mcr1

Probable phosphatidylethanolamine transferase Mcr-1

541 amino acids

Confers resistance to polymyxin-type antibiotics; expression of the Mcr-1 protein in E.coli increases colistin and polymyxin B minimal inhibitory concentration (MIC) from 0.5 mg/ml to 2.0 mg/ml. The pHNSHP45 plasmid can transfer efficiently (0.1 to 0.001) to other E.coli strains by conjugation and increases polymxin MIC by 8- to 16-fold; it may not require selective pressure to be maintained in the cell. When transformed into K.pneumoniae or P.aeruginosa it also increases polymxin MIC 8- to 16-fold. In a murine (BALB/c mice) thigh infection study using an mcr1-encoding plasmid isolated from a human patient, the plasmid confers in vivo protection against colistin (PubMed:26603172).

Belongs to the phosphoethanolamine transferase family.

60.124 kDa

MMQHTSVWYRRSVSPFVLVASVAVFLTATANLTFFDKISQTYPIADNLGFVLTIAVVLFGAMLLITTLLSSYRYVLKPVLILLLIMGAVTSYFTDTYGTVYDTTMLQNALQTDQAETKDLLNAAFIMRIIGLGVLPSLLVAFVKVDYPTWGKGLMRRLGLIVASLALILLPVVAFSSHYASFFRVHKPLRSYVNPIMPIYSVGKLASIEYKKASAPKDTIYHAKDAVQATKPDMRKPRLVVFVVGETARADHVSFNGYERDTFPQLAKIDGVTNFSNVTSCGTSTAYSVPCMFSYLGADEYDVDTAKYQENVLDTLDRLGVSILWRDNNSDSKGVMDKLPKAQFADYKSATNNAICNTNPYNECRDVGMLVGLDDFVAANNGKDMLIMLHQMGNHGPAYFKRYDEKFAKFTPVCEGNELAKCEHQSLINAYDNALLATDDFIAQSIQWLQTHSNAYDVSMLYVSDHGESLGENGVYLHGMPNAFAPKEQRSVPAFFWTDKQTGITPMATDTVLTHDAITPTLLKLFDVTADKVKDRTAFIR

MCR1

NADH-cytochrome b5 reductase 2

350 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

37.613 kDa

MFIRPVLSSSLGHAARSSLRSQAPAVRQYATEAGKSSGGSNLPLVLALGGVAGIGAWYGLGGFDDPKKVSNKIQEKGKEAVDQAKGAVEGGALNKDQFVEFTLKEIKPYNHDSATLIFELPEGKKPGMGVASAVVVKAVGDGLKDDQGKDVIRPYTPITSPDTVGHMDFLVKKYPGGKMTTYMHSMKPGDKLGIKGPIAKFAYKANEFESIGMIAGGSGITPMYQVIQDIASNPSDKTKVTLIYSNKTEQDILLREQFDQLAKKDDRFTIIYGLDKLPKGFNGFEGYVTEDLVKKHLPQPELADKAKIFVCGPPPQVEAISGKKGPKGSQGELKGLLAKLGYQADQVYKF

MCR1

NADH-cytochrome b5 reductase 2

350 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

37.613 kDa

MFIRPVLSSSLGHAARSSLRSQAPAVRQYATEAGKSSGGSNLPLVLALGGVAGIGAWYGLGGFDDPKKVSNKIQEKGKEAVDQAKGAVEGGALNKDQFVEFTLKEIKPYNHDSATLIFELPEGKKPGMGVASAVVVKAVGDGLKDDQGKDVIRPYTPITSPDTVGHMDFLVKKYPGGKMTTYMHSMKPGDKLGIKGPIAKFAYKANEFESIGMIAGGSGITPMYQVIQDIASNPSDKTKVTLIYSNKTEQDILLREQFDQLAKKDDRFTIIYGLDKLPKGFNGFEGYVTEDLVKKHLPQPELADKAKIFVCGPPPQVEAISGKKGPKGSQGELKGLLAKLGYQADQVYKF

MCR1

NADH-cytochrome b5 reductase 2

348 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

38.131 kDa

MSLFVASRSAFRAAAPLKRQFQIRRYATEPPSADAKKGNNTLLYGAAAAAVAGAGYYFLGGTPAAKKAEEKVKDASSAAAGKLSTSEVKQALTGGEQGWVSLKLEEVEIVNHNSKRLRFRLPEDDMVSGVHVASAILTKFKPVDAEKPVIRPYTPTNDEDARGYLDLLVKKYPNGPMSTHLHDMVPGQRLDVKGPLPKYPWTANKHGHIALVAGGTGITPMFQLCRAIFNNPDDQTKVTLVFGNVREDDILLKKELAALENNNPRRFRAFYVLDDPPKHWTGGKGFITKDLLKTVLPEPKDENIKVFVCGPPGMMDAISGNKKSPKDQGELKGILKELGYSPEQVYKF

mcr1

NADH-cytochrome b5 reductase 2

346 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

37.692 kDa

MFARQAIRAAQPLKSQYRRYATESTSGGGSNAALYAGLAAAAGAGAYYFLNQGDNAAKVKDAAKDAEAKAKEAVGQGKSKVEGAVGKAAFTGGDQGFISLKLDSVENINHNTKKFRFELPESDQVSGLQVASALLTKFKGPEMQKPAIRPYTPTSDESEQGFIDLLVKKYPNGVMSEHMHDMVPGQRLDFKGPIPKYPWSANKHDHIALIAGGTGITPMYQLARAIFNNPADKTKVTLVFANVTEEDILLKREFEDLENTYPQRFRAFYVLDNPPKSWSGGKGFVNKELLKTVLPEPKTENVKVFVCGPPGMYKAISGPKVSPSDQGELAGILKELGYSKEQVYKF

mcr1

NADH-cytochrome b5 reductase 2

345 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

37.819 kDa

MFARQTLRAAQPFRSQYRRYATESSSSGSNTALYTGVAAAVAGAGYYFMSQGDNAAKVKDAAKDAEAKAKEALGQGQAKVEGAVGKAAFTGGDQGFISLKLDSVELVNHNTKKFRFELPESDQVSGLHVTSALITKYKGPEMQKPAIRPYTPTSDEGEKGFIDLLVKKYPNGVMSEHMHEMVPGQRLDFKGPIPKYAWSANKHDHIALIAGGTGITPMYQLARAIFNNPADKTKVTLVFANVTEEDILLKREFEDLENTYPQRFRAFYVLDNPPKSWKGGKGFINKELLKTVLPEPKSENIKLFVCGPPGMYKAISGGKVSPSDQGELAGILKELGYSKDQVYKF

mcr1

NADH-cytochrome b5 reductase 2

345 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

37.819 kDa

MFARQTLRAAQPFRSQYRRYATESSSSGSNTALYTGVAAAVAGAGYYFMSQGDNAAKVKDAAKDAEAKAKEALGQGQAKVEGAVGKAAFTGGDQGFISLKLDSVELVNHNTKKFRFELPESDQVSGLHVTSALITKYKGPEMQKPAIRPYTPTSDEGEKGFIDLLVKKYPNGVMSEHMHEMVPGQRLDFKGPIPKYAWSANKHDHIALIAGGTGITPMYQLARAIFNNPADKTKVTLVFANVTEEDILLKREFEDLENTYPQRFRAFYVLDNPPKSWKGGKGFINKELLKTVLPEPKSENIKLFVCGPPGMYKAISGGKVSPSDQGELAGILKELGYSKDQVYKF

MCR1

NADH-cytochrome b5 reductase 2

336 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

37.024 kDa

MFARQVIRPARQLQQHVRRYASEAPQSGGSSNGALYVGIGAAGLAGAYIYMRGGKPAAPLSEEANKVAAKVGGASKKAFTGGDQGFISLLLDKSEVVNHNTKKLTFKLPEPDMESGLPVTSAVITKYKGPEMEKPVIRPYTPVSDVDQQGTVDFIVKKYEKGPMSSHMHNMEPGQRLDIKGPIPKYPWSPNKHEHIALIAGGTGITPMWQTARAIFKNPEDKTKVTLVFGNISEEDILLKKEWEHLENTYPQRFRAFYVLDNPPESWQGGKGFITKELLKTVLPEPKEGEKVKIFVCGPPGMYKAISGGKKSPSDQGELDGYLKELGYSKDQVYKF

MCR1

NADH-cytochrome b5 reductase 2

336 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

37.024 kDa

MFARQVIRPARQLQQHVRRYASEAPQSGGSSNGALYVGIGAAGLAGAYIYMRGGKPAAPLSEEANKVAAKVGGASKKAFTGGDQGFISLLLDKSEVVNHNTKKLTFKLPEPDMESGLPVTSAVITKYKGPEMEKPVIRPYTPVSDVDQQGTVDFIVKKYEKGPMSSHMHNMEPGQRLDIKGPIPKYPWSPNKHEHIALIAGGTGITPMWQTARAIFKNPEDKTKVTLVFGNISEEDILLKKEWEHLENTYPQRFRAFYVLDNPPESWQGGKGFITKELLKTVLPEPKEGEKVKIFVCGPPGMYKAISGGKKSPSDQGELDGYLKELGYSKDQVYKF

MCR1

NADH-cytochrome b5 reductase 2

331 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

36.574 kDa

MFARPAIRACQSLKQPVRRYTNTPPPQSGNANNSRVGILIASAVGMAGFGTYFMFGQGTTPAAGVKALGAEPKKALEMEKGFVSLQLDDVEVVNHNTKRLRFKLPEDDMVSGLHVASALLTKFKPEGAEKPVLRPYTPISDEDQKGYLDLIVKKYEGGPMSTHIHELVPGQKLDFKGPLPKYEWSANKHPHVAMIAGGTGITPMYQIMRAIFKNPADKTKVTLVVGNITEEDILLKKQLAELENTYPQRFRAFYVLDNPPKDWAGTKGYITKDLLKTVLPEPKEENIKVFVCGPPGMMKAISGNKVSPKDQGEVSGILKELGYKQDQIYKF

MCR1

NADH-cytochrome b5 reductase 2

325 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

36.509 kDa

MFARFTFRTCRPAGQAIRKYASEASPKPSSNVPLYGGLALAAGGAYYYWQRQQSPQALEAALKERSKVFIGGDQGWVDLKLAGIETLSHNVKRFRFEFPDSESVSGLHIASALLTKYKGPKDEKPTIRPYTPVSEEEQPGYLDLVVKQYPNGPMSTHLHNMAVGQQLSFKGPIPKYPWEQNKHDHICMIAGGTGITPMYQIIRKIFNNPNDKTKVTLVFGNITEEDILLKKELDILENTYPRRFRAFYLLDKPPAGWTQGTGYVTKELLKTVLPEPKTENIKIFVCGPPGMYKAVSGPKNSPKDQGELTGLLKELGYDKDQVYKF

MCR1

NADH-cytochrome b5 reductase 2

324 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

36.615 kDa

MFARYTFRCSQPLAQSVRKYSSEAPAKSSRIPLIGGITLAAGAGYYYYWQTTSAKSEPKERSTVFKGGDQGWIGLKLAHIDNVNHNVKKLRFEFEDPESVSGLHIASALLTKYKGLTDEKPTIRPYTPVSDEGMWASLGYLDLLVKRYPNGPMSNHLHNMAVGQRLDFKGPLPKYPWEPSKHDHICLIAGGTGITPMYQLVRKIFSNPEDKTKVTLVFANVTEEDILLRKEFEHLENTYPRRFRAFYTLDKPPKNWAQGTGFITKDLLKTVLPEPKTENIKIFVCGPPAMYKAISGQKVSPKDQGELSGILKELGYSKEQVYKF

mcr1

NADH-cytochrome b5 reductase 2

323 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

36.231 kDa

MFARQSLRFAQPLKQGFRKYSTEAPSKGKSSLAPIYVAVGLTGLGVGLYRYNSASAEAPPAERPKVFTGGDQGWVDLKLAQIENLSPNTKRLRFEFPDKEAVSGLHVASALLTKFKPHGAEKPVIRPYTPVSDEEQPGYLDLVVKVYPNGPMSEHLHSMNVDQRLEFKGPIPKYPWEANKHKHICLIAGGTGITPMYQLARKIFKDPEDQTKVTLVFGNVREEDILLKKELQELENTYPRRFRAFYVLDHPPKEWTGGKGYITKELLKTVLPEPKEENIKIFVCGPPGMYKSISGPKVSPKDQGELTGILAELGYSKDQVFKF

mcr1

NADH-cytochrome b5 reductase 2

323 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

36.231 kDa

MFARQSLRFAQPLKQGFRKYSTEAPSKGKSSLAPIYVAVGLTGLGVGLYRYNSASAEAPPAERPKVFTGGDQGWVDLKLAQIENLSPNTKRLRFEFPDKEAVSGLHVASALLTKFKPHGAEKPVIRPYTPVSDEEQPGYLDLVVKVYPNGPMSEHLHSMNVDQRLEFKGPIPKYPWEANKHKHICLIAGGTGITPMYQLARKIFKDPEDQTKVTLVFGNVREEDILLKKELQELENTYPRRFRAFYVLDHPPKEWTGGKGYITKELLKTVLPEPKEENIKIFVCGPPGMYKSISGPKVSPKDQGELTGILAELGYSKDQVFKF

mcr1

NADH-cytochrome b5 reductase 2

323 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

36.174 kDa

MFARQSLRVAQPLKQGFRKYSTEAPSKGKSSLAPIYLGVGLIGLGVGLYRYNSASAEAPPAERPKVFTGGDQGWVDLKLAQIENLSPNTKRLRFEFPDKEAVSGLHVASALLTKFKPQGAEKPVIRPYTPVSDEEQPGYLDLVVKVYPNGPMSEHLHSMNVDQRLEFKGPIPKYPWEANKHKHICLIAGGTGITPMYQLARKIFKDPEDQTKVTLVFGNVREEDILLKKELEELENTYPRRFRAFYLLDHPPKEWTGGKGYITKELLKTVLPEPKEENIKIFVCGPPGMYKSISGPKVSPTDQGELTGILAELGYSKDQVFKF

mcr1

NADH-cytochrome b5 reductase 2

323 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

36.322 kDa

MFARQTFRCAQPLRQSFRKYSTEAPKAKSLAPIYTAVGLTGLSVGLYRYYYGAGATAEAPVERAKVFTGGDQGWVDLKLSEIEVLSHNTKRLRFEFEDKEAVSGVTIASALLTKFKPVGAEKAVLRPYTPTSDEDQPGYLDLVVKVYPNGPMSEHLHSMNVDQRLSFKGPLPKYQWETNKHEHIALIAGGTGITPMYQLIRQIFKNPDDKTKVTLVYGNVTEDDILLKKELQDLENTYPQRFKAFYLLDKPPKEWTGGKGYINKELLKTVLPEPKEENQKIFVCGPPGLYNAVSGNKVSPKDQGELSGILKELGYNKDQVYKF

mcr1

NADH-cytochrome b5 reductase 2

322 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

36.04 kDa

MFARQPLRFAQPLKQGFRKYSTEAPAKGKSSLAPIYISVGLAGLGVGLYRYSTASAETPVVDRPKVFTGGEQGWVDLKLSEIENLSHNTKRLRFEFADKEAVSGLQVASALLTKFKPAEGKPVIRPYTPVSDEDQPGYLDLVVKVYPNGPMSEHLHSMNVDQRLEFKGPIPKYPWETNKHKHICLIAGGTGITPMYQLARQIFKNPEDQTKVTLVFGNVSEEDILLKKELQELENTHPRRFKAFYVLDNPPKEWTGGKGYVTKELLKTVLPEPKEEDIKIFVCGPPGMYKAISGPKVSPKDQGELTGLLAELGYNKDQVYKF

mcr1

NADH-cytochrome b5 reductase 2

322 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

36.09 kDa

MFARQAFRCAQPLKQGFRKYSTEAPKGKSSLAPIYAAVGITGVGVGLYRYNSATAEAPAAVDRPKVFKGGDQGWFDLKLSEIEVLNHNTKRLRFEFEDKEALSGLQVASALLTKFKPADAKAVIRPYTPTSDEETPGYIDLVVKVYPNGPMSEHLHSMNVGQRLDFKGPIVKYPWETNKHNHICLIAGGTGITPMYQLAREIFKNPEDQTKVTLVFGNVKEEDILLKKEFEELENTYPRRFRAFYVLDNPPKEWTGGKGYISKELLKTVLPEPKEENIKIFVCGPPGMYKAISGTKNSPTDQGELSGILKELGYSKEQVFKF

mcr1

NADH-cytochrome b5 reductase 2

322 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

36.073 kDa

MFSRYAFRCAQPLRQSARQYSTEAPKSKSLAPVYVAVGLAGLGVGLYRYQSGAATAEAPAERPKVFTGGDQGWVNLKLSDIEILSHNTKRLRFEFPDKEAVSGLHIASALLTKYSPPDGSKPVIRPYTPTSDEDQPGYLELVVKRYPNGPMSEHLHNMNVDQRLDFKGPLPKYPWEANKHKHICLVAGGTGITPMYQLAREIFKNPEDKTKVTLVFGNVSEEDILLKREFEDLENTYPQRFRAFYVLDNPPEGWTGGKGYITKELLKTVLPEPKEENIKIFVCGPPGMYKAISGPKVSPKDQGELTGILKELGYSKDQVYKF

mcr1

NADH-cytochrome b5 reductase 2

319 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

35.834 kDa

MFARQTFRYAQPLKQSFRKYSTEAPKGKSLAPVYLTVGLAGLGVGLYRYNSATAEAPAERAKVFTGGDQGWVDLKLSEIEVLNHNTKRFRFEFEDKEAVSGLNVASALLTKFKPEGGKAVLRPYTPVSDESQPGFLDLVVKVYPNGPMSEHLHSMNVDQRLEFKGPLPKYPWEANKHQHICLIAGGTGITPMYQLARHIFKNPEDKTKVTLVYGNVSEQDILLKKELEELENTYPQRFKAFYVLDNPPKEWTGGKGYISKELLKTVLPEPKEENIKIFVCGPPGLYKAISGNKVSPKDQGELTGILKELGYSQEQVFKF

MCR1

NADH-cytochrome b5 reductase 2

306 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

33.771 kDa

MLSRITRSSKALNFALGTTAVAAAGYLYAQSRGNLSTSLNKGDVTGQAAAQTFTGDGQWHALKIAKIEQVSHDTRRFTFALPSQDHVTGLTTASALLAKYVTPKGSNVIRPYTPVSDNMARGMFQLVIKHYDGGKFTTHLFGLKENDTVEFKGPIQKWRWDPNMFDSIVLMGAGTGITPLFQMMHHIAENPTDNTKVHLLYGNKTPQDILLRKELEELASKYPDQVKVTYFVDKPEGDYKGEKGFITKDFLKQNLPTPGSNSHIFVCGPPPFMDAFSGNKVSPSDQGQVTGVLSELGYTKDHVYKF

MCR1

NADH-cytochrome b5 reductase 2

302 amino acids

The outer membrane form may mediate the reduction of outer membrane cytochrome b5, and the soluble inter-membrane space form may transfer electrons from external NADH to cytochrome c, thereby mediating an antimycin-insensitive, energy-coupled oxidation of external NADH by yeast mitochondria. Involved in the reduction of D-erythroascorbyl free radicals (By similarity).

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

34.108 kDa

MFSRLSRSHSKALPIALGTVAIAAATAFYFANRNQHSFVFNESNKVFKGDDKWIDLPISKIEEESHDTRRFTFKLPTEDSEMGLVLASALFAKFVTPKGSNVVRPYTPVSDLSQKGHFQLVVKHYEGGKMTSHLFGLKPNDTVSFKGPIMKWKWQPNQFKSITLLGAGTGINPLYQLAHHIVENPNDKTKVNLLYGNKTPQDILLRKELDALKEKYPDKFNVTYFVDDKQDDQDFDGEIGFISKDFIQEHVPGPKESTHLFVCGPPPFMNAYSGEKKSPKDQGELIGILNNLGYSKDQVFKF

MCR1

NADH-cytochrome b5 reductase 2

302 amino acids

The outer membrane form may mediate the reduction of outer membrane cytochrome b5, and the soluble inter-membrane space form may transfer electrons from external NADH to cytochrome c, thereby mediating an antimycin-insensitive, energy-coupled oxidation of external NADH by yeast mitochondria. Involved in the reduction of D-erythroascorbyl free radicals.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

34.138 kDa

MFSRLSRSHSKALPIALGTVAIAAATAFYFANRNQHSFVFNESNKVFKGDDKWIDLPISKIEEESHDTRRFTFKLPTEDSEMGLVLASALFAKFVTPKGSNVVRPYTPVSDLSQKGHFQLVVKHYEGGKMTSHLFGLKPNDTVSFKGPIMKWKWQPNQFKSITLLGAGTGINPLYQLAHHIVENPNDKTKVNLLYGNKTPQDILLRKELDALKEKYPDKFNVTYFVDDKQDDQDFDGEISFISKDFIQEHVPGPKESTHLFVCGPPPFMNAYSGEKKSPKDQGELIGILNNLGYSKDQVFKF

MCR1

NADH-cytochrome b5 reductase 2

302 amino acids

The outer membrane form may mediate the reduction of outer membrane cytochrome b5, and the soluble inter-membrane space form may transfer electrons from external NADH to cytochrome c, thereby mediating an antimycin-insensitive, energy-coupled oxidation of external NADH by yeast mitochondria. Involved in the reduction of D-erythroascorbyl free radicals (By similarity).

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

34.108 kDa

MFSRLSRSHSKALPIALGTVAIAAATAFYFANRNQHSFVFNESNKVFKGDDKWIDLPISKIEEESHDTRRFTFKLPTEDSEMGLVLASALFAKFVTPKGSNVVRPYTPVSDLSQKGHFQLVVKHYEGGKMTSHLFGLKPNDTVSFKGPIMKWKWQPNQFKSITLLGAGTGINPLYQLAHHIVENPNDKTKVNLLYGNKTPQDILLRKELDALKEKYPDKFNVTYFVDDKQDDQDFDGEIGFISKDFIQEHVPGPKESTHLFVCGPPPFMNAYSGEKKSPKDQGELIGILNNLGYSKDQVFKF

MCR1

NADH-cytochrome b5 reductase 2

302 amino acids

The outer membrane form may mediate the reduction of outer membrane cytochrome b5, and the soluble inter-membrane space form may transfer electrons from external NADH to cytochrome c, thereby mediating an antimycin-insensitive, energy-coupled oxidation of external NADH by yeast mitochondria. Involved in the reduction of D-erythroascorbyl free radicals.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

34.138 kDa

MFSRLSRSHSKALPIALGTVAIAAATAFYFANRNQHSFVFNESNKVFKGDDKWIDLPISKIEEESHDTRRFTFKLPTEDSEMGLVLASALFAKFVTPKGSNVVRPYTPVSDLSQKGHFQLVVKHYEGGKMTSHLFGLKPNDTVSFKGPIMKWKWQPNQFKSITLLGAGTGINPLYQLAHHIVENPNDKTKVNLLYGNKTPQDILLRKELDALKEKYPDKFNVTYFVDDKQDDQDFDGEISFISKDFIQEHVPGPKESTHLFVCGPPPFMNAYSGEKKSPKDQGELIGILNNLGYSKDQVFKF

MCR1

NADH-cytochrome b5 reductase 2

301 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

33.46 kDa

MLTHHLSKLATPKFLVPFAGATALSIGLALQYSTSNNYIANETGKTFTDSNEWVDLKLSKSIDLTHNTKHLVFKLKDENDVSGLITASCLLTKFVTPKGNNVIRPYTPVSDVNQSGEIDFVIKKYDGGKMSSHIFDLKEGETLSFKGPIVKWKWEPNQFKSIALIGGGTGITPLYQLLHQITSNPKDNTKVNLIYGNLTPEDILLKKEIDAIASKHKDQVKVHYFVDKADEKKWEGQIGFITKEFLQKELEKPGSDFKVFVCGPPGLYKAISGPKVSPTDQGELTGALKDLGFEKEHVFKF

MCR1

NADH-cytochrome b5 reductase 2

300 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

33.537 kDa

MSVSRLFSNPKFVYPLVGATIGSIGLAYYSTQAQFYIANETGKTFTGGDQWIDLKLKKSEDLTHNTKHLTFELLNPDDVSGLITASMLMTKYVTPKGNNVIRPYTPVSDPDQKGTLDFVIKRYENGKMSNHIHNLKEGETLSFKGPVVKWKWEPNQFKSIALIGGGTGITPLYQLLREITSNPEDKTKVSLIYGNTSPEDVLIKDRIDDIAAKHKDQVKVTYFVDENKATKDWEGEVGFITKEFLEKELDKPSPDFKIFVCGPPGLYKAISGVKVSPTDQGEVEGALKDLGFSKEHVFKF

MCR1

NADH-cytochrome b5 reductase 2

299 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

33.153 kDa

MSFTRQLTKNLTSFKVLAPFAAAVGSVGIAYQYSTSSIMNETGKTFTGNDEWIDLKLAKSWDTTHNTKHFVFELANQDDVSGLINASCLLTKFVTPKGNNVIRPYTPISDVDGKGSIEFVIKKYDGGKMSSHIHDLKPNDTLAFKGPVVKWKWEPNQYKSIALIGGGTGITPLYQLMHEITKNPEDKTKVNLFYGNLTEKDILIKKELDTIAEKHKDQVNVVYFLDKAPENWNGETGYISKEFLQSKLPGPGKDNKVFVCGPPGLYKALSGPKKSPTDQGEVEGALADLGYTKENVFKF

MCR1

NADH-cytochrome b5 reductase 2

298 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

32.581 kDa

MSFSRSFSRLASSKFVLPVAAAAVGLASYSFTSSSFIANEPSKAFKGGDEWIDLKLISSHDLSHDTKHLVFELPNKDDVSGLVTASLLMTKFVTPKGSNVIRPYTPVSDTEQAGTIDFVVKKYEGGKMSSHIHDLKPNDTLSFKGPFVKWKWEPNQFKSIALIGGGTGITPLYQLIHEITKNPADKTQVSLFYGSQTPDDILIKKELDALAAKHKDQVKIVYFVDKADASWKGETGYISKEFLQKNLPAPGPDNKIFVCGPPPLYKAVSGPKVSPTDQGELTGSLAELGFSKENVFKF

MCR1

NADH-cytochrome b5 reductase 2

298 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

32.581 kDa

MSFSRSFSRLASSKFVLPVAAAAVGLASYSFTSSSFIANEPSKAFKGGDEWIDLKLISSHDLSHDTKHLVFELPNKDDVSGLVTASLLMTKFVTPKGSNVIRPYTPVSDTEQAGTIDFVVKKYEGGKMSSHIHDLKPNDTLSFKGPFVKWKWEPNQFKSIALIGGGTGITPLYQLIHEITKNPADKTQVSLFYGSQTPDDILIKKELDALAAKHKDQVKIVYFVDKADASWKGETGYISKEFLQKNLPAPGPDNKIFVCGPPPLYKAVSGPKVSPTDQGELTGSLAELGFSKENVFKF

MCR1

NADH-cytochrome b5 reductase 2

298 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

33.61 kDa

MAFARFARPTQRFLPFAIGAVAVTAGALYLNGWNTIKNENPKVFIGDRKWIDLELEKIIEESHDTKRFFFKLPTDDSVSGLTLASAVLTKFMTPKGNPVIRPYTPVSDLSEKGYIEFVIKHYEGGKMTDHLFQLKPKDTLAFQGPIPKWQWKPNSFDTITLLGGGTGITPLYQLVHHITQNKEDKTKINLFYGSKTPSDILLKKELDDLQKKYPEQLNIQYFVDKDDTGKFDGNKGFITKDFLAKNAPGPKEKTQVFVCGPPPFMDSLSGQKKSPMEQGDLTGALKDLGYSQDQVFKF

MCR1

NADH-cytochrome b5 reductase 2

296 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

33.013 kDa

MFARLSRSNKFLPIALGVGAASIATAIILQRNYSIMNDTSKAFLGDNEWIDLPIIKIEKLSHDTKRFTFALPKKDQVSGLITASCILAKFVTPKGSNVIRPYTPVSDNGTKGKMELVVKHYENGKFTSHLFGLKENDTVSFKGPITKWEWKPNSYDSITLLGAGTGINPLYQLVHHIAENPEDNTKIHLYYGNKTPEDILLKSELDNLQKKYPDQVKITYFVDKAEGNFEGETGFITKDYLSHQAPKPSEKNQVFVCGPPPFMKAYSGPKVSPQDQGELTGILAELGYSKSNVFKF

MCR1

NADH-cytochrome b5 reductase 2

294 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

32.57 kDa

MSLARFTQPRVLLPVVAAATSIGLVYHYSSLSIQNDTAKTFKGGDEWIDLKLKKSWDVSSNTRHFVFELKSPEDVSGLVTASCLMTKFVTAKGNNVIRPYTPVSDVDQKGTIDFVIKKYDGGKMSTHFHGLKEGDTVSFKGPIVKWKWEPNQFQSIALIGGGTGITPLYQLLHEITKNPEDKTKVKLFYGNLTEEDILIKKELDDIAEKHKDQVSITYFVDKASANWKGETGHIDKEFLQSNLPGPSKDSKVFVCGPPGLYKALSGVKVSPTDQGEVTGVLAELGYTKENVYKF

MCR1

NADH-cytochrome b5 reductase 2

294 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

32.57 kDa

MSLARFTQPRVLLPVVAAATSIGLVYHYSSLSIQNDTAKTFKGGDEWIDLKLKKSWDVSSNTRHFVFELKSPEDVSGLVTASCLMTKFVTAKGNNVIRPYTPVSDVDQKGTIDFVIKKYDGGKMSTHFHGLKEGDTVSFKGPIVKWKWEPNQFQSIALIGGGTGITPLYQLLHEITKNPEDKTKVKLFYGNLTEEDILIKKELDDIAEKHKDQVSITYFVDKASANWKGETGHIDKEFLQSNLPGPSKDSKVFVCGPPGLYKALSGVKVSPTDQGEVTGVLAELGYTKENVYKF

MCR1

NADH-cytochrome b5 reductase 2

291 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

31.763 kDa

MLVPWAPIAATSVVAAAASSYYFSNMAISNDAKTATLKGDDQWVDLKLKSSKDLSHNTKALIFELPTPDSTLGLTTASALLTKYVTPKGSNVVRPYTPVSDPDSKGEFELVVKSYPEGKMSKHIHELKEGDTLSFKGPIIKYQWQPNLHKEITLIGAGTGITPLYQLISAINKNPEDKTKVNLFYGNATEGDILLKDEIDAIAKAKPQQFNVHYFLDKPSDNWKGENGFISEEFIKGNSPAADSDNVKVFVCGPPPFYKAISGAKVSPTDQGEVDGALKNLGFNKDQVFKF

MCR1

NADH-cytochrome b5 reductase 2

291 amino acids

May mediate the reduction of outer membrane cytochrome b5.

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

31.763 kDa

MLVPWAPIAATSVVAAAASSYYFSNMAISNDAKTATLKGDDQWVDLKLKSSKDLSHNTKALIFELPTPDSTLGLTTASALLTKYVTPKGSNVVRPYTPVSDPDSKGEFELVVKSYPEGKMSKHIHELKEGDTLSFKGPIIKYQWQPNLHKEITLIGAGTGITPLYQLISAINKNPEDKTKVNLFYGNATEGDILLKDEIDAIAKAKPQQFNVHYFLDKPSDNWKGENGFISEEFIKGNSPAADSDNVKVFVCGPPPFYKAISGAKVSPTDQGEVDGALKNLGFNKDQVFKF