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mazF4

Gene
mazF4
Protein
Endoribonuclease MazF4
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
105 amino acids
Function
Toxic component of a type II toxin-antitoxin (TA) system. Acts as an endoribonuclease on single-strand RNA, cleaving between the first and second bases in the sequence UCGCU. Neutralized by cognate antitoxin MazE4.
Similarity
Belongs to the PemK/MazF family.
Mass
11.41 kDa
Sequence
MNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDYLGEVTPATMNKINTALATALGLPWP

Gene
mazF4
Protein
Endoribonuclease MazF4
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
105 amino acids
Function
Residues 29-56 inhibit ssDNA cleavage by DNA topoisomerase. This fragment does not have mRNA cleavage activity but it inhibits growth upon overexpression in M.smegmatis.
Similarity
Belongs to the PemK/MazF family.
Mass
11.41 kDa
Sequence
MNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDYLGEVTPATMNKINTALATALGLPWP