Protein
N-acetyllactosaminide alpha-2,3-sialyltransferase
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Function
Catalyzes the transfer of sialic acid from the substrate CMP-N-acetylneuraminate to the terminal galactose residue of the N-acetyllactosamine moiety of surface lipooligosaccharide (LOS). Thus, functions in the sialylation of LOS, which plays a role in the evasion of the host immune response.
Similarity
Belongs to the glycosyltransferase 52 family.
Sequence
MNLMLCCTPLQVLIARKIIELHPNEQFFGVMFGGVWDKKRTLYASKLAEVCSDSMNIDTGKDLKGFDFLKLMRQLKNKITHKGFDKVFLANLNSLWLQTYLSHVSFKELYTFDDGSDNIFPHPNLLREPGTFKYKLIKAFIGDKYSVNKLFKKIKKHYTVYPNYKNIVSNIEPISLWDNQIDCEIDGEVSFFIGQPLLNTKEENISLIKKLKDQIPFDYYFPHPAEDYRVDGVNYVESELIFEDYVFKHLSNKKIIIYTFFSSVAFNLLSHPNVEIRFIRTSIPRWQFCYDSFPDLGLTIYKEI