About Products Protein Database Contact

lrk-1

Gene
lrk-1
Protein
Leucine-rich repeat serine/threonine-protein kinase 1
Organism
Caenorhabditis elegans
Length
2393 amino acids
Function
Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite-specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response.
Similarity
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.
Mass
266.322 kDa
Sequence
MDLSSGGPSSSSDVASELDNSDAMQLVRQAVLFENVELLADLFKVNPWVWNRVDRHGRTPLMLAAHNGKLDSLRTILMLSPNSLNLVNDRGKTALHMAAESGETSIVLELVELGSDPMKSDNEGHCALELAQMAGHNEVAAKLIDAIQKESEDLNEAHTMIISACISGSADVVYEISRRFMEKKQSREILFNGRNEEDETALLIACTNGHIEIVRHLLQFEEHLLQSHVSKDTVIHAAVSSQNVEVLQLCLEKFPQLVKSTNNEGSTCLHWAARCGSSECVSTILNFPFPSEFIIEIDTVGAPAYQLALDVNEVDGECRTAMYLAVAEGHLEVVKAMTDFKCTSIDGRQRCPFQLDVYCTRGRTPFMLAAFNQNLPLMTLLLDAGADVNLPLAVLDTEYSVEEGRCIGSGALVEAVRSDGLHIVHFLLDRGALDTDNKALRLAAQGKNEKLIRVFLVRLVFADPEYKINKKNIDVGQIQVGQSLLPSSLCPSKAAQLNWNSANLEQLQSDWFVAAALHVNPRLRTTRLSLAAITRVDLSDNRLNTFPSILFQMPSLRSLNLADNSIRKIEIPTYYISSTSLEILNLRNNQLECIAIQFLSSLPQLQQLDVSKNELSQLPEYIWLCPALKELNASYNRLSTLPMVARASRGERPRLNNSNNNFNTQSPTQESNPIVVDDPPNVTSNPLRRQNVWQASINLSKVDDDSLFPDFPVTSSNTLTTINLSFNKFHTFPFCLACTCPRLLILNMSNNSMTSLPPMACVPAHLRTLDLSYNKIQESFIEASPLHVVCHAVPPTTSNGSMLPKRRNSPARQHRSRSKSAVRSQRSLSVSRHHALIDPQKEEESCVHKRHDSLEWLKTLQLAGNRLRSISVTNAASKVLLPALNVMDISDNKLLQAPPDVARLTLLSMLNLSGNTAIKELPPDYGMLSRLWSLSLKGCSLKEPLESMVNVENCKTVEIVAYLKTILEESKTYHHLRLMILGSDGVGKSVIWDALCKEAVQKRQPIHSETGVIRQAEWKFEAKRSKGDKNLGPVGFSVIDFGGQREYHSTHQYFLSKRSLNLVLWKITDGDEALAQLDTWLVNIHARAPNSTVILVGTNLDQVASNSSKFGPGYIDIMEQKVRTRYMVADADKSGLPRIVDVILINSTSRNDVKALLNTIYRTAWEVRMGKERAMEQQIPSSYIALMKVTKELGVEFRKEGQPAVMTVEAYRERVKKRMISKFGRPFRDDIEFYAACTFLHDCGELVRFEDATLRDLIFVDPLWLAEFLTSVVILRSPNLPAGLLSTDAINPHTRSFKSGALLMLKTQLLDLLHKFELALATQPRQLLIPSLLPDEYRLRSDFLASAVKIRMKMSQWNVRCPSPAGSPTKSPLRRTSPTDQNGVGSEDVMLQFTYDDDQLLRRIYALAYIPSGFWSRLVTRIVGDKNVCAAIESIFMTTSADRAKIADIATKHAKAEWVVWQTGIELHVKGHSLFTLKQFLPLAEVRDIDYSAIDMRAKDEQKRWRTWNQPSHRPIVEMVVNSLSISAASQHGRKLSMKTDVEGRSRLLAMISDLLDTLLEDWYPALGTRFVHSSEGDLLVSRYVLCPQCVRDAERNGSRSRTSSSASHRRSQDDGELPITSSSHMKGSRTTGDISKCRGGVVHCFVIEECMLAGREYNWVECPSHGGLHMRELAPDTVFADIENALTIHPDQLKRSRMLGRGAFGFVFRATVRQPNGELCEVAQKMLEPVDPGPGGRPSALAAYKAAADKWKRDSMEFACRAYCTSRQELSLLSRMKHPNVIGLVGVCTFPLSLVVELAPLGALNQLLGSHRKAGTKLSLGVIKESAVQVARALEYLHSAHIIYRDLKSENVLGWRFPAPFSPQTDVLLKLGDYGISRSVLPSGGAKGFGGTEGFMAPEIVRFNGEEEYTQKVDCFSFGMFLYELLTLKFPFESEEHVKERMLDGARPVLLPHELLLPTPMLDLLVHCWSAHPESRPSSSQLVGFCAAPEFTHLLDVCELGEALPPTQLMAVGITDEIDDPDDFEAQLWLSGREMVVMGCTQYGFVDQKSIELPHRGKYVSKVRDSVWSCDECGQVTVYGISLHETGHLQLPSLNGTLICAPELISNDVLILISDKQIVLLKLSESNSVSHLGTIDSPYEIRTATFLGNGSTRQIWAGHSEGRISIHHIASNDSFSFSSSLYLPDDKCIVRQLVGSKDAQKVWIALEKSSKVQMVEVEKRQVTGSLDIRKVMPGSETIHTIDMEMASQNYVTCIGLLERNDGDQLYIGTSKGLLVIAHATTLQPLSACRPFEGDITSICILEEPSREEENTRGKATTLSTASSESGLGWVRERVSETVDRFRSSPATVETQGAALVVCIGRQFRSLSHRFVAEEKLADVYSIAVWRTEEWAL

Gene
lrk-1
Protein
Leucine-rich repeat serine/threonine-protein kinase 1
Organism
Caenorhabditis elegans
Length
2393 amino acids
Function
Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite-specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response.
Similarity
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.
Mass
266.322 kDa
Sequence
MDLSSGGPSSSSDVASELDNSDAMQLVRQAVLFENVELLADLFKVNPWVWNRVDRHGRTPLMLAAHNGKLDSLRTILMLSPNSLNLVNDRGKTALHMAAESGETSIVLELVELGSDPMKSDNEGHCALELAQMAGHNEVAAKLIDAIQKESEDLNEAHTMIISACISGSADVVYEISRRFMEKKQSREILFNGRNEEDETALLIACTNGHIEIVRHLLQFEEHLLQSHVSKDTVIHAAVSSQNVEVLQLCLEKFPQLVKSTNNEGSTCLHWAARCGSSECVSTILNFPFPSEFIIEIDTVGAPAYQLALDVNEVDGECRTAMYLAVAEGHLEVVKAMTDFKCTSIDGRQRCPFQLDVYCTRGRTPFMLAAFNQNLPLMTLLLDAGADVNLPLAVLDTEYSVEEGRCIGSGALVEAVRSDGLHIVHFLLDRGALDTDNKALRLAAQGKNEKLIRVFLVRLVFADPEYKINKKNIDVGQIQVGQSLLPSSLCPSKAAQLNWNSANLEQLQSDWFVAAALHVNPRLRTTRLSLAAITRVDLSDNRLNTFPSILFQMPSLRSLNLADNSIRKIEIPTYYISSTSLEILNLRNNQLECIAIQFLSSLPQLQQLDVSKNELSQLPEYIWLCPALKELNASYNRLSTLPMVARASRGERPRLNNSNNNFNTQSPTQESNPIVVDDPPNVTSNPLRRQNVWQASINLSKVDDDSLFPDFPVTSSNTLTTINLSFNKFHTFPFCLACTCPRLLILNMSNNSMTSLPPMACVPAHLRTLDLSYNKIQESFIEASPLHVVCHAVPPTTSNGSMLPKRRNSPARQHRSRSKSAVRSQRSLSVSRHHALIDPQKEEESCVHKRHDSLEWLKTLQLAGNRLRSISVTNAASKVLLPALNVMDISDNKLLQAPPDVARLTLLSMLNLSGNTAIKELPPDYGMLSRLWSLSLKGCSLKEPLESMVNVENCKTVEIVAYLKTILEESKTYHHLRLMILGSDGVGKSVIWDALCKEAVQKRQPIHSETGVIRQAEWKFEAKRSKGDKNLGPVGFSVIDFGGQREYHSTHQYFLSKRSLNLVLWKITDGDEALAQLDTWLVNIHARAPNSTVILVGTNLDQVASNSSKFGPGYIDIMEQKVRTRYMVADADKSGLPRIVDVILINSTSRNDVKALLNTIYRTAWEVRMGKERAMEQQIPSSYIALMKVTKELGVEFRKEGQPAVMTVEAYRERVKKRMISKFGRPFRDDIEFYAACTFLHDCGELVRFEDATLRDLIFVDPLWLAEFLTSVVILRSPNLPAGLLSTDAINPHTRSFKSGALLMLKTQLLDLLHKFELALATQPRQLLIPSLLPDEYRLRSDFLASAVKIRMKMSQWNVRCPSPAGSPTKSPLRRTSPTDQNGVGSEDVMLQFTYDDDQLLRRIYALAYIPSGFWSRLVTRIVGDKNVCAAIESIFMTTSADRAKIADIATKHAKAEWVVWQTGIELHVKGHSLFTLKQFLPLAEVRDIDYSAIDMRAKDEQKRWRTWNQPSHRPIVEMVVNSLSISAASQHGRKLSMKTDVEGRSRLLAMISDLLDTLLEDWYPALGTRFVHSSEGDLLVSRYVLCPQCVRDAERNGSRSRTSSSASHRRSQDDGELPITSSSHMKGSRTTGDISKCRGGVVHCFVIEECMLAGREYNWVECPSHGGLHMRELAPDTVFADIENALTIHPDQLKRSRMLGRGAFGFVFRATVRQPNGELCEVAQKMLEPVDPGPGGRPSALAAYKAAADKWKRDSMEFACRAYCTSRQELSLLSRMKHPNVIGLVGVCTFPLSLVVELAPLGALNQLLGSHRKAGTKLSLGVIKESAVQVARALEYLHSAHIIYRDLKSENVLGWRFPAPFSPQTDVLLKLGDYGISRSVLPSGGAKGFGGTEGFMAPEIVRFNGEEEYTQKVDCFSFGMFLYELLTLKFPFESEEHVKERMLDGARPVLLPHELLLPTPMLDLLVHCWSAHPESRPSSSQLVGFCAAPEFTHLLDVCELGEALPPTQLMAVGITDEIDDPDDFEAQLWLSGREMVVMGCTQYGFVDQKSIELPHRGKYVSKVRDSVWSCDECGQVTVYGISLHETGHLQLPSLNGTLICAPELISNDVLILISDKQIVLLKLSESNSVSHLGTIDSPYEIRTATFLGNGSTRQIWAGHSEGRISIHHIASNDSFSFSSSLYLPDDKCIVRQLVGSKDAQKVWIALEKSSKVQMVEVEKRQVTGSLDIRKVMPGSETIHTIDMEMASQNYVTCIGLLERNDGDQLYIGTSKGLLVIAHATTLQPLSACRPFEGDITSICILEEPSREEENTRGKATTLSTASSESGLGWVRERVSETVDRFRSSPATVETQGAALVVCIGRQFRSLSHRFVAEEKLADVYSIAVWRTEEWAL