Protein
Endoribonuclease MazF4
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Function
Toxic component of a type II toxin-antitoxin (TA) system. Acts as an endoribonuclease on single-strand RNA, cleaving between the first and second bases in the sequence UCGCU. Neutralized by cognate antitoxin MazE4.
Similarity
Belongs to the PemK/MazF family.
Sequence
MNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDYLGEVTPATMNKINTALATALGLPWP