lonp-1

Lon protease homolog, mitochondrial

971 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. Involved in the degradation of transcription factor atfs-1 in the mitochondrion (PubMed:22700657).

Belongs to the peptidase S16 family.

108.206 kDa

MYRAGAVLLRGATRTRLLAAASAHQSFATFSQRNQSILMMKSMELAGNSGERRFYSTHDDPIAVDDSLELYKDLGGMSPIQVPADMPNVPMLAINRYPLFPGFIKKVDIVKDDNLKALIRRQLSLKQPYAGVFVKRDDENKEETITSLSEVYPTGSFVQIIEVRDQGSVLELVLSAHRRIRALEPIDEITPKNETPLNGRRARGKRAASATSPLTPPPSPPPLAPSVASVAPEISATEEKEEKTTPPSATGEKQKKGIIMVRTENVVAEPVPKNNETKATMMAIVQTIRDVVQFNQLFGQQINLLLHPSQNVIDNPVYLCDLVATLVQSAETKDLQEMMDEIDVSKRLKIALLLIQKEKAVAKLKYDINKDVEKKVQDHHRKYLLNEQLKVIKKELGIEKDEKTTIIEKIDERIKTLAVPEYALKVINEEKTKLQFLDPHSSEFSVTRNYLEWLTSVPWGLTSPENRRLSVAKKALDEGHYGMKDVKERIMEFIAVNLLRKSIGGKILCFHGPPGVGKTSIAKSIATALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKMIQCMKKVKTENPLVLIDEVDKIGGAGFHGDPASALLELLDPEQNANFNDHFLDVPVDLSRVLFICTANEISKIPGPLRDRMEMIDVSGYLAEEKVEIAHQHLIPQLRKDTSLATEQLKIEDSALEELIKHYCRESGVRNLQQHIERIFRKAALQIAEQQNEDEEPAEKATTAITENSEAEPITSTSSADCLKSSAEQIVVCTENLQKFVGRPKFTSDRMYEVTPPGVIMGLAWTAMGGSALYIETVLKRPVDLTNDKDGSIETTGNLGDVMKESVRTALTVAKGILAREQPDNKFFDKAHIHIHVPEGATPKDGPSAGVTLVSSLLSLALDRPVVQDMAMTGEISLTGKVLPVGGIREKVIAARRVGAKRVFLPNENRRDFDDLPEFMKSELDIRFVSHYDELYEHLFQ

lonp-1

Lon protease homolog, mitochondrial

960 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Belongs to the peptidase S16 family.

106.955 kDa

MYRAGALVLRSATLRRTRFLAAHQNFATISSQRSSVLLAKSLESSIGGAGNQKKFYSSKDHDDPIAVDDSLELYKDLGGMSPIQVPADMPNVPILAINRYPLFPGFIKKVDIVKDDNLKALIRRQLSLKQPYAGVFVKKDDENKEETIVSLSEVYPTGSFVQIIEVRDQGSVLELVLSAHRRIRVIEPIEDVVAPKTDTPLNGRRARGKRAGLPPTPPPTPPLSTPTSAPEASATSPEEKEEKKDPERKGIVMVRTENVVADPVPKNNETKATMMAIVQTIRDVVQFNQLFGQQINLLLHPSQNVIDNPVYLCDLVATLVQSAETKDLQEMMDETDVSKRLKIALLLIQKEKAVAKLKHDINKDVEKKVQDHHRKYLLNEQLKVIKKELGIEKDEKTTIIEKIDERMKTLAVPEYALKVINEEKTKLQFLDPHSSEFSVTRNYLEWLTSVPWGLTSPENRRLSHAKKALDEGHYGMKDVKERIMEFIAVNLLRKSVGGKILCFHGPPGVGKTSIAKSIANALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKMIQCMKKVKTENPLVLIDEVDKIGGAGFHGDPASALLELLDPEQNANFNDHFLDVPVDLSRVLFICTANEISKIPGPLRDRMEMIDVSGYLAEEKVAIAHQHLIPQLRKETSLSADQLNIEDSALEELIKHYCRESGVRNLQQHIERIFRKAALQIAEQQPEDEQPAATTAISENSDAEPVSTPSDPPTFTPEKINISTENLQKFVGRPKFTSDRMYEVTPPGVIMGLAWTAMGGSALYIETVLKRPVDVTSDKDGSIETTGNLGDVMKESVRTALTVSKGILAREQPDNKFFDKSHIHIHVPEGATPKDGPSAGVTLVSSLLSLALNRPVVQDMAMTGEISLTGKVLPVGGIREKIIAARRVGAKRVFLPAENRRDFDDLPEFMKSELDIRFVSHYDELYEHLFQ