lin-59

Probable histone-lysine N-methyltransferase lin-59

1312 amino acids

Probable histone methyltransferase (By similarity). Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin.

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.

147.583 kDa

MHGAGEQQQRYRYNARSDEQHHHPSTSSHQYQQQGARQMHQMHPIQATLMCTPTTTSAAASTSSSGGSNSSGGSGGHRQQGNILRIGNSIKIGDNILEPAGTLVFSQADGTPWTGQRIVVNGSTHAVVKANLFPIGTTPPVLNMQSNQNWYMNQPSGTVPMSSNAPATTSSATPDSGIQSVPTSPPSPSYAMMNDVDIGDHDDEEDDDGPADFTDMPLLKPVDEDDDCYDVPCTSEGPPPNNSNPAITTIPSSCSTPAPPKESLPTGMNVEEWGSFLIASNMDREEIVRRLMAHDPEMAKAIAMRIRELSAEESKKKKDMEAEVSSTTPTTPRARGTRTRNKCATRSTNSPDVTTSNLPEEPSTSTMGLVKENEDVEKVEGKRRGRKPKKRRGFHKESFEDLESDAKKSKAEQHEDHLPEASCSSRPESVIPPPVDPIQFRLKVREMMERKLEQLTQKMSEDMTELRLSHLTSSKMVNGERGKRRESFLRQLNEQSKKLRKGGMLGRKRLRMFMTESDILEENKDNIKKEVKEESTPPPTKLRGRLPSRRTREPSEIVNPEPVEKKFNGEYFEITKSVPSSDDIIPLWMAPSLTCGCTKGACTSDMDCLNRALRVQCSSDCSVPYCSNRRFWKEDCGNKLCVSNGPRSKRVLKTKIARRAGEFLCEYAGEVITREQAQEKFAQDRDPRIIAIAAHLFVDATKRSNIARFIKHSCKPNSRLEVWSVNGFYRAGVFALSDLNPNAEITVDKSDLLPFDMACNCGATECKRVIRGVRWRCADPNEKIVTRRFVIRNRRKTIERSSHSGLPAILQTPMDENSSIRLKMKQVLAAFAFRVRKIDGSMSRTMLPHYTLIIKFLKTKGNNPNPVEFVSLFRKWLEAIDDDDLERAFVAIESHYMSSSILSSSLQSKKAKDNAPRARALSTSCPSPVPSKRGDADLSYLESLYPIGSYDPDDAWESYSTNKKGNAVRCICGALDEEGTMVQCDTCHFWLHVDCCQYVVRSNEKAQKSKNPPSDDGEYICDFCTNKQNGLRPSADVKLTEQPDVRFENCDYYRSLINRRGIQVVLNETVYVNRVLPEDHKAMLRNLREEKKGSKQKDTNKYRFPKAATSPLPIEKVDRKNARIFRVERLFVCPGNNRFVFGSFYAWPHETYADAGRVFSKKEVFATPYYETLPLDEVIGRCLVLDTATWCKGRPKVPKFKEDDVFLCEMQIGKTQRVFEKVPPKNRYPINTNSYVFTEFTHPKKVVRDFRPYDPSNPSPKPPKTSSIPSTSSIDPPQSSSDGLPEVDTKKLSKRHIQRVLKRLVKNGSRRS