Protein
NADP-dependent mannitol dehydrogenase
Organism
Hypocrea jecorina
Function
D-mannitol 2-dehydrogenase which is not necessary for D-mannitol catabolism. D-mannitol metabolism occurs via at least two different routes involving mannitol dehydrogenase (MDH) or mannitol 1-phosphate dehydrogenase, and the exact physiological role of mannitol dehydrogenases remains unclear.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Sequence
MPQPVPTANRLLDLFSLKGKVVVVTGASGPRGMGIEAARGCAEMGADLAITYSSRKEGAEKNAEELTKEYGVKVKVYKVNQSDYNDVERFVNQVVSDFGKIDAFIANAGATANSGVVDGSASDWDHVIQVDLSGTAYCAKAVGAHFKKQGHGSLVITASMSGHVANYPQEQTSYNVAKAGCIHLARSLANEWRDFARVNSISPGYIDTGLSDFIDEKTQELWRSMIPMGRNGDAKELKGAYVYLVSDASSYTTGADIVIDGGYTTR