LGR6

Leucine-rich repeat-containing G-protein coupled receptor 6

967 amino acids

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.

Belongs to the G-protein coupled receptor 1 family.

104.298 kDa

MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGLAFASHV

Lgr6

Leucine-rich repeat-containing G-protein coupled receptor 6

967 amino acids

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal (By similarity).

Belongs to the G-protein coupled receptor 1 family.

104.267 kDa

MHSPPGLLALWLCAVLCASARAGSDPQPGPGRPACPAPCHCQEDGIMLSADCSELGLSVVPADLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNHIRHIPDYAFQNLTSLVVLHLHNNRIQHVGTHSFEGLHNLETLDLNYNELQEFPLAIRTLGRLQELGFHNNNIKAIPEKAFMGSPLLQTIHFYDNPIQFVGRSAFQYLSKLHTLSLNGATDIQEFPDLKGTTSLEILTLTRAGIRLLPPGVCQQLPRLRILELSHNQIEELPSLHRCQKLEEIGLRHNRIKEIGADTFSQLGSLQALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCAYGICASFFKTSGQWQAEDFHPEEEEAPKRPLGLLAGQAENHYDLDLDELQMGTEDSKPHPSVQCSPVPGPFKPCEHLFESWGIRLAVWAIVLLSVLCNGLVLLTVFASGPSPLSPVKLVVGAMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLGCQATGFLAVLGSEASVLLLTLAAVQCSISVTCVRAYGKAPSPGSVRAGALGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGRPAALGFAVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLWPSPRSPGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGQPPGLETYGFPSVTLISRHQPGATRLEGNHFVESDGTKFGNPQPPMKGELLLKAEGATLAGCGSSVGGALWPSGSLFASHL

lgr6

Leucine-rich repeat-containing G-protein coupled receptor 6

962 amino acids

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway. Upon binding to R-spondins (rspo1, rspo2, rspo3 or rspo4), associates with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal (By similarity).

Belongs to the G-protein coupled receptor 1 family.

105.933 kDa

MLVVLLILHAVSCAHSHGSPGAAVPVKQCPSACQCEEDGILLLVDCSEQGLSSVPTDLSPLTSYLDLSMNNISEIQPNAFRNLHFLSELRLSGNHLRHIPGPMLQGLYNLKVLMLQNNQLERLPSEDPWELPNLLSLRLDANLIMEVPARTLSGMRSLRHLWLDDNALTEIPVSALNDLSSLQAMTLALNRITLIPDYAFRNLSNLVVLHLHNNMIRTLGQNCFEGLHSLETLELNFNDLQEFPVAIRTLAKLQELGFHNNNIKAIPERAFVGNPLLQTIHFYENPIQFVGRSAFQFLPKLHTLSLNGATEIREFPDLKGTTSLQVLTLTRAGLTSLPYDLCHLLPKLKVLELSHNVIEELPSFYHCTSLQEIGLQHNLIKQIEMNTFQQLGSLRSLDLSWNSINSIHPDAFFSLQSLIKLDLTGNRLSNLPMTGLTSLTHLKLKGNMALSRSFGLEDFPNIRVIEMPYAYQCCVFGGCSSYRSASQWEEQMGSEEEDFQKKSPSLFPIHTDNNYDLDLEEFQLAIEESKLQTSIQCTPIPGPFKPCDNLFDSWVVRLGMWLISLVSLMGNSLLILTVFTSPSYLSPVKFIIGTISGANLLTGLCTGTLALVDARTFGEFALHGAQWEMGAGCRAVGFLSVLASEGSILFLTLAAVQCSVSVSCARAYGKSPSLGSVRAAAVACLALSLAVAALPLIGVGEYGATPLCMPSPLPDGEPSTLGFMVALIMMNSLCFLVITGTYIKLYWDLMKGDFDSIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLSLFPVSEEVVKSVVLVLLPLPASINPLLYLLFNPHFREDMRLLLSRAHLNHDRNLDSFVSVDTEKSSYDSTQALVSFATEADGVFESLSVPNPETVARFTCPPSVALIPCQMQMKPSTDRENTGENLIRSAPGLIAKEQEHIRSSGVDTQNGTSIFSGAYHSTGPSAHSQVFT