family.
Mass
33.438 kDa
Sequence
MEYPNPPPPVTSNYQGEPEKIAQATDMMIKRVTDAKKIIEELLQMLDLQEKCPWPLMLEKFSTLASFMSSLQSSVRKSGMPHGHEDYGQFLRSHVLVTQRLQYEPDETLQRATQGRVMSWNHALVPEYLRTKPNPEMENEEGMLDGERSAKSADLVVRQIAAYNKNIEGLINHLNSVDRMHTEAAIEKPTYNRDETAKIVKSILTGEGIRSQRTMAPAPPSSAPMTTAPSSTGPSSSQPISGNQPEYQGSQLRQQLSGGQPQTSQAHLPMYSHHQQPQYSHQQPMNPQHHSPMKFQQ