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mdfA

Gene
mdfA
Protein
Multidrug transporter MdfA
Organism
Escherichia coli O157:H7
Length
410 amino acids
Function
Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs (By similarity).
Similarity
Belongs to the major facilitator superfamily. MdfA family.
Mass
44.321 kDa
Sequence
MQNKLASGARLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASDMSKGTVSAAMGMLQMLIFTVGIEISKHAWLNGGNGLFNLFNLVNGILWLSLMVIFLKDKQMGNSHEG

Gene
mdfA
Protein
Multidrug transporter MdfA
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Length
410 amino acids
Function
Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs (By similarity).
Similarity
Belongs to the major facilitator superfamily. MdfA family.
Mass
44.321 kDa
Sequence
MQNKLASGARLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASDMSKGTVSAAMGMLQMLIFTVGIEISKHAWLNGGNGLFNLFNLVNGILWLSLMVIFLKDKQMGNSHEG

Gene
mdfA
Protein
Multidrug transporter MdfA
Organism
Escherichia coli (strain K12)
Length
410 amino acids
Function
Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs. Confers resistance to a diverse group of cationic or zwitterionic lipophilic compounds such as ethidium bromide, tetraphenylphosphonium, rhodamine, daunomycin, benzalkonium, rifampicin, tetracycline, puromycin, and to chemically unrelated, clinically important antibiotics such as chloramphenicol, erythromycin, and certain aminoglycosides and fluoroquinolones. Overexpression results in isopropyl-beta-D-thiogalactopyranoside (IPTG) exclusion and spectinomycin sensitivity. Transport of neutral substrates is electrogenic, whereas transport of cationic substrates is electroneutral. In addition to its role in multidrug resistance, confers extreme alkaline pH resistance, allowing the growth under conditions that are close to those used normally by alkaliphiles. This activity requires Na(+) or K(+).
Similarity
Belongs to the major facilitator superfamily. MdfA family.
Mass
44.321 kDa
Sequence
MQNKLASGARLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASDMSKGTVSAAMGMLQMLIFTVGIEISKHAWLNGGNGLFNLFNLVNGILWLSLMVIFLKDKQMGNSHEG

Gene
mdfA
Protein
Multidrug transporter MdfA
Organism
Edwardsiella ictaluri (strain 93-146)
Length
410 amino acids
Function
Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs (By similarity).
Similarity
Belongs to the major facilitator superfamily. MdfA family.
Mass
44.526 kDa
Sequence
MQNHLSSTRRLGRRALLFPLCLVLYEFATYIGNDMIQPGMLSVVQTFGVDESWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLIGTLYFAATCLAILLTNSIEQFTLMRFLQGISLCFIGAVGYAAIQESFEESVCIKITALMANVALIAPLLGPLAGAAWVHLFPWEGMFILFAALSLLAFLGLYKAMPETATRRGEKLSLSALGRDYTLVLKNRRFLCGSLACGFASLPLLAWIAQSPVIIISGEGLSSYDYGMLQVPIFGMLILGNLTLARLSGRRPVRRLIQLGAWPMVGGLAIAAASTLYSAHAYLWMTAGLSLYAFGIGLANAGLYRLTLFSSTMSKGTVSAAMGMISMFIYTLGIEVGKYAWLLGGNGAFNLFNLISGLLWLALIARMLRDQLVGRMAGR

Gene
mdfA
Protein
Multidrug transporter MdfA
Organism
Edwardsiella tarda (strain EIB202)
Length
410 amino acids
Function
Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs (By similarity).
Similarity
Belongs to the major facilitator superfamily. MdfA family.
Mass
44.39 kDa
Sequence
MQNRLSSTRRLGRRALLFPLCLVLYEFATYIGNDMIQPGMLSVVQTFGVDESWVPTSMTAYLAGGMFLQWLLGPISDRIGRRPVMLTGTLYFAVTCLAILLTNSIEQFTLMRFLQGISLCFIGAVGYAAIQESFEESVCIKITALMANVALIAPLLGPLAGAAWVHLFPWEGMFILFAALSLLAFLGLYKAMPETATRRGETLSLSALGHDYALVLKNKRFLGGALACGFASLPLLAWIAQSPVIIISGEGLSSYDYGMLQVPIFGMLILGNFTLARLSGRRPVRRLIQLGAWPMVGGLAIAAVSTLYSAHAYLWMTAGLSLYAFGIGLANAGLYRLTLFSSTMSKGTVSAAMGMISMFIYTLGIEVGKHAWLLGGNGAFNLFNLISGLLWLALVALMLRDKRVGGTTER

Gene
mdfA
Protein
Multidrug transporter MdfA
Organism
Edwardsiella tarda (strain FL6-60)
Length
410 amino acids
Function
Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs (By similarity).
Similarity
Belongs to the major facilitator superfamily. MdfA family.
Mass
44.39 kDa
Sequence
MQNRLSSTRRLGRRALLFPLCLVLYEFATYIGNDMIQPGMLSVVQTFGVDESWVPTSMTAYLAGGMFLQWLLGPISDRIGRRPVMLTGTLYFAVTCLAILLTNSIEQFTLMRFLQGISLCFIGAVGYAAIQESFEESVCIKITALMANVALIAPLLGPLAGAAWVHLFPWEGMFILFAALSLLAFLGLYKAMPETATRRGETLSLSALGHDYALVLKNKRFLGGALACGFASLPLLAWIAQSPVIIISGEGLSSYDYGMLQVPIFGMLILGNFTLARLSGRRPVRRLIQLGAWPMVGGLAIAAVSTLYSAHAYLWMTAGLSLYAFGIGLANAGLYRLTLFSSTMSKGTVSAAMGMISMFIYTLGIEVGKHAWLLGGNGAFNLFNLISGLLWLALVALMLRDKRVGGTTER

Gene
mdfA
Protein
Multidrug transporter MdfA
Organism
Shigella boydii serotype 4 (strain Sb227)
Length
410 amino acids
Function
Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs (By similarity).
Similarity
Belongs to the major facilitator superfamily. MdfA family.
Mass
44.307 kDa
Sequence
MQNKLASGARLGRQALLFPLCLVLYEFSTYIGADMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIITCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASDMSKGTVSAAMGMLQMLIFTVGIEISKHAWLNGGNGQFNLFNLVNGILWLSLMVIFLKDKQMGNSHEG

Gene
mdfA
Protein
Multidrug transporter MdfA
Organism
Yersinia pestis (strain D182038)
Length
409 amino acids
Function
Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs (By similarity).
Similarity
Belongs to the major facilitator superfamily. MdfA family.
Mass
44.065 kDa
Sequence
MQTSFSPATRLGRRALLFPLCLVLFEFAAYIANDMIQPGMLAVVAEFNASVEWVPTSMTAYLAGGMFLQWLLGPLSDRRGRRPVMLAGVAFFVVTCLAILLVNSIEQFIAMRFLQGIGLCFIGAVGYATIQESFEEAVCIKITALMANVALIAPLLGPLAGAALIHVAPWQTMFVLFAVLGAISFAGLWRAMPETASLKGEKLSVANMWRDYKQVLANRRFLCGSLALGFASLPLLAWIAQSPVILISGEQLSTFEYGILQVPIFGALIIGNLTLARLSGKTSIPQLIRYGAGPMIVGLMIAAGSTLYSSHAYLWMTAGLSLYAFGIGLANAGLVRLTLFASDISKGTVSAAMGMISMMIFTLGIELAKVAYLWGDSRGFNLFNLMSGLLWLGLVMVFIRRQPEAVATE

Gene
mdfA
Protein
Multidrug transporter MdfA
Organism
Yersinia pestis (strain D106004)
Length
409 amino acids
Function
Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs (By similarity).
Similarity
Belongs to the major facilitator superfamily. MdfA family.
Mass
44.065 kDa
Sequence
MQTSFSPATRLGRRALLFPLCLVLFEFAAYIANDMIQPGMLAVVAEFNASVEWVPTSMTAYLAGGMFLQWLLGPLSDRRGRRPVMLAGVAFFVVTCLAILLVNSIEQFIAMRFLQGIGLCFIGAVGYATIQESFEEAVCIKITALMANVALIAPLLGPLAGAALIHVAPWQTMFVLFAVLGAISFAGLWRAMPETASLKGEKLSVANMWRDYKQVLANRRFLCGSLALGFASLPLLAWIAQSPVILISGEQLSTFEYGILQVPIFGALIIGNLTLARLSGKTSIPQLIRYGAGPMIVGLMIAAGSTLYSSHAYLWMTAGLSLYAFGIGLANAGLVRLTLFASDISKGTVSAAMGMISMMIFTLGIELAKVAYLWGDSRGFNLFNLMSGLLWLGLVMVFIRRQPEAVATE

Gene
mdfA
Protein
Multidrug transporter MdfA
Organism
Yersinia pestis bv. Antiqua (strain Angola)
Length
409 amino acids
Function
Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs (By similarity).
Similarity
Belongs to the major facilitator superfamily. MdfA family.
Mass
44.065 kDa
Sequence
MQTSFSPATRLGRRALLFPLCLVLFEFAAYIANDMIQPGMLAVVAEFNASVEWVPTSMTAYLAGGMFLQWLLGPLSDRRGRRPVMLAGVAFFVVTCLAILLVNSIEQFIAMRFLQGIGLCFIGAVGYATIQESFEEAVCIKITALMANVALIAPLLGPLAGAALIHVAPWQTMFVLFAVLGAISFAGLWRAMPETASLKGEKLSVANMWRDYKQVLANRRFLCGSLALGFASLPLLAWIAQSPVILISGEQLSTFEYGILQVPIFGALIIGNLTLARLSGKTSIPQLIRYGAGPMIVGLMIAAGSTLYSSHAYLWMTAGLSLYAFGIGLANAGLVRLTLFASDISKGTVSAAMGMISMMIFTLGIELAKVAYLWGDSRGFNLFNLMSGLLWLGLVMVFIRRQPEAVATE

Gene
mdfA
Protein
Multidrug transporter MdfA
Organism
Yersinia pestis (strain Z176003)
Length
409 amino acids
Function
Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs (By similarity).
Similarity
Belongs to the major facilitator superfamily. MdfA family.
Mass
44.065 kDa
Sequence
MQTSFSPATRLGRRALLFPLCLVLFEFAAYIANDMIQPGMLAVVAEFNASVEWVPTSMTAYLAGGMFLQWLLGPLSDRRGRRPVMLAGVAFFVVTCLAILLVNSIEQFIAMRFLQGIGLCFIGAVGYATIQESFEEAVCIKITALMANVALIAPLLGPLAGAALIHVAPWQTMFVLFAVLGAISFAGLWRAMPETASLKGEKLSVANMWRDYKQVLANRRFLCGSLALGFASLPLLAWIAQSPVILISGEQLSTFEYGILQVPIFGALIIGNLTLARLSGKTSIPQLIRYGAGPMIVGLMIAAGSTLYSSHAYLWMTAGLSLYAFGIGLANAGLVRLTLFASDISKGTVSAAMGMISMMIFTLGIELAKVAYLWGDSRGFNLFNLMSGLLWLGLVMVFIRRQPEAVATE