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lprF

Gene
lprF
Protein
Putative diacylated glycolipid transporter LprF
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Length
261 amino acids
Function
Might be involved in transporting short diacylated glycolipids to the cell outer membrane. Binds glycolipids that contain a diacylated glycerophosphate or a diacylated phosphatidylinositol moiety with C14 and C16 chains (upon overexpression in M.smegmatis; M.smegmatis does not encode this gene). Overexpression in M.smegmatis increases the cell wall glycolipid LAM/LM ratio (lipoarabinomannan/lipomannan), suggesting perhaps this protein is involved in the preferential translocation of diacylated LAM to the outer cell membrane. Overexpressing M.smegmatis cells adhere less well to hexadecane droplets, indicating decrease in the hydrophobicity of the cell surface, and have a slightly increased resistance to the antibiotic ethambutol.
Similarity
Belongs to the LppX/LprAFG lipoprotein family.
Mass
26.852 kDa
Sequence
MNGLISQACGSHRPRRPSSLGAVAILIAATLFATVVAGCGKKPTTASSPSPGSPSPEAQQILQDSSKATKGLHSVHVVVTVNNLSTLPFESVDADVTNQPQGNGQAVGNAKVRMKPNTPVVATEFLVTNKTMYTKRGGDYVSVGPAEKIYDPGIILDKDRGLGAVVGQVQNPTIQGRDAIDGLATVKVSGTIDAAVIDPIVPQLGKGGGRLPITLWIVDTNASTPAPAANLVRMVIDKDQGNVDITLSNWGAPVTIPNPAG

Gene
lprF
Protein
Putative diacylated glycolipid transporter LprF
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
261 amino acids
Function
Might be involved in transporting short diacylated glycolipids to the cell outer membrane (By similarity).
Similarity
Belongs to the LppX/LprAFG lipoprotein family.
Mass
26.852 kDa
Sequence
MNGLISQACGSHRPRRPSSLGAVAILIAATLFATVVAGCGKKPTTASSPSPGSPSPEAQQILQDSSKATKGLHSVHVVVTVNNLSTLPFESVDADVTNQPQGNGQAVGNAKVRMKPNTPVVATEFLVTNKTMYTKRGGDYVSVGPAEKIYDPGIILDKDRGLGAVVGQVQNPTIQGRDAIDGLATVKVSGTIDAAVIDPIVPQLGKGGGRLPITLWIVDTNASTPAPAANLVRMVIDKDQGNVDITLSNWGAPVTIPNPAG

Gene
lprF
Protein
Putative diacylated glycolipid transporter LprF
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
261 amino acids
Function
Might be involved in transporting short diacylated glycolipids to the cell outer membrane (By similarity). Overexpression induces expression of sensor protein kdpD gene at low K(+) concentrations (0 and 250 uM, tested in M.smegatis).
Similarity
Belongs to the LppX/LprAFG lipoprotein family.
Mass
26.852 kDa
Sequence
MNGLISQACGSHRPRRPSSLGAVAILIAATLFATVVAGCGKKPTTASSPSPGSPSPEAQQILQDSSKATKGLHSVHVVVTVNNLSTLPFESVDADVTNQPQGNGQAVGNAKVRMKPNTPVVATEFLVTNKTMYTKRGGDYVSVGPAEKIYDPGIILDKDRGLGAVVGQVQNPTIQGRDAIDGLATVKVSGTIDAAVIDPIVPQLGKGGGRLPITLWIVDTNASTPAPAANLVRMVIDKDQGNVDITLSNWGAPVTIPNPAG