lox

L-amino-acid oxidase

696 amino acids

Belongs to the flavin monoamine oxidase family.

77.013 kDa

MKWSAAAGAALLALPANSAVTASLPLKLETRSSLNSRLSNIHVERSASVEGAISYTYGSCQAKREEEAHHSISQPTDAHHDRLVWVIPENVQSGGCISAWSRANGRLVGRSRPQSFDFKSIKMRRDLKARATKPSDSVAIHMTTDNGINPWGPWFDGVKLLEDKEISTVDVEKAKSKNIAIVGAGMSGLMTYLCLTQAGMTNVSIIEGGNRLGGRVHTEYLSGGPFDYSYQEMGPMRFPNTITLGNETYNVSDHQLVFQLAEEMNSLNGHSKNLSVDFIPWYQSNSNGLYYYDGIKNPETGLPPTLAELAANSSLALTRVSNNSTKSLSQKVDAFLPDTDKFFAEMAQNMFKAHADWLSGGLAGLPGDQWSEFGFMVNYLRGSLNDTAFLSASAHSYWDTLYEGMYFSASTWKTIDGGLNRLPLSFHPLVDNATTLNRRVERVAFDAETQKVTLHSRNSYKDSFESSEHDYAVIAAPFSIVKKWRFSPALDLTAPTLANAIQNLEYTSACKVALEFRTRFWEHLPQPIYGSCSTTSDIPGIGSICYPSYNINGTDGPASILASYISGADWGDRWVSTPEEEHVQYVLNAMAEIHGEELVKEQYTGQFNRRCWALDPLESASWASPTVGQHELYLPEYFQTRNNLVFVGEHTSYTHAWIASALESGIRGSVQLLLELGLVDEAKATVDKWMARWIDV

lox

Linoleate 9/13-lipoxygenase

685 amino acids

In presence of oxygen, converts linoleate into (9S)-hydroperoxy-10,12-octadecenoate (9HPOD), which spontaneously decomposes to the corresponding 9-hydroxy-10,12-octadecenoate (9HOD), and into 13-hydroperoxy-9,11-octadecenoate (13HPOD) which spontaneously decomposes to the corresponding 13-hydroxy-9,11-octadecenoate (13HOD). Also active on linolenate. To a lesser extent, is also able to convert oleate into (10S)-hydroperoxy-8E-octadecenoate, which spontaneously decomposes to the corresponding 10-hydroxy-8E-octadecenoate. Is almost not active on arachidonate.

Belongs to the lipoxygenase family.

74.519 kDa

MKRRSVLLSGVALSGTALANDSIFFSPLKYLGAEQQRSIDASRSLLDNLIPPSLPQYDNLAGKLARRAVLTSKKLVYVWTENFANVKGVPMARSVPLGELPNVDWLLKTAGVIVELIVNFVASLPASAAAQFERIAAGLSGDLEAARQVHEALLEEAKNDPAAAGSLLLRFTELQTRVIALLTRVGLLVDDILKSASNLVTQGGQGDGLNRFRAVFGTLRLPEVADSFRDDEAFAYWRVAGPNPLLIRRVDALPANFPLGEEQFRRVMGADDSLLEAAASRRLYLLDYAELGKLAPSGAVDKLLTGTGFAYAPIALFALGKDRAGLLPVAIQCGQDPATHPMFVRPAESESDLYWGWQMAKTVVQVAEENYHEMFVHLAQTHLVSEAFCLATQRTLAPSHPLHVLLAPHFEGTLFINEGAARILLPSAGFIDVMFAAPIQDTQATAGGNRLGFDFYRGMLPESLKARNVDDPAALPDYPYRDDGLLVWNAIRQWAADYVAVYYASDGDVTADVELAAWVGEVIGSGKVAGFRPITGRSQLVEVLTMVIFTASAQHAAVNFPQPSMMTYAPAICAMSAAPAPDSPSGKSEADWLKMMPPTLVALEKVNIYHLLGSVYHGRLGDYRQTGFPYAPVFSDRRVTASGGPLERFQARLKEVEATIRTRNQARRKPYEYLLPSRIPASTNI

LOX

Protein-lysine 6-oxidase

420 amino acids

In addition to cross linking of extracellular matrix proteins, it may have a direct role in tumor suppression.

Belongs to the lysyl oxidase family.

48.153 kDa

MRCAPPGLLLAQLHACIFWSGLWPAGCQSPPAAWRQRIQWENNGQVYSLLSQGAQYQPPRRRQGAEPASSPVLLLRGNGSVPRAAAAAAARPQPEPQPQAQPQPRPRSSRRQPLGRRHWFQAGYRAPSGSARPAPRRRPRGRRSRRRERAERRRAAAPSGLRPGREDVMVGDDPYSPYKYTDDNPYYNYYDTYERPRQGSRYRPGYGTGYFQYGLPDLVPDPYYIQASTYVQRMSMYNLRCAAEENCLASSAYRADVRDYDNRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDASSHRKVAEGHKASFCLEDTSCDYGYYRRYACTAHTQGLSPGCYDTYNADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYSNNIVRCDIRYTGHHAYASGCTISPY

LOX

Protein-lysine 6-oxidase

418 amino acids

Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity).

Belongs to the lysyl oxidase family.

47.115 kDa

MRFAWTALLGSLQLCALVRCAPPAASHRQPPREQAAAPGAWRQKIQWENNGQVFSLLSLGSQYQPQRRRDPGATAPGAANATAPQMRTPILLLRNNRTAAARVRTAGPSAAAAGRPRPAARHWFQAGYSTSGAHDAGTSRADNQTAPGEVPTLSNLRPPNRVEVDGMVGDDPYNPYKYTDDNPYYNYYDTYERPRPGSRYRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMAMYNLRCAAEENCLASSAYRXDVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDASTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYNADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYSNNVVRCEIRYTGHHAYASGCTISPY

LOX

Protein-lysine 6-oxidase

417 amino acids

Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity).

Belongs to the lysyl oxidase family.

46.944 kDa

MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSLGSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPTARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY

Lox

Protein-lysine 6-oxidase

411 amino acids

Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (PubMed:27432961).

Belongs to the lysyl oxidase family.

46.701 kDa

MRFAWAVLLLGPLQLCPLLRCAPQTPREPPAAPGAWRQTIQWENNGQVFSLLSLGAQYQPQRRRDPSATARRPDGDAASQPRTPILLLRDNRTASTRARTPSPSGVAAGRPRPAARHWFQAGFSPSGARDGASRRAANRTASPQPPQLSNLRPPSHIDRMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGSRNRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMSMYNLRCAAEENCLASSAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYAADIDCQWIDITDVQPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY

Lox

Protein-lysine 6-oxidase

411 amino acids

Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:16432278). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity).

Belongs to the lysyl oxidase family.

46.559 kDa

MRFAWTVLFLGQLQFCPLLRCAPQAPREPPAAPGAWRQTIQWENNGQVFSLLSLGAQYQPQRRRDSSATAPRADGNAAAQPRTPILLLRDNRTASARARTPSPSGVAAGRPRPAARHWFQVGFSPSGAGDGASRRAANRTASPQPPQLSNLRPPSHVDRMVGDDPYNPYKYSDDNPYYNYYDTYERPRSGSRHRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMSMYNLRCAAEENCLASSAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDASTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYAADIDCQWIDITDVQPGNYILKVSVNPSYLVPESDYSNNVVRCEIRYTGHHAYASGCTISPY

LOX

Protein-lysine 6-oxidase

249 amino acids

Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity).

Belongs to the lysyl oxidase family.

29.073 kDa

DDPYNPYKYSDDNPYYNYYXXXERPRPGSRYRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDASTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYNADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYSNNVVRCEIRYTGHHAYASGCTISPY