lin-53

Gene

lin-53

Protein

Probable histone-binding protein lin-53

Organism

Caenorhabditis elegans

Length

417 amino acids

Function

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Required for hcp-3 and his-1 stabilization, localization of hcp-3 to centromeres and for proper chromosome segregation (PubMed:26904949). Synthetic multivulva class B (synMuvB) protein (PubMed:9875852). SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription (PubMed:9875852, PubMed:10704416, PubMed:17075059).

Similarity

Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.

Mass

47.166 kDa

Sequence

MATLEDGTSEDRVANDEYKIWKKNTPFLYDLVMTHALEWPSLSVQWLPDVAKDNSDHTIHRLILGTHTSDEQNHLLISKICMPTDDAQFDASRYDTERSEYGGFGAVNGKVEPDIRINHEGEVNRARYMPQKSNIIATKSPHADVYIFDYLKHSAVPRDNTFNPLIRLKGHTKEGYGLSWNPNKEGLILSASDDQTVCHWDINANQNVAGELQAKDVFKGHESVVEDVAWHVLHDGVFGSVGDDKKLLIWDVRTSTPGHCIDAHSAEVNCLAFNPYSEFILATGSADKTVALWDLRNLRMKLHSFESHRDEIFQVQWSPHNETILASSGTDKRLHVWDLSKIGEDQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVVCSVSEDNILQVWQMADNIYNEVDEETPADVVERQQ

Protein

Probable histone-binding protein lin-53: lin-53

Gene

lin-53

Protein

Probable histone-binding protein lin-53

Organism

Caenorhabditis briggsae

Length

416 amino acids

Function

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Required for hcp-3 and his-1 stabilization, localization of hcp-3 to centromeres and for proper chromosome segregation. Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription.

Similarity

Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.

Mass

46.919 kDa

Sequence

MATIEDGTSEDRVANDEYKIWKKNTPFLYDLVMTHALEWPSLSVQWLPEIEKESSDHTVHRLILGTHTSDEQNHLLISKICMPTDEAQFDASRYDTERGEFGGFGAVNGKVEPDIRINHEGEVNRARYMPQKPTIIATKSPSADVYIFDYTKYPSVPKDNTFNPLLKLKGHTKEGYGLSWNPNKEGLILSASDDQTVCHWDINGNAGANGELKAREIFKGHESVVEDVAWHVLHDGVFGSVGDDKKLLIWDLRTNVPGHAIDAHSAEVNCLAFNPYSEFILATGSADKTVALWDLRNLRLKLHSFESHRDEIFQVQWSPHNETILASSGTDKRLHVWDLSKIGEDQTAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVVCSVSEDNILQVWQMADNIYNDVEDETPADMVERS

Protein

Probable histone-binding protein lin-53: lin-53