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lig3

Gene
lig3
Protein
DNA ligase 3
Organism
Dictyostelium discoideum
Length
1175 amino acids
Function
The alpha isoform interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. The beta isoform does not interact with XRCC1 and may be specifically involved in the completion of homologous recombination events that occur during meiotic prophase.
Similarity
Belongs to the ATP-dependent DNA ligase family.
Mass
132.048 kDa
Sequence
MSEDKSGSFYSMYKLCGQLEKESSHSGKTQLIKSFCNVFKGDLYLLAKLMLCKEDKRVFRIKDKAMLKICSHIWDCDLDDMIEDLDNGDFTETCKKFYIEYGKYPEKSTLTLKEVDQVLDSLTVSGKFEDQVKIINKLLKRCTPFDFRLVCRIIDSDLKINTGAKFFLDAFHPQAYDAFKKANNLKGVIEKIQQHDFDNDNGDGDDGDGDDNDDDDGDGDSDSDKKKKKSSGGSGSDSGSKKKSKSFEVAIKLMTPIKPMLPKAVKTVEGVVKSSECFYAEIKYDGERIQIHKDGNQFSCYSRNLKPLMPWKVDEVKPYIPKSTKAQQMILDGEILLMDTKTSQPLPFGTLSAHKKNGFKDATVCVFLFDILYLNGKSLIHLPLKERREILEKNVMVVKNRIEFSEVTIVNGASEKSKLTALLNRVFKEKLEGLVIKDAMSEYEPGCRHWIKIKKDYIHGMADSADLIAVGGYYGSGSMGGLVTVFLMVCYDKQNKIYKTVVKASGGLDDNMIAKLQPKVTSTMTKISKEVSKIPYWLDCPKQYAPDFIVKDIKQAMIFEIESAEFTKSDHHTTGYSMRFPRILKIRHDKDYKTATTLEELVEIGKDIKIVPVGKGDNNSPTTTTTTTTTTTTTTSSKLIKKQQLSDDDDDNDKDSKQQQQEPSKLKFVSDDLLDPFNDKSDDESNKIFILNYVDNSGIWNEKGLSGAIGKKWPSIPKSFSQGDSNIIKSGEIRVEKVKDDSISTNKKVFICNLSCIIPPKSKKESYTFSLKEFKSAIKEAKGAINQKKASVHLAKPQFTSPSWSELDEVLTKELYNSGIKVFVHSISKSSPTTTSPTTTSPTTTSPKITSPSSSSSPSNKLSPLKRGRDEKLEHEIIKDIEPSLPIFEDVNAVIDSKTIDQVDVKRLINSIKTMGGRVSDKWQQVGIGKTTHLICNGMSDLYLHVDRLGGTIVLPNWVDQCFGSDKLLPLHEDYIYFNKKDHPDYSQSSSSSSMSIEEEKIVVTTTSDDPSEGNQQQQDKKVIKESKIIQSKDHSSTTTIDTKITITSTNNNNNGNDNNKTRKKQHLLSIFQECIIFLHDNVNDRETLKRYIIAYGGDISDSVNDKTTHLVASLPNNFSNVKPKDLFKSIINNNSKNNNNNNNNNNNGIIVNSLWLWDSINMSDLLDVKNYKLF

Gene
lig3
Protein
DNA ligase 3
Organism
Dictyostelium discoideum
Length
1175 amino acids
Function
The alpha isoform interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. The beta isoform does not interact with XRCC1 and may be specifically involved in the completion of homologous recombination events that occur during meiotic prophase.
Similarity
Belongs to the ATP-dependent DNA ligase family.
Mass
132.048 kDa
Sequence
MSEDKSGSFYSMYKLCGQLEKESSHSGKTQLIKSFCNVFKGDLYLLAKLMLCKEDKRVFRIKDKAMLKICSHIWDCDLDDMIEDLDNGDFTETCKKFYIEYGKYPEKSTLTLKEVDQVLDSLTVSGKFEDQVKIINKLLKRCTPFDFRLVCRIIDSDLKINTGAKFFLDAFHPQAYDAFKKANNLKGVIEKIQQHDFDNDNGDGDDGDGDDNDDDDGDGDSDSDKKKKKSSGGSGSDSGSKKKSKSFEVAIKLMTPIKPMLPKAVKTVEGVVKSSECFYAEIKYDGERIQIHKDGNQFSCYSRNLKPLMPWKVDEVKPYIPKSTKAQQMILDGEILLMDTKTSQPLPFGTLSAHKKNGFKDATVCVFLFDILYLNGKSLIHLPLKERREILEKNVMVVKNRIEFSEVTIVNGASEKSKLTALLNRVFKEKLEGLVIKDAMSEYEPGCRHWIKIKKDYIHGMADSADLIAVGGYYGSGSMGGLVTVFLMVCYDKQNKIYKTVVKASGGLDDNMIAKLQPKVTSTMTKISKEVSKIPYWLDCPKQYAPDFIVKDIKQAMIFEIESAEFTKSDHHTTGYSMRFPRILKIRHDKDYKTATTLEELVEIGKDIKIVPVGKGDNNSPTTTTTTTTTTTTTTSSKLIKKQQLSDDDDDNDKDSKQQQQEPSKLKFVSDDLLDPFNDKSDDESNKIFILNYVDNSGIWNEKGLSGAIGKKWPSIPKSFSQGDSNIIKSGEIRVEKVKDDSISTNKKVFICNLSCIIPPKSKKESYTFSLKEFKSAIKEAKGAINQKKASVHLAKPQFTSPSWSELDEVLTKELYNSGIKVFVHSISKSSPTTTSPTTTSPTTTSPKITSPSSSSSPSNKLSPLKRGRDEKLEHEIIKDIEPSLPIFEDVNAVIDSKTIDQVDVKRLINSIKTMGGRVSDKWQQVGIGKTTHLICNGMSDLYLHVDRLGGTIVLPNWVDQCFGSDKLLPLHEDYIYFNKKDHPDYSQSSSSSSMSIEEEKIVVTTTSDDPSEGNQQQQDKKVIKESKIIQSKDHSSTTTIDTKITITSTNNNNNGNDNNKTRKKQHLLSIFQECIIFLHDNVNDRETLKRYIIAYGGDISDSVNDKTTHLVASLPNNFSNVKPKDLFKSIINNNSKNNNNNNNNNNNGIIVNSLWLWDSINMSDLLDVKNYKLF

Gene
Lig3
Protein
DNA ligase 3
Organism
Mus musculus
Length
1015 amino acids
Function
The alpha isoform interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. The beta isoform does not interact with XRCC1 and may be specifically involved in the completion of homologous recombination events that occur during meiotic prophase.
Similarity
Belongs to the ATP-dependent DNA ligase family.
Mass
113.072 kDa
Sequence
MTLAFKILFPRNLCALGRKELCLFPEQNRWAAISQFSQWSETNLLGGCCLLQRRKPVLALQRGHLRPRATHLTFWPGSHVGLCTGPCAMAEQRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARATTKKIEDLTELEGWEELEDNEKEQISQHIADLSSKAAATPKKKAAVQAKLTTTGQVTSPVKGASFITSTNPRKFSGFSAAKPNNSEQAPSSPAPGTSLSASKCDPKHKDCLLREFRKLCAMVAENPSYNTKTQIIHDFLQKGSTGGFSDGFHGDVYLTVKLLLPGVIKSVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRIFFEQSKSFPPAAKSLLTIQEVDAFLLHLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDVVERVLHNEQEVEKDPGRRRALRVQASLMTPVQPMLAEACKSIEYAMKKCPNGMFSEIKYDGERVQVHKKGDHFSYFSRSLKPVLPHKVAHFKDYIPKAFPGGQSMILDSEVLLIDNNTGKPLPFGTLGVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIRNRIMFSEMKQVTKASDLADMINRVIREGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPDSQKWCTVTKCAGGHDDATLARLQKELVMVKISKDPSKIPSWLKINKIYYPDFIVPDPKKAAVWEITGAEFSRSEAHTADGISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSKDKADFAVVAGDEASPTTGGSSGENEGTAGSAGPCKGPPSKSSASAKTTEQKLNSPSSRGGIKPIPKHSPMKPGEKLAVKSSPVKVGMKRKATDETPCLKKVLLDVFTGVRLYLPPSTPDFKRLKRYFVAFDGDLVQEFDMGSATHVLGNREKNTDAQLVSSEWIWACIRKRRLIAPC

Gene
Lig3
Protein
DNA ligase 3
Organism
Mus musculus
Length
1015 amino acids
Function
The alpha isoform interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. The beta isoform does not interact with XRCC1 and may be specifically involved in the completion of homologous recombination events that occur during meiotic prophase.
Similarity
Belongs to the ATP-dependent DNA ligase family.
Mass
113.072 kDa
Sequence
MTLAFKILFPRNLCALGRKELCLFPEQNRWAAISQFSQWSETNLLGGCCLLQRRKPVLALQRGHLRPRATHLTFWPGSHVGLCTGPCAMAEQRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARATTKKIEDLTELEGWEELEDNEKEQISQHIADLSSKAAATPKKKAAVQAKLTTTGQVTSPVKGASFITSTNPRKFSGFSAAKPNNSEQAPSSPAPGTSLSASKCDPKHKDCLLREFRKLCAMVAENPSYNTKTQIIHDFLQKGSTGGFSDGFHGDVYLTVKLLLPGVIKSVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRIFFEQSKSFPPAAKSLLTIQEVDAFLLHLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDVVERVLHNEQEVEKDPGRRRALRVQASLMTPVQPMLAEACKSIEYAMKKCPNGMFSEIKYDGERVQVHKKGDHFSYFSRSLKPVLPHKVAHFKDYIPKAFPGGQSMILDSEVLLIDNNTGKPLPFGTLGVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIRNRIMFSEMKQVTKASDLADMINRVIREGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPDSQKWCTVTKCAGGHDDATLARLQKELVMVKISKDPSKIPSWLKINKIYYPDFIVPDPKKAAVWEITGAEFSRSEAHTADGISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSKDKADFAVVAGDEASPTTGGSSGENEGTAGSAGPCKGPPSKSSASAKTTEQKLNSPSSRGGIKPIPKHSPMKPGEKLAVKSSPVKVGMKRKATDETPCLKKVLLDVFTGVRLYLPPSTPDFKRLKRYFVAFDGDLVQEFDMGSATHVLGNREKNTDAQLVSSEWIWACIRKRRLIAPC

Gene
LIG3
Protein
DNA ligase 3
Organism
Homo sapiens
Length
1009 amino acids
Function
Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).
Similarity
Belongs to the ATP-dependent DNA ligase family.
Mass
112.907 kDa
Sequence
MSLAFKIFFPQTLRALSRKELCLFRKHHWRDVRQFSQWSETDLLHGHPLFLRRKPVLSFQGSHLRSRATYLVFLPGLHVGLCSGPCEMAEQRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARATTKKIEDLTELEGWEELEDNEKEQITQHIADLSSKAAGTPKKKAVVQAKLTTTGQVTSPVKGASFVTSTNPRKFSGFSAKPNNSGEAPSSPTPKRSLSSSKCDPRHKDCLLREFRKLCAMVADNPSYNTKTQIIQDFLRKGSAGDGFHGDVYLTVKLLLPGVIKTVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQSKSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDVVERVLHNAQEVEKEPGQRRALSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEIKYDGERVQVHKNGDHFSYFSRSLKPVLPHKVAHFKDYIPQAFPGGHSMILDSEVLLIDNKTGKPLPFGTLGVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIPNRIMFSEMKRVTKALDLADMITRVIQEGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPGSQKWCTVTKCAGGHDDATLARLQNELDMVKISKDPSKIPSWLKVNKIYYPDFIVPDPKKAAVWEITGAEFSKSEAHTADGISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSKEKADFTVVAGDEGSSTTGGSSEENKGPSGSAVSRKAPSKPSASTKKAEGKLSNSNSKDGNMQTAKPSAMKVGEKLATKSSPVKVGEKRKAADETLCQTKVLLDIFTGVRLYLPPSTPDFSRLRRYFVAFDGDLVQEFDMTSATHVLGSRDKNPAAQQVSPEWIWACIRKRRLVAPC

Gene
LIG3
Protein
DNA ligase 3
Organism
Homo sapiens
Length
1009 amino acids
Function
Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).
Similarity
Belongs to the ATP-dependent DNA ligase family.
Mass
112.907 kDa
Sequence
MSLAFKIFFPQTLRALSRKELCLFRKHHWRDVRQFSQWSETDLLHGHPLFLRRKPVLSFQGSHLRSRATYLVFLPGLHVGLCSGPCEMAEQRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARATTKKIEDLTELEGWEELEDNEKEQITQHIADLSSKAAGTPKKKAVVQAKLTTTGQVTSPVKGASFVTSTNPRKFSGFSAKPNNSGEAPSSPTPKRSLSSSKCDPRHKDCLLREFRKLCAMVADNPSYNTKTQIIQDFLRKGSAGDGFHGDVYLTVKLLLPGVIKTVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQSKSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDVVERVLHNAQEVEKEPGQRRALSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEIKYDGERVQVHKNGDHFSYFSRSLKPVLPHKVAHFKDYIPQAFPGGHSMILDSEVLLIDNKTGKPLPFGTLGVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIPNRIMFSEMKRVTKALDLADMITRVIQEGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPGSQKWCTVTKCAGGHDDATLARLQNELDMVKISKDPSKIPSWLKVNKIYYPDFIVPDPKKAAVWEITGAEFSKSEAHTADGISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSKEKADFTVVAGDEGSSTTGGSSEENKGPSGSAVSRKAPSKPSASTKKAEGKLSNSNSKDGNMQTAKPSAMKVGEKLATKSSPVKVGEKRKAADETLCQTKVLLDIFTGVRLYLPPSTPDFSRLRRYFVAFDGDLVQEFDMTSATHVLGSRDKNPAAQQVSPEWIWACIRKRRLVAPC