lia1

Gene

LIA1

Protein

Deoxyhypusine hydroxylase

Organism

Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)

Length

361 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

39.306 kDa

Sequence

MSVQVSPEQMATLKATLLNTPGNVPLHERFRALFMLKAVGGDEVVDIVSEGLKDPSPLLKHELAYVLGQLLNTRALPTLSRVLENPTGEHCSMVRHEAAEALGAIGAEESLPILRKYMQDENREVRETCEIAVGKIEFDLSEEGKKANANPDFPTIDPAPSAAPSDIPSLRADLLNTSLPLFQRYRAMFALRDFGAGSKEAVEALADGFRDGSALFRHEIAYIFGQLSSPYSIPSLLSRLRDAKEDDMVRHEAAEALGGIASDGVESENPEVVLPEDERLPEGGVLAVLREWAVKADAPTVVRESCQVAIDMWEYENSADQFNPLDSLSAKQEEREKTEKVNTTGMERSAHAAVAAMGIAA

Protein

Deoxyhypusine hydroxylase: LIA1

Gene

LIA1

Protein

Deoxyhypusine hydroxylase

Organism

Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)

Length

361 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

39.336 kDa

Sequence

MSVQVSPEQMATLKATLLNTPGNVPLHERFRALFMLKAVGGDEVVDIVSEGLKDPSPLLKHELAYVLGQLLNTRALPTLSRVLENPTGEHCSMVRHEAAEALGAIGAEESLPILRKYMQDENREVRETCEIAVGKIEFDLSEEGKKTNANPDFPTIDPAPSAAPSDIPSLRADLLNTSLPLFQRYRAMFALRDFGAGSKEAVEALADGFRDGSALFRHEIAYIFGQLSSPYSIPSLLSRLRDAKEDDMVRHEAAEALGGIASDGVESENPEVVLPEDERLPEGGVLAVLREWAVKADAPTVVRESCQVAIDMWEYENSADQFNPLDSLSAKQEEREKTEKVNTTGMERSAHAAVAAMGIAA

Protein

Deoxyhypusine hydroxylase: LIA1

Gene

LIA1

Protein

Deoxyhypusine hydroxylase

Organism

Ustilago maydis (strain 521 / FGSC 9021)

Length

360 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

39.145 kDa

Sequence

MDALEKSLCDFTGSTPLDQRFRSLFTIKGLAATSDQHMQRAISIISQAFSDDSALLKHELAYVLGQLEDARALPTLKKILQDLSQDAMVRHEAAEAMGAISDPSVLPILEQYRSDSDVSVRETCELAISKISFDNSEEGQALKQSKAQAKLAEEQSGLGGVESAFKPIDPAPAMTPAASKEAARSQADGVRYDASHVPLFQSTLLDTNLSLFERYRAMFALRNVAHGGGDGAIQAVLALARGLQDGSALFRHEICFVFGELCHPASIPSMLHVLNDTKEHEMVRHEAAEALGGIVEEGEHAANDSANDYTRVLDTLNKWAHDMDAPRVVRESCIVALDELAYNNDPTQFHRIETSTPVAA

Protein

Deoxyhypusine hydroxylase: LIA1

Gene

LIA1

Protein

Deoxyhypusine hydroxylase

Organism

Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)

Length

344 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

36.538 kDa

Sequence

MTAPTTTSPSSEATTTTTTTTLNTIATLHQSLTTETTPLPVRFRALFSLKHVAATHPATSAESLAAIDAIAAGFASPSALLKHELAYCLGQTANGAAIPYLTAVLEDTGEDAMCRHEAAEALGALGDVASLGVLKRFRDREGEEVVVTETCELAVERIEWENGEGKKAEKLRASDFSSVDPAPPTAQGQEEQTVEELGNALMDTSLPLFKRYRAMFALRDLASPPDLPTAVPAVLALAKGFADSSALFRHEIAFVFGQLAHPASIPALTEALSNTEEASMVRHEAAEALGSLGDEEGVEETLRKFLHDAEAVVRESVIVALDMAEYEKSNETEYALIPEAQGTA

Protein

Deoxyhypusine hydroxylase: LIA1

Gene

lia1

Protein

Deoxyhypusine hydroxylase

Organism

Aspergillus oryzae (strain ATCC 42149 / RIB 40)

Length

339 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

36.986 kDa

Sequence

MASSAVDQPEGVDETILTLRKVLVNESEPLARRFRALFSLKYIACLQPPTEKTLPAIQAIAAGFTSSSALLKHELAYCLGQTRNPDAVSYLLEVVKNTEQDAMCRHEAAEGLGALGFDTSLDVLKALRDDEKEEDVIRETCDIAVDRILWENSEERKSEKLKPSDFTSIDPAPPLPMASSQPSISDLEKTLLDTKLPLFQRYRAMFALRDLASPPDLPTAVEAVEALAKGLKDPSALFRHEVAFVFGQLCHPASVPSLTETLSDQKEMGMVRHEAAEALGSLGDVEGVEDTLKKFLNDPEQVVRDSIIVALDMAEYEKNGEMEYALVPDSAAPAAVSAA

Protein

Deoxyhypusine hydroxylase: lia1

Gene

lia1

Protein

Deoxyhypusine hydroxylase

Organism

Aspergillus niger (strain CBS 513.88 / FGSC A1513)

Length

338 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

36.899 kDa

Sequence

MSAVNENNLEGVSETVLTLRKVVVNESEPLARRFRALFSLKYLACLQPPSEDTLPAIEAIAAAFSSKSALLKHELAYCLGQTRNPDAVAFLQQVLKDKEEDVMCRHEAAEALGALGYEDSLEILKALKDDENEPEVIRETCDIAVDRIVWENSEARKAEKLKPSDFTSIDPAPPMPLEAAEPSIPELEKTLLDTKLPLFQRYRAMFALRDLASPPDLPTAVQAVDALAKGLKDPSALFRHEVAFVFGQLCHPASVPSLTECLSNQEEAGMVRHEAAEALGSLGDVEGVEDTLKKFLNDPEQVVRDSIIVALDMAEFEKNGEMEYALVPDSGAPAAVSA

Protein

Deoxyhypusine hydroxylase: lia1

Gene

LIA1

Protein

Deoxyhypusine hydroxylase

Organism

Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)

Length

337 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

36.535 kDa

Sequence

MSPSADTPEISNSADSTVLSLKKSLCSEDSPLPIRFRALFSLKHVATTADDDATRVAAIEAIAAGFASPSALLKHELAYCLGQTGNTAAVKPLRQVLSDLKEDPMCRHEAAEALGALGWADNLDILREYRDRKEEDISIVETCEIAIERIEWENSAERQKEKLRPSDFASIDPAPPMPESDKEAEVEDLGRKLMDTNADLFSRYRAMFALRDLASPPDLPTATPAVLALAKGLSDSSALFRHEIAFVFGQLSHPASIPALTEALSNTNEASMVRHEAAEALGSLGEKDGVEDTLRKFLHDKEKVVRESCIVALDIAEYEKGEDAEYALIPESAGAAA

Protein

Deoxyhypusine hydroxylase: LIA1

Gene

lia1

Protein

Deoxyhypusine hydroxylase

Organism

Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)

Length

336 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

36.666 kDa

Sequence

MTTDNLNSADTTVQTLRNVLTSETEPLARRFRALFSLKHLACLQPPTEKTLPAIQAIAAGFSSASALLKHELAYCLGQTRNTDALPFLLDVVQDTQEDSMCRHEAAEALGALGYESSLEVLKALRDNENEVDVVRETCDIAVDRILWEQSEARKAEKLKPSDFTSIDPAPPMPLTAKEPSIPDLEKTLLDTNLPLFERYRAMFGLRDLASPPDLPTAKQAVQSLAKGMKDPSALFRHEIAFVFGQLCHPASVPSLTETLSDLNEVGMVRHEAAEALGSLGDVEGVEDTLKKFLNDPEKVVRDSIIVALDMAEFEKNGEIEYALIPDSGNPAAVPAA

Protein

Deoxyhypusine hydroxylase: lia1

Gene

lia1

Protein

Deoxyhypusine hydroxylase

Organism

Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)

Length

335 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

36.482 kDa

Sequence

MSPSATDTTEGVDPTILTLRKVLTSESEPLARRFRALFSLKHLACLQPPTEKTLPAIQAIAAAFTSPSALLKHELAYCLGQTRNPESVPFLQQVAKDTEQDTMCRHEAAEALGALGYEDSLEILKALRDNQNESDVIRETCDIAVDRILWENSEARKAEKLKTSDFTSIDPAPPLPMTASEPSIPEIEKTLLDTSLPLFLRYRAMFALRDLASPPDLPTATRAVEALAKGLKDPSALFRHEIAFVFGQLCHPASIPSLTEALSNQSEAGMVRHEAAEALGSLGDCEGVEETLRKFLNDPEQVVRDSVIVALDMAEYEKNGEVEYALVPDAGVAAA

Protein

Deoxyhypusine hydroxylase: lia1

Gene

lia1

Protein

Deoxyhypusine hydroxylase

Organism

Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)

Length

335 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

36.616 kDa

Sequence

MSPSATDNSDGPDATVLTLRKVLTSESEPLARRFRALFSLKYLACQQPATEKTLPAIQAIAAAFTSPSALLKHELAYCLGQTRNPESVPYLQEVVKDTEQDTMCRHEAAEALGALGYEDSLEILKVLRDNKDEPDVIRETCDIAVDRILWENSEQRKAEKLKASDFTSIDPAPPLPMATSEPSIPDIEKRLLDTSLPLFQRYRAMFALRDLASPPDLPTATHAVEALAKGLKDPSALFRHEIAFVFGQLSHPASIPSLTEALSDQNEVGMVRHEAAEALGSLGDCEGVEDTLKKFLNDPEQVVRDSVIVALDMAEYEKNGEIEYALVPDSGVAAA

Protein

Deoxyhypusine hydroxylase: lia1

Gene

lia1

Protein

Deoxyhypusine hydroxylase

Organism

Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)

Length

335 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

36.583 kDa

Sequence

MSPSATDTTEVMDPTILTLRKVLTSESEPLGRRFRALFSLKHLACLQPPTEKTLPAIQAIAAAFTSPSALLKHELAYCLGQTRNPASLPFLQQVAKDTEQDTMCRHEAAEALGALGYEDSLEILKALRDNQNEPEVIRETCDIAVDRILWENSEARKAEKLKTSDFTSIDPAPPLPMTASEPSIPEIEQTLLDTSLPLFLRYRAMFALRDLASPPDLPTATRAVEALAKGLKDPSALFRHEIAFVFGQLCHPASIPSLTEALSNQSEAGMVRHEAAEALGSLGDYEGVEETLRKFLNDPEQVVRDSVIVALDMAEYEKNGEVEYALVPDAGVAAA

Protein

Deoxyhypusine hydroxylase: lia1

Gene

LIA1

Protein

Deoxyhypusine hydroxylase

Organism

Coccidioides immitis (strain RS)

Length

335 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

36.599 kDa

Sequence

MASTIADNADNNGNSKDSVQYLRKVLTSESSPLAQRFRALFSLKHLASSKPPTEETLPAIEAIAAAFSSPSALLKHELAYCLGQTRNLDTVPHLRKVLEDTQEDAMCRHEAAEALGALGDAGSLAILQRLRDDESEEEVVRETCDIAVDRILWETSKDSKSEKLKQSDFTSIDPAPPLPLSSAEQSIPELKQILLDASLPLFKRYRAMFALRDMCSPPDLPTAVPAIEALAEGFKDRSALFRHEIAFVFGQLSHPASIPSLVATLSDKNEVGMVRHEAAEALGSLGAEDGVEETLKRFVNDPETVVRDSIIVALDMAEYEKSGEQEYILEQPVAA

Protein

Deoxyhypusine hydroxylase: LIA1

Gene

LIA1

Protein

Deoxyhypusine hydroxylase

Organism

Lentinula edodes

Length

330 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

36.124 kDa

Sequence

MSLSATQLKALEDSVLNTSGKVLLHDRVRALFTLKSLKNEDAIRIISKGFQDSAALLKHELAYCLGQIRNPLALPVLESVLRNPSEDPMVRHEAAEAMGAISTADSIPILKQYLSDPDRSVRETCEIAIAKIEWDKTEEGAKNDKATRDENRLPLYTSIDPAPATSGLLTGAPRPEEISQTKIDELRDNLLDVNRPLFERYRAMFALRNIGSPAAVDALAAGFSGDSALFKHEIAFVFGQLLSPHSVPCLIEVLQNSPESDMVRHEAAEALGGIATPEVLPPLKEWVARDDAPVVVRESCQVALDLWEYENSGDFQYANGLESPSTPISV

Protein

Deoxyhypusine hydroxylase: LIA1

Gene

LIA1

Protein

Deoxyhypusine hydroxylase

Organism

Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)

Length

329 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

35.71 kDa

Sequence

MAVTEQDTQVPTLRKIVTSESEPLARRFRALFSLKHLASLQPPTEQTVPAIEAIAAAFSSPSALLKHELAYCLGQSGHDAAIAPLRGVLEDKDEDSMCRHEAAEALGALSDKGSLELLKKMRDDANEVDVVRETCDIAVDRIEWEHGLQKGTEKLKKSDFTSVDPAPPMPESNEAPSIPALEKTLLDTTLPLFQRYRAMFALRDLSSPPDLPTAVPAVHALARGFGDPSALFRHEIAFVFGQLSHPASIPSLTEALSNTKEASMVRHEAAEALGSLGDEEGVEETLKKFLNDPEQVVRDSVIVALDMAEFEKNGEVEYAIVPQAQAIAA

Protein

Deoxyhypusine hydroxylase: LIA1

Gene

LIA1

Protein

Deoxyhypusine hydroxylase

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Length

325 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

36.165 kDa

Sequence

MSTNFEKHFQENVDECTLEQLRDILVNKSGKTVLANRFRALFNLKTVAEEFATKPEEAKKAIEYIAESFVNDKSELLKHEVAYVLGQTKNLDAAPTLRHVMLDQNQEPMVRHEAAEALGALGDKDSLDDLNKAAKEDPHVAVRETCELAINRINWTHGGAKDKENLQQSLYSSIDPAPPLPLEKDATIPELQALLNDPKQPLFQRYRAMFRLRDIGTDEAILALATGFSAESSLFKHEIAYVFGQIGSPAAVPSLIEVLGRKEEAPMVRHEAAEALGAIASPEVVDVLKSYLNDEVDVVRESCIVALDMYDYENSNELEYAPTAN

Protein

Deoxyhypusine hydroxylase: LIA1

Gene

lia1

Protein

Deoxyhypusine hydroxylase

Organism

Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)

Length

324 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

35.327 kDa

Sequence

MSATIASLRESLCSETTPLPIRFRALFSLKHLAVQNKGTADSLSAIDAIAAAFASPSALLKHELAYCLGQTGSDAAIPHLTQVLEDLQEDPMCRHEAAEALGALGKAESLGVLQKYLHREGEDVSVKETCEIAIDRIEWENSEERKQEKLRQSDFASVDPAPPMPEDDEKQTVETLEKKLLDTSLPLFKRYRAMFALRDLASPPDLPTAVPAILALAKGLKDESALFRHEIAFVFGQLSHPASIPALTEALSNLDEVSMVRHEAAEALGSLGDEEGVEETLLKFLHDKEKVVRESVIVALDMAEFEQSGQAEYALIPEVASKAS

Protein

Deoxyhypusine hydroxylase: lia1

Gene

LIA1

Protein

Deoxyhypusine hydroxylase

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)

Length

322 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

36.056 kDa

Sequence

MSTEFEKKMEEHIDSCSLEQLRDILVNKNGDAKLTNRFRALFNLKCVAEEFAQRPEEAQRAVEYICEAFADSSELLKHEVAYVLGQTGNLACAATLREVMLDHAQQCMVRHEASEALGALGDAASLGALERSRREDPSEEVRQTSELAIERIRWQASGAAATEQLQQSLYSSVDPAPPLSLEKDYDVPQLQALLNDQRAPLFERYRAMFRLRDIGSDEACYALASGFDDPSALFKHEIAYVFGQIGNPCVVPHLQEVLKREHEAPMVRHEAAEALGSIATDDVLPVLKRHLQDKDEVVRESAAIALDMYDYENSNELEYAPA

Protein

Deoxyhypusine hydroxylase: LIA1

Gene

LIA1

Protein

Deoxyhypusine hydroxylase

Organism

Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)

Length

322 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

35.97 kDa

Sequence

MSTNFEKHFEENVDDCNLEQLRDILVNKEGKSALANRFRALFNLKTAASEFEANPSDAEKAVQYMGETFGDNSELLKHEVAYVLGQTKNLKAAPLLRKTMLDLAQQPMVRHEAAEALGALGDKDSLEDLEKCLKNDPHVAVRETCELAIARINWQHSDAPTKESLQQSLYSSIDPAPPLALEKEYDLEELKKLLNDQEKPLFLRYRAMFRLRDIGTDEAVLALASGFNDPSALFKHEIAYVFGQMGSTAAVPSLTEVLGRKEEAPMVRHEAAEALGAIASEDALPILKQYLNDEVDVVRESAIVALDMWEYENSNELEYAPA

Protein

Deoxyhypusine hydroxylase: LIA1

Gene

LIA1

Protein

Deoxyhypusine hydroxylase

Organism

Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)

Length

322 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

36.359 kDa

Sequence

MSTNFEKHFEVDVDNCSLEQLRDILVNNSGKAPLANRFRALFNLKGHAEEFASKPEDALKATQYLAEAFGDESELLKHEVAYVLGQTKNMAGAPLLRDVLADDKQQCMVRHEAAEALGALNDVDSLDILEKYFKEDPLLEIRQTCELAIDRIKWETSEEGRREALQESLYSSIDPAPPFSLEKDYKIQELKDILNDQNRPLFERYRAMFRLRDIGNDEACLALASGFDDPSALFKHEIAYVFGQICNPVVVPHLKEVLARPEEAPMVRHEAAEALGSIATDDVLPVLKEHLKDSDSVVRESAIVALDMYEYENSNDLEYAPV

Protein

Deoxyhypusine hydroxylase: LIA1

Gene

lia1

Protein

Deoxyhypusine hydroxylase

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843)

Length

318 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

35.689 kDa

Sequence

MSSEPVPQAVIDELERVLVNLDKSNPLSFRYRALFSLNALAKKGDKRAVDAIYKAFIDDSELLKHEMAYVMGQSGQQYAVQPLINIVNDLDQQVMVRHEAAEALGALGFTESLPVLEKYYKEDPLAPIRETCELAIARIQWKNGLDKNNEKITPSMYDSVVDPAPPMPDHEQDVKSEVAKLRSEIVDQNLPLFYRYRVMFRLRNIGNEEAVLALTDGFKDPSPLFRHEIAFVFGQMIAPASVPALIKVLENTEEVPMVRHEAAEALGGIANDECLPVLKKFSKDDVRVVAESCIVALDMIEYEKSGDMEYAYIPKVSA

Protein

Deoxyhypusine hydroxylase: lia1

Gene

LIA1

Protein

Deoxyhypusine hydroxylase

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876)

Length

318 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

35.802 kDa

Sequence

MSADEVNIDTASLEELRDILINKTGNTKLANRFRALFNLKSVGSEDSDKERAHKAIKYIAECFNDDSELLKHEVAYVLGQTKDLYAAPYLREVLENDNQQCMVRHEAAEALGALGDKESLPLLEKYFKEDPLLEIRQTCELAIERIHWENSEKAKNEVLEKSLYTSIDPAPPLATNDSTSKVEKLKEILNDQDKPLFERYRAMFRLRDIGTDEACLALASGFDDPSALFKHEIAYVFGQMCNPVTVPSLIKVLKDESEAGMVRHEAAEALGSIATDECLPVLQSFLNDSEPVVRDSAIVALDMYEYENSNELEYATVK

Protein

Deoxyhypusine hydroxylase: LIA1

Gene

LIA1

Protein

Deoxyhypusine hydroxylase

Organism

Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)

Length

311 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

35.016 kDa

Sequence

MTEEINIDTATLEQLRDVLTNKSGDVKLANRFRALFNLKCVGAESENQDEVHKAIDYIAESFKDDSELLKHEVAYVLGQTKNLHAAQYLRSVLENNNQQIMVRHEAAEALGALGDKDSLALLEDYFKNDPSIEIKQTCELAIERIRWENSEKAKAENLETSLYTSIDPAPPMPSDQESKVEKLQKILNNQDEPLFERYRAMFRLRDMGTDEACLALASGLDDDPSALFKHEIAYVFGQLCNPVTVPALIKTLKDEREAAMVRHEAAEALGSIATDECLPVLQSFLNDKDQVVRDSAVVALDMYEYENSTEI

Protein

Deoxyhypusine hydroxylase: LIA1

Gene

LIA1

Protein

Deoxyhypusine hydroxylase

Organism

Yarrowia lipolytica (strain CLIB 122 / E 150)

Length

308 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

34.038 kDa

Sequence

MATETLPELKKVLLNEDGQTALALRFRALFSLKDMGEKGDNGAIDVIAEGFKDDSELLKHELAYVLGQTKNFHAVKPLQGVLADTNQQAMVRHEAAEALGALGDKGSVAMLQEYFENDPLEVIRETCELALERIKWENSEAAKTETLQKSAYTSIDPAPPLPTDQAEGSDKATVEKLQKTLMDKSQSLFHRYRAMFRLRDIGTEDAVLALATGFDDSSALFRHEIAYVFGQMSDPASVPALIKVLGKTEEEGMVRHEAAEALGSIATDDVLPILKKFAEDKDQVVRESAIVALDMYEYENSNEVEYAH

Protein

Deoxyhypusine hydroxylase: LIA1

Gene

LIA1

Protein

Deoxyhypusine hydroxylase

Organism

Encephalitozoon cuniculi (strain GB-M1)

Length

285 amino acids

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Mass

32.249 kDa

Sequence

MDIEVARKNIGCDSVSIAKRMRSLFYLRNVLLPESARAITEAFGSKSVLLKHEAAYVLGQMRMEESVRVLLDVLSDEDEDEIVRHEAGEALGNFRPREEIVEALRKYSNHPKKPISETCYLALMKLKDGSDIVSKFGSRDPALPMEGSFEEARRILLDKNECLYRRYQAMFYLRDLGTSAAIHALGKSMEDDSALFKHEVSFVFGQMRSRESIPYLIKGMEDEKEHGMVRHECAEALGAIGDDAALKALSKYLHDPCDILRESVEVAVDIHSYMTGDEIEYCNAE

Protein

Deoxyhypusine hydroxylase: LIA1