Protein
Protein limb expression 1 homolog
Organism
Drosophila melanogaster
Function
Component of the Fat (ft) signaling pathway that functions in normal development of various organs such as the wing and leg (PubMed:19710173, PubMed:21379328). In developing imaginal disks, involved in regulating both the protein levels and apical localization of ft and ds (PubMed:19710173). Involved in establishing planar cell polarity (PCP) along the anterior-posterior axis of the wing (the early Fz signaling event), probably by acting upstream of ds and ft to regulate Fz activity (PubMed:21379328).
Similarity
Belongs to the LIX1 family.
Sequence
MVYPEEPFWVLPTVTGFYEDRDYRVNVVEALQEFWQMKQSRGAELKNGALVIYESIPSNSQPYICFVTLPGGSCFGSFQNCPTKAEARRSSAKIALMNSVFNEHPSRRISDEFIQKAVQDARTSFKGTSQINEGTESGIGAFRFMLEANKGRTMLEFQELMTVFQLLHWNGSLKAMRERHCSRQEVVAHYSNRSLDDEMRSQMALDWIAREHDNPGVIRRELVLAERELETFRMAGRELRFPKEKKDILMIAHNQLGGSALNSATIDD