Protein
Macrolide export ATP-binding/permease protein MacB 3
Organism
Paracoccus denitrificans (strain Pd 1222)
Function
Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
Similarity
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
Sequence
MPLIRIRGLHRVFGEGAARAHVLRGIDLDIHAGEFVAIVGTSGSGKSTLMNILGLLDRPSAGSYHLAGKDVARLSRDARAGLRNRLFGFVFQQYNLIPTLTALENVELPASHAGAAREARRARAAALLRSLGLGHRLTARPLQMSGGQQQRVSIARALMNGGAVILADEPTGALDAESGRQVMRLLSDLAGRGHTVILITHDTDIAARAGRVIRVGEGRIAGDSGTRAAGPAVPVLPETTGSRSAFLHALREAARSALAAIGASPVRTALTLSGIVIGVASVVAMLAIGRGAQEEFVKRASAIGTNWVVVGSDQDTRMPRRPLTLDDAMALKGLPNVAGVMPGRWEQATVRAGAFSIDTDIIGTDRDFRGVHGWDVVRGSFFSEADERGGSPVLLLGSTVAGTLFPDGRDPTGEFVFVNMSPFLVGGVLESKGLSENGSDRDKVVAMPLRSLESRVYGPGELSVIVVALQDMARLDESNALLREAMIRRHGTEDFWLADAAGAFAAAEADRASQNLLLGAVATISIFVGGIGVMNIMFITVRERTREIGIRSATGAAMRDILVQFLTEATVLSALGGLAGLALAVGIGAVAALGLGMPVVFSVTVALGALAGATAMGAAFGLVPAIRAARLSPVEALASP