mct

2-methylfumaryl-CoA isomerase

409 amino acids

Involved in the glyoxylate assimilation cycle used to regenerate acetyl-CoA and produce pyruvate as universal precursor for biosynthesis. This reaction involves an intramolecular CoA transferase that catalyzes the reversible transfer of the CoA moiety from the C1-carboxyl group of mesaconyl-CoA to the C4-carboxyl group. It does not require free mesaconate as CoA acceptor.

Belongs to the CoA-transferase III family. Mesaconyl-CoA isomerase subfamily.

44.813 kDa

MKGILHGLRVVEGSAFVAAPLGGMTLAQLGADVIRFDPIGGGLDYKRWPVTLDGKHSLFWAGLNKGKRSIAIDIRHPRGQELLTQLICAPGEHAGLFITNFPARGWLSYDELKRHRADLIMVNLVGRRDGGSEVDYTVNPQLGLPFMTGPVTTPDVVNHVLPAWDIVTGQMIALGLLAAERHRRLTGEGQLVKIALKDVGLAMIGHLGMIAEVMINDTDRPRQGNYLYGAFGRDFETLDGKRVMVVGLTDLQWKALGKATGLTDAFNALGARLGLNMDEEGDRFRARHEIAALLEPWFHARTLAEVRRIFEQHRVTWAPYRTVREAIAQDPDCSTDNPMFAMVEQPGIGSYLMPGSPLDFTAVPRLPVQPAPRLGEHTDEILLEVLGLSEAEVGRLHDEGIVAGPDRAA

mct

Succinyl-CoA:mesaconate CoA-transferase

396 amino acids

Involved in the methylaspartate cycle. Catalyzes the transfer of the CoA moiety from succinyl-CoA to mesaconate to generate mesaconyl-CoA (2-methylfumaryl-CoA) and succinate.

Belongs to the CoA-transferase III family.

42.956 kDa

MGALDDLRVLDLTQVLAGPYCTMLLADMGADVVKVERPGGDLIRSNPPFVSDGDEEAYGGYFQSVNRGKRSLELNLGTDEDREAFLSLVERADVVVENFKAGTMEKFDCGYETLREHNPDLIYSSIRGFGDPRTGETHRQGQPSFDLIAQALGGVMEITGQSDGPPTKVGPGVGDLFTAVLNAVGILAAVHHRERTGEGQYVDTAMYDSMVSLCERTVYQYSCDGESPTRQGNSHPTLFPYDSFEAADGHVVIAAFADGHWEALCEAMERPDLAAEYPDAGSRIANRESLRAEIAEWTTAIDSETLLDLLEGRVPAAPVQNTADIFDDPHIHDREMLAEVDQPGADDQMTIAGSPIKMTETMPSPGGRAPLLDEHKTELLDEAGVDTGTNRVESDD