Protein
4'-phosphopantetheinyl transferase
Organism
Bacillus subtilis
Function
May activate the peptidyl carrier protein (PCP) domains of surfactin synthetase SRF1/2/3 and iturin A synthetase, by transferring the 4'-phosphopantetheinyl moiety of coenzyme A (CoA) to a serine residue. Required for the coproduction of the lipopeptide antibiotics, iturin A and surfactin.
Similarity
Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.
Sequence
MKIYGVYMDRPLSAGEEDRMMAAVSAEKREKCRRFYHKEDAHRTLIGDMLIRTAAAKAYGLDPAGISFGVQEYGKPYIPALPDMHFNISHSGRWIVCAVDSKPIGIDIEKMKPGTIDIAKRFFSPTEYSDLQAKHPDQQTDYFYHLWSMKESFIKQAGKGLSLPLDSFSVRLKDDGHVSIELPDGHEPCFIRTYDADEEYKLAVCAAHPDFCDGIEMKTYEELL