mdr2

Gene

MDR2

Protein

ABC multidrug transporter MDR2

Organism

Trichophyton equinum (strain ATCC MYA-4606 / CBS 127.97)

Length

1331 amino acids

Function

Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds.

Similarity

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

Mass

145.322 kDa

Sequence

MVEVSEKPNTQDDGVSKQENRNPASSSSSTSDKEKVAKKGNSDATKSSTPEDLDAQLAHLPEHEREILKQQLFIPDVKATYGTLFRYATRNDMIFLAIVSLASIAAGAALPLFTVLFGSLAGTFRDIALHRITYDEFNSILTRNSLYFVYLGIAQFILLYVSTVGFIYVGEHITQKIRAKYLHAILRQNIGFFDKLGAGEVTTRITADTNLIQDGISEKVGLTLTALSTFFSAFIIGYVRYWKLALICSSTIVAMILVMGGISRFVVKSGRMTLVSYGEGGTVAEEVISSIRNATAFGTQEKLARQYEVHLKEARKWGRRLQMMLGIMFGSMMAIMYSNYGLGFWMGSRFLVGGETDLSAIVNILLAIVIGSFSIGNVAPNTQAFASAISAGAKIFSTIDRVSAIDPGSDEGDTIENVEGTIEFRGIKHIYPSRPEVVVMEDINLVVPKGKTTALVGPSGSGKSTVVGLLERFYNPVSGSVLLDGRDIKTLNLRWLRQQISLVSQEPTLFGTTIFENIRLGLIGSPMENESEEQIKERIVSAAKEANAHDFIMGLPDGYATDVGQRGFLLSGGQKQRIAIARAIVSDPKILLLDEATSALDTKSEGVVQAALDAASRGRTTIVIAHRLSTIKSADNIVVIVGGRIAEQGTHDELVDKKGTYLQLVEAQKINEERGEESEDEAVLEKEKEISRQISVPAKSVNSGKYPDEDVEANLGRIDTKKSLSSVILSQKRSQENETEYSLGTLIRFIAGFNKPERLIMLCGFFFAVLSGAGQPVQSVFFAKGITTLSLPPSLYGKLREDANFWSLMFLMLGLVQLVTQSAQGVIFAICSESLIYRARSKSFRAMLRQDIAFFDLPENSTGALTSFLSTETKHLSGVSGATLGTILMVSTTLIVALTVALAFGWKLALVCISTVPVLLLCGFYRFWILAQFQTRAKKAYESSASYACEATSSIRTVASLTREQGVMEIYEGQLNDQAKKSLRSVAKSSLLYAASQSFSFFCLALGFWYGGGLLGKGEYNAFQFFLCISCVIFGSQSAGIVFSFSPDMGKAKSAAADFKRLFDRVPTIDIESPDGEKLETVEGTIEFRDVHFRYPTRPEQPVLRGLNLTVKPGQYIALVGPSGCGKSTTIALVERFYDTLSGGVYIDGKDISRLNVNSYRSHLALVSQEPTLYQGTIRDNVLLGVDRDELPDEQVFAACKAANIYDFIMSLPDGFGTVVGSKGSMLSGGQKQRIAIARALIRDPKVLLLDEATSALDSESEKVVQAALDAAAKGRTTIAVAHRLSTIQKADIIYVFDQGRIVESGTHHELLQNKGRYYELVHMQSLEKTQ

Protein

ABC multidrug transporter MDR2: MDR2

Gene

MDR2

Protein

ABC multidrug transporter MDR2

Organism

Trichophyton interdigitale (strain MR816)

Length

1331 amino acids

Function

Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds, including terbinafine, 4-nitroquinoline N-oxide, and ethidium bromide (PubMed:16849730). May play a role in pathogenicity (PubMed:19141731).

Similarity

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

Mass

145.28 kDa

Sequence

MVEVSEKPNTQDDGVSKQENRNPASSSSSTSDKEKVAKKGNSDATKSSTPEDLDAQLAHLPEHEREILKQQLFIPDAKATYGTLFRYATRNDMIFLAIVSLASIAAGAALPLFTVLFGSLAGTFRDIALHRITYDEFNSILTRNSLYFVYLGIAQFILLYVSTVGFIYVGEHITQKIRAKYLHAILRQNIGFFDKLGAGEVTTRITADTNLIQDGISEKVGLTLTALSTFFSAFIIGYVRYWKLALICSSTIVAMILVMGGISRFVVKSGRMTLVSYGEGGTVAEEVISSIRNATAFGTQEKLARQYEVHLKEARKWGRRLQMMLGIMFGSMMAIMYSNYGLGFWMGSRFLVGGETDLSAIVNILLAIVIGSFSIGNVAPNTQAFASAISAGAKIFSTIDRVSAIDPGSDEGDTIENVEGTIEFRGIKHIYPSRPEVVVMEDINLVVPKGKTTALVGPSGSGKSTVVGLLERFYNPVSGSVLLDGRDIKTLNLRWLRQQISLVSQEPTLFGTTIFENIRLGLIGSPMENESEEQIKERIVSAAKEANAHDFIMGLPDGYATDVGQRGFLLSGGQKQRIAIARAIVSDPKILLLDEATSALDTKSEGVVQAALDAASRGRTTIVIAHRLSTIKSADNIVVIVGGRIAEQGTHDELVDKKGTYLQLVEAQKINEERGEESEDEAVLEKEKEISRQISVPAKSVNSGKYPDEDVEANLGRIDTKKSLSSVILSQKRSQEKETEYSLGTLIRFIAGFNKPERLIMLCGFFFAVLSGAGQPVQSVFFAKGITTLSLPPSLYGKLREDANFWSLMFLMLGLVQLVTQSAQGVIFAICSESLIYRARSKSFRAMLRQDIAFFDLPENSTGALTSFLSTETKHLSGVSGATLGTILMVSTTLIVALTVALAFGWKLALVCISTVPVLLLCGFYRFWILAQFQTRAKKAYESSASYACEATSSIRTVASLTREQGVMEIYEGQLNDQAKKSLRSVAKSSLLYAASQSFSFFCLALGFWYGGGLLGKGEYNAFQFFLCISCVIFGSQSAGIVFSFSPDMGKAKSAAADFKRLFDRVPTIDIESPDGEKLETVEGTIEFRDVHFRYPTRPEQPVLRGLNLTVKPGQYIALVGPSGCGKSTTIALVERFYDTLSGGVYIDGKDISRLNVNSYRSHLALVSQEPTLYQGTIRDNVLLGVDRDDVPDEQVFAACKAANIYDFIMSLPDGFGTVVGSKGSMLSGGQKQRIAIARALIRDPKVLLLDEATSALDSESEKVVQAALDAAAKGRTTIAVAHRLSTIQKADIIYVFDQGRIVESGTHHELLQNKGRYYELVHMQSLEKTQ

Protein

ABC multidrug transporter MDR2: MDR2

Gene

MDR2

Protein

ABC multidrug transporter MDR2

Organism

Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892)

Length

1331 amino acids

Function

Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds.

Similarity

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

Mass

145.439 kDa

Sequence

MVEPSEKPNTQNDDVSKQEIRNPVSSSSSTSDKEKVAKKGNSDATKSLTPEDLDAQLAHLPEHEREILKQQLFIPEVKATYGTLFRYATRNDMILLAIVSLASIAAGAALPLFTVLFGSLAGTFRDIALHRITYDEFNSILTRNSLYFVYLGIAQFILLYVSTVGFIYVGEHITQKIRARYLHAILRQNIGFFDKLGAGEVTTRITADTNLIQDGISEKVGLTLTALSTFFSAFIIGYVRYWKLALICTSTIVAMVLVMGGISRFVVKSGRMTLVSYGEGGTVAEEVISSIRNATAFGTQEKLARQYEVHLREARKWGRRLQMMLGIMFGSMMAIMYSNYGLGFWMGSRFLVGGETDLSAIVNILLAIVIGSFSIGNVAPNTQAFASAISAGAKIFSTIDRVSAIDPGSDEGDTIENVEGTIEFRGIKHIYPSRPEVVVMEDINLVVPKGKTTALVGPSGSGKSTVVGLLERFYNPVAGSVFLDGRDIKTLNLRWLRQQISLVSQEPTLFGTTIFENIRLGLIGSPMENESEEQIKERIVSAAKEANAHDFVMGLPDGYATDVGQRGFLLSGGQKQRIAIARAIVSDPKILLLDEATSALDTKSEGVVQAALDAASRGRTTIVIAHRLSTIKSADNIVVIVGGRIAEQGTHDELVDKKGTYLQLVEAQKINEERGEESEDEAVLEKEKEISRQISVPAKSVNSGKYPDEDVEANLGRIDTKKSLSSVILSQKRGQEKETEYSLGTLIRFIAGFNKPERLIMLCGFFFAVLSGAGQPVQSVFFAKGITTLSLPPSLYGKLREDANFWSLMFLMLGLVQLITQSAQGVIFALCSESLIYRARSKSFRAMLRQDIAFFDLSENSTGALTSFLSTETKHLSGVSGATLGTILMVSTTLIVALTVALAFGWKLALVCISTVPVLLLCGFYRFWILAQFQTRAKKAYESSASYACEATSSIRTVASLTRENGVMEIYEGQLNDQAKKSLRSVAKSSLLYAASQSFSFFCLALGFWYGGGLLGKGEYNAFQFFLCISCVIFGSQSAGIVFSFSPDMGKAKSAAADFKRLFDRVPTIDIESPDGEKLETVEGTIEFRDVHFRYPTRPEQPVLRGLNLTVKPGQYIALVGPSGCGKSTTIALVERFYDTLSGGVYIDGKDISRLNVNSYRSHLALVSQEPTLYQGTIRDNVLLGVDRDDVPDEQVFAACKAANIYDFIMSLPDGFATVVGSKGSMLSGGQKQRIAIARALIRDPKVLLLDEATSALDSESEKVVQAALDAAAKGRTTIAVAHRLSTIQKADIIYVFDQGRIVESGTHHELLQNKGRYYELVHMQSLEKTH

Protein

ABC multidrug transporter MDR2: MDR2

Gene

MDR2

Protein

ABC multidrug transporter MDR2

Organism

Trichophyton tonsurans (strain CBS 112818)

Length

1331 amino acids

Function

Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds.

Similarity

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

Mass

145.322 kDa

Sequence

Protein

ABC multidrug transporter MDR2: MDR2

Gene

mdr2

Protein

ABC multidrug transporter mdr2

Organism

Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)

Length

791 amino acids

Function

Pleiotropic ABC efflux transporter that may be involved in A.fumigatus adaptation to azoles.

Similarity

Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.

Mass

85.169 kDa

Sequence

MRGIRSLPCWAPGLSTKRIPPRELFADLFPNACVISARHSARNGLIRQFSGCSGSISNSCNPRPYRSAITSLLSANVCSKGVSAVQPRFLSTVRLFSTSQRSLEPKSNVKSTGGQVVRPELHQDQEHEDIEKGFELSERAAQAAQVNLSAKLAKDGAAGKKAGFKEIWRLLLIARPEAKKLALAFLFLLVSSGITMSIPFSIGKIMDTSTKATTEGGNELFGLSLPMFYGALAGILTLGAAANYGRIIILRIVGERIVARLRSKLFRQTFVQDAEFFDANRVGDLISRLSSDTIIVGKSITQNLSDGLRAAVSGAAGFGLMAYVSLKLSSILALLLPPIGLGAFFYGRAIRNLSRQIQRNLGTLTKIAEERLGNVKTSQSFAGEVLEVRRYNNQVRKIFELGKKESLISATFFSSTGFAGNMTILALLYVGGGMVQSGAITIGELTSFLMYTAYAGSSMFGLSSFYSELMKGVGAASRLFELQDRQPTISPTKGEKVASARGPIRFENVTFSYPTRPAVPIFRDLNFEIPQGTNVAIVGPSGGGKSTIASILLRFYSPTEGRVLIGGKDITHMNAKSLRRKIGIVSQEPVLFSGTIAENIAYGKPQAKRSEIVAAARKANCQFISDFPDGLDTQVGPRGAQLSGGQKQRIAIARALIKDPDILILDEATSALDAESETLVNSALTALLRGNNTTISIAHRLSTIKRSDTIIVLGPDGRVAEQGSYEELSARPDGAFTKLMEWQMSGGEVMDQLANTPANPVAQETSWDLQSDDGTEISEDTNIPSEPRTID

Protein

ABC multidrug transporter mdr2: mdr2