Protein
Mitochondrial distribution and morphology protein 34-2
Organism
Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)
Function
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10.
Similarity
Belongs to the MDM34 family.
Sequence
MAFNFNWSPLMADASFYTRAQDLLTAALNKSPKPPIIVDDIHVTELNLGSIPPELEILEIGDLAEDRFRGIFKMSYTGDAFLTLKTRVQANPLNTFLLTRPTFGSPVPLAAATPLTIPLQITLSDFKLSGFVILVFSKQKGITVVFRNDPLESLKVSSTFDSIPFVRDFLQKEIEAQLRILFMDELPAIIHRLSLRLWVPEYRTGEEMNDETDNTAKSSEGPGQDPLASPPQDPVDSLGNALNESEIASLSLDSSVETHSLFSQKNLLRLAALTDSQRTLSLFTPSIQEVVYRAWTSPTDTSEFPSSVISPLSPTLSREQSQMGSMSSLHETASNASMQSRPSMSSHSFSTSTYGLSLGAGRHSKAHARKRKKRVVDLRRPKTTDDAMSVSDESVMTESSRPPSIASAPLPIVNEPSDDPVTPPLSPEVDCHLPIIPERHLPSFSRPTRRDADLSYSHETIRGPKAEDVDATPRATMRGYPQERAEAGPSSNQRTPLPAAVLPFSKDENANVDPVLVDRLAGEIARRMREDKLMTNACSGFWSRQHEDSPPPAYGH