Function
Probable ligand for tyrosine kinase receptor let-23. Essential for vulval induction, where it acts downstream of the synthetic multivulva (synMuv) class genes (PubMed:1641037, PubMed:17891142, PubMed:16678779). Probably by activating let-23, phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signaling cascade, plays a role in ovulation by promoting gonadal sheath cell contractions and spermatheca dilatation during ovulation (PubMed:15194811, PubMed:9491893). Probably by regulating neuronal transmission in ALA neurons, mediates the decrease in pharyngeal pumping and locomotion during the quiescent state that precedes each larval molt, by activating receptor lin-23-mediated signaling cascade (PubMed:17891142).
Sequence
MRKMLLFCILLLFMPQFTVSESCLPSWFRQERSAPEQLQSAENAAENSGSVPPDTSRNSLETNEIGDAPSSTSTPETPTETTISEAGDDEKRTEEVAKELIEKEAEYEGEYEDEKVDEEVEEALKYNEDATQDATSTLKPAVRKEIEKLKEAKCKDYCHHNATCHVEVIFREDRVSAVVPSCHCPQGWEGTRCDRHYVQAFYAPINGRYNVRLSTMSSTAQLLVQQSSTSAIPAFAFLIVMLIMFITIVVYAYRRMSKRSDDMTYTMSHMCPPEAFNVLKTPNGRHIPVHQIPSCSYTIPTPGTVPPNISSTPGSRIPTRQQAIRNNEQARNNFFSILRSQGTIPSRSINDDDTPKHYKSVPRVEVSAINYSGHIDFSTVSYQSTESEVSKASVTCPPPAHTVINIELDSADTNFRSPSRSSGEQGSPATCEPMIRHT