Protein
Macrolide export ATP-binding/permease protein MacB 1
Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Function
Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
Similarity
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
Sequence
MREPLLQLSGIRRHFGDGERRVEVLKGIDLTIARGEMVAIVGASGSGKSTLLNILGCLDQPSEGSYRVAGRETSRLTADALATLRREHFGFIFQRYHLLGDLSARDNVALPALYAGLAGDARKARAERLLQRLGLGSRLDYKPSQLSGGQQQRVSIARALINGGQVILADEPTGALDSQSGAEVLGILGALHRQGHTLVLVTHDMAIAEQAERIIELKDGAVVADRRREPTPPSPAPTTSRADTGGRGGLAGRLGAAFKMALLAMRAQRMRTFLTMLGIIIGIAAVVSVVALGRGSQQQVLANINAMGTSTLEIFPGSGFGDRRAEAVQTLRVEDAEALAGLGYVHSVTPSLATSVTLRRGSQAVLGSVNGVGEQFFQVRGYRLLQGMLFDAASVTALAQEVVIDENSLARLFGAGESPLGQVILLGSLPCRVIGVVARNQSGFGSDENLNVWIPHTTAMTRMLGQSHLRSISVRVQDEVALAAAEDGISRLLRERHGAQDFFVLNTDSIRQAITSTNATLTLLIAMIALISLVVGGIGVMNIMLVSVSERTREIGVRMAVGARTGDILQQFLIEAVLVCLLGGAAGVLLSLLIGVLFEHFSSQFTLSYSLDAVLMAFFCSSLIGVLFGFFPARRAARMDPIHALERE