Protein
Mediator of RNA polymerase II transcription subunit 15
Organism
Caenorhabditis briggsae
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes.
Similarity
Belongs to the Mediator complex subunit 15 family.
Sequence
MSEEDWPSPKFREHVIQRLEPELARNRQNAPNLPVPGDARQVEEYVFAKCMSKDEYMRTIAKVINAINCNSKSAAVPSVLQPSQFHSPPCTTAVLGTGVGTPGYRAPVPPDPQPTSAQARNPPVTTATTQASTTPSAPAVTGTVSASAAVAAAVASFPSPDSAALRAAPGGQTTPGSQPSSGAPGSTTPNAPFPNGAGAQPGAPTMNGGAGGPPMGQPPPQMGAPNMGMNGPGGYGGYGMMNGPPGAGGPMGGNPYGQPMKKEMDQSRGPWDPQGHMYQQQQPWGGMPPQQGHGGYPNRPMNGQQTTPTGTSSVLESLINQPQQYPGHHNQMAPPGGDRNAAGGRAGVPGNPGGVPGAPQRPGAMPVNQGVMSIEDQNVYQMKLRNMRGSCDSLRTRARQCRQEGNHEAAHKLEVMLSVLEGRRVVSLEYLNHLETWIARKQDFLNINPMGGGNPGHMGMNDPVMNGDHGMMSNGQVHNPYGHPGYNHGQYGMGGPPPPHHMQMHQQQMWQQPQQQRMMPTDPMMMGGGGPMHGGPMYRGDMGHEMNSPVNSHRHNPYPSPAAMRNNMRGMQNGPGPIGRDRNSMSGSMSGPSSGAPSLNTMGTPKMGAPGSIGGLSNLDDFTYDDFLPNPIDALQPTLHIGPGSSMGGGPRVNLNDAARKELQAMEGRFEIEPNHQRHDANHIIVSAKMRNQPVPPLRLVVPITYPSGNVTVDRTAIDLDAYLYDDLQNVVHERLSRPGLSSLTDYLNAWEEQVNQYMQQNQTNGGMDAAFGVGNDFFYDNLNL