Protein
Deoxyhypusine hydroxylase
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Function
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
Similarity
Belongs to the deoxyhypusine hydroxylase family.
Sequence
MSPSATDTTEGVDPTILTLRKVLTSESEPLARRFRALFSLKHLACLQPPTEKTLPAIQAIAAAFTSPSALLKHELAYCLGQTRNPESVPFLQQVAKDTEQDTMCRHEAAEALGALGYEDSLEILKALRDNQNESDVIRETCDIAVDRILWENSEARKAEKLKTSDFTSIDPAPPLPMTASEPSIPEIEKTLLDTSLPLFLRYRAMFALRDLASPPDLPTATRAVEALAKGLKDPSALFRHEIAFVFGQLCHPASIPSLTEALSNQSEAGMVRHEAAEALGSLGDCEGVEETLRKFLNDPEQVVRDSVIVALDMAEYEKNGEVEYALVPDAGVAAA