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limC

Gene
limC
Protein
(-)-trans-carveol dehydrogenase
Organism
Rhodococcus erythropolis
Length
277 amino acids
Function
Catalyzes the oxidation of carveol to carvone, with a strong stereoselectivity since it efficiently converts only the (6S)-stereoisomers, of which (-)-(4R,6S)-trans-carveol is the better substrate. Displays a broad substrate specificity with a preference for substituted cyclohexanols, and does not catalyze the oxidation of primary or short chain aliphatic secondary alcohols. Is also able, albeit more slowly, to oxidize limonene-1,2-diol into 1-hydroxy-2-oxolimonene.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
29.531 kDa
Sequence
MARVEGQVALITGAARGQGRSHAIKLAEEGADVILVDVPNDVVDIGYPLGTADELDQTAKDVENLGRKAIVIHADVRDLESLTAEVDRAVSTLGRLDIVSANAGIASVPFLSHDIPDNTWRQMIDINLTGVWHTAKVAVPHILAGERGGSIVLTSSAAGLKGYAQISHYSAAKHGVVGLMRSLALELAPHRVRVNSLHPTQVNTPMIQNEGTYRIFSPDLENPTREDFEIASTTTNALPIPWVESVDVSNALLFLVSEDARYITGAAIPVDAGTTLK

Gene
limC
Protein
LIM domain-containing protein C
Organism
Dictyostelium discoideum
Length
182 amino acids
Function
Binds to F-actin and may modulate the chemotactic response during early development and contribute to the maintenance of the strength of the actin cytoskeleton.
Mass
20.555 kDa
Sequence
MSSICPTCTKRVYAAEAVKACEKQYHKLCLQCFHCHKILQLGQYSERDGQPYCKTDYDRLFRQAGYRGGGVVADSFEPAPKVETTTPVEPTPPPTFLTPTEEVKVQLFPTNCPKCGKKAYFNELKVYNSRDWHKTCFACFSCNKNLVSGQYSEKEGLIYCPRCYQSKFGPSGYTNTGALVLH