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lprI

Gene
lprI
Protein
Lipoprotein LprI
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Length
197 amino acids
Function
Strongly binds and inhibits lysozyme, may help bacteria survive in lysozyme-producing host cells such as monocyte-derived macrophages.
Similarity
In the C-terminal section; belongs to the MliC family.
Mass
21.624 kDa
Sequence
MRWIGVLVTALVLSACAANPPANTTSPTAGQSLDCTKPATIVQQLVCHDRQLTSLDHRLSTAYQQALAHRRSAALEAAQSSWTMLRDACAQDTDPRTCVQEAYQTRLVQLAIADPATATPPVLTYRCPTQDGPLTAQFYNQFDPKTAVLNWKGDQVIVFVELSGSGARYGRQGIEYWEHQGEVRLDFHGATFVCRTS

Gene
lprI
Protein
Lipoprotein LprI
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
197 amino acids
Function
Strongly binds and inhibits lysozyme, may help bacteria survive in lysozyme-producing host cells such as monocyte-derived macrophages.
Similarity
In the C-terminal section; belongs to the MliC family.
Mass
21.624 kDa
Sequence
MRWIGVLVTALVLSACAANPPANTTSPTAGQSLDCTKPATIVQQLVCHDRQLTSLDHRLSTAYQQALAHRRSAALEAAQSSWTMLRDACAQDTDPRTCVQEAYQTRLVQLAIADPATATPPVLTYRCPTQDGPLTAQFYNQFDPKTAVLNWKGDQVIVFVELSGSGARYGRQGIEYWEHQGEVRLDFHGATFVCRTS

Gene
lprI
Protein
Lipoprotein LprI
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
197 amino acids
Function
Strongly binds and inhibits lysozyme, may help bacteria survive in lysozyme-producing host cells. When overexpressed in M.tuberculosis or M.smegmatis increases resistance to hen egg white lysozyme. M.smegmatis overexpressing LprI survive better during intracellular infection of peritoneal and monocyte-derived macrophages, both of which produce lysozyme during infection; M.smegmatis does not encode this protein. Somewhat better survival is seen in human cell lines when M.smegmatis cells express both proteins from this operon, i.e. GlbN (HbN) and LprI.
Similarity
In the C-terminal section; belongs to the MliC family.
Mass
21.624 kDa
Sequence
MRWIGVLVTALVLSACAANPPANTTSPTAGQSLDCTKPATIVQQLVCHDRQLTSLDHRLSTAYQQALAHRRSAALEAAQSSWTMLRDACAQDTDPRTCVQEAYQTRLVQLAIADPATATPPVLTYRCPTQDGPLTAQFYNQFDPKTAVLNWKGDQVIVFVELSGSGARYGRQGIEYWEHQGEVRLDFHGATFVCRTS

Gene
lprI
Protein
Lipoprotein LprI
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Length
197 amino acids
Function
Strongly binds and inhibits lysozyme, may help bacteria survive in lysozyme-producing host cells such as monocyte-derived macrophages.
Similarity
In the C-terminal section; belongs to the MliC family.
Mass
21.624 kDa
Sequence
MRWIGVLVTALVLSACAANPPANTTSPTAGQSLDCTKPATIVQQLVCHDRQLTSLDHRLSTAYQQALAHRRSAALEAAQSSWTMLRDACAQDTDPRTCVQEAYQTRLVQLAIADPATATPPVLTYRCPTQDGPLTAQFYNQFDPKTAVLNWKGDQVIVFVELSGSGARYGRQGIEYWEHQGEVRLDFHGATFVCRTS

Gene
lprI
Protein
Lipoprotein LprI
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
197 amino acids
Function
Strongly binds and inhibits lysozyme, may help bacteria survive in lysozyme-producing host cells such as monocyte-derived macrophages.
Similarity
In the C-terminal section; belongs to the MliC family.
Mass
21.624 kDa
Sequence
MRWIGVLVTALVLSACAANPPANTTSPTAGQSLDCTKPATIVQQLVCHDRQLTSLDHRLSTAYQQALAHRRSAALEAAQSSWTMLRDACAQDTDPRTCVQEAYQTRLVQLAIADPATATPPVLTYRCPTQDGPLTAQFYNQFDPKTAVLNWKGDQVIVFVELSGSGARYGRQGIEYWEHQGEVRLDFHGATFVCRTS

Gene
lprI
Protein
Lipoprotein LprI
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
197 amino acids
Function
Strongly binds and inhibits lysozyme, may help bacteria survive in lysozyme-producing host cells. When overexpressed in M.tuberculosis or M.smegmatis increases resistance to hen egg white lysozyme. M.smegmatis overexpressing LprI survive better during intracellular infection of peritoneal and monocyte-derived macrophages, both of which produce lysozyme during infection; M.smegmatis does not encode this protein. Somewhat better survival is seen in human cell lines when M.smegmatis cells express both proteins from this operon, i.e. GlbN (HbN) and LprI.
Similarity
In the C-terminal section; belongs to the MliC family.
Mass
21.624 kDa
Sequence
MRWIGVLVTALVLSACAANPPANTTSPTAGQSLDCTKPATIVQQLVCHDRQLTSLDHRLSTAYQQALAHRRSAALEAAQSSWTMLRDACAQDTDPRTCVQEAYQTRLVQLAIADPATATPPVLTYRCPTQDGPLTAQFYNQFDPKTAVLNWKGDQVIVFVELSGSGARYGRQGIEYWEHQGEVRLDFHGATFVCRTS