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mael2

Gene
mael2
Protein
Protein maelstrom 2
Organism
Drosophila ananassae
Length
468 amino acids
Function
Involved both in the piRNA and miRNA metabolic processes. As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons. As a nuclear component, it is required for proper differentiation in the germline stem cell (GSC) lineage by repressing microRNA-7 (miR-7), thereby acting as an indirect regulator of bag-of-marbles (Bam). Acts by binding to the promoter of miR-7 gene and repressing its expression; miR-7 repression alleviates the Bam repression by miR-7, thereby allowing differentiation in the germline stem cell (GSC) lineage (By similarity).
Similarity
Belongs to the maelstrom family.
Mass
53.409 kDa
Sequence
MPPKKHSGFMMFVNEWRDNNPEGRNLSIAQAVSRCGSIWEKMTAQQRGPYNSGAKNADVLTRVKKERLNCHGQVLSQVELEEREMAESQIHMKRCTERIVMDAKRSHDLENTKFVFVAFNYFTKAFTTDVYVPAEFSASEYSFNEGIMSVYSTLIDPGQIIFGQGSDAQHHSSTTHNLPLPPNALGEKNMGKLYRNILEYLSKIQEGKDATKPFVVFTKTDMVPFVKSCFRYLACENQDGSYENGDQIQVLDIQYLLFIQKKEVLDIAGVSDEKINLYVTDAYFLKDFFEFTPEISCQYHEENDRSKYCTQSLVMRWAYTFSDYMCSDLAISVQPGKHIPPKTKPNYRVIPANSSVHESSFDSFYSIPASCEKKEDSPTVLSPASSRRSLASSPYVPTDHTSFVGDLNKKDEFPSLDQRNKLAALIDLIQFFYRCPVQLCRPLFSAGYHLNDALEPPHDPRDLYGRPL

Gene
mael2
Protein
Protein maelstrom 2
Organism
Drosophila persimilis
Length
438 amino acids
Function
Involved both in the piRNA and miRNA metabolic processes. As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons. As a nuclear component, it is required for proper differentiation in the germline stem cell (GSC) lineage by repressing microRNA-7 (miR-7), thereby acting as an indirect regulator of bag-of-marbles (Bam). Acts by binding to the promoter of miR-7 gene and repressing its expression; miR-7 repression alleviates the Bam repression by miR-7, thereby allowing differentiation in the germline stem cell (GSC) lineage (By similarity).
Similarity
Belongs to the maelstrom family.
Mass
49.768 kDa
Sequence
MAPKKRNGFMTFVKEWQANNPVARGLSNSEAVAKCDPIWKSMGDQERGPYNSMAKNANVLERTAKKERLNCLGGSVAEMEIEKNEAISAELQMKRKIERIILTAKNSMELENEEFVFVSFNYFTKALTGDIYVPAEFSACRYSLKGGISSNYSTMINPGHIIYGQSRDAQDHSKTTHKLPLPPQAFGETNMGKLYIDIFNWLSVRNEEKLDQDPVIVYTTPELMPVVKSCFRYLASEAEIDEDERKIMVFDIHHLFYTLKKSVLDVAGVTNDRINFHVTNNFFVKDFFEYTEGISCDYHEKIDRSKYCTNSMVKRWGFTFSDYMCADLAIPLQPGKHIPLKVKPNYTITPASSSTNFDEISLDSYYSAPPRIQKEMGSRDLSPSSSHQSVSRAYVPRDHSVYGGTLDSDEEFPSLGGRRRQLPDKSHFNMGAGKKIAR

Gene
mael2
Protein
Protein maelstrom 2
Organism
Drosophila pseudoobscura pseudoobscura
Length
370 amino acids
Function
Involved both in the piRNA and miRNA metabolic processes. As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons. As a nuclear component, it is required for proper differentiation in the germline stem cell (GSC) lineage by repressing microRNA-7 (miR-7), thereby acting as an indirect regulator of bag-of-marbles (Bam). Acts by binding to the promoter of miR-7 gene and repressing its expression; miR-7 repression alleviates the Bam repression by miR-7, thereby allowing differentiation in the germline stem cell (GSC) lineage (By similarity).
Similarity
Belongs to the maelstrom family.
Mass
42.026 kDa
Sequence
MAQNKPNAFMAFVADWRACNRFGRGLSTSEAVAKCGPIWEGMSDRERGQYKSKAKDSNVLERESKTERLNCPGVHSKMQVEKNEAIDAELQMKRNIKRIVLKATNSMKLEEREFLFVSFNYFTKALNGDVYQPAELSACRFSLKGGISSNYSTMINPGHIIFGQTSDAQDHSRTTHKLPLPPNAMGEKNLGNLYSDTLKWLSASNDEEDEQYDHPVIVYTTPELMPVVKSCFRYLACEGDTDKHAEKIMVYDICYLFLTLKKTVLDLVGVPSDHMNIHVTNSFFRRDFFEFSSGIACDYHEEVDRTKYCTKSMVLRWGYMISHYICGDLAIPLQPRKHVPIEVKHSYTVTPGDSSLALDGTWTDSGYSGY