Protein
2-isopropylmalate synthase
Organism
Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6)
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Sequence
MRNAQKSSGMPFHRYTPFQDQITVEMPDRTWPDKVITKAPRWCAVDLRDGNQALIDPMSPARKMKMFDLLVRMGYKEIEVGFPSASQTDFDFVRQLIEGNHIPDDVTIQVLTQAREHLIERTYESLVGAKQAIVHLYNSTSVLQRRVVFNQDEDGILDIALQGARLCRKYEETLADTHITYEYSPESFTGTELEYAVRVCNAVADVFEASADRQVIINLPATVEMATPNVYADSIEWMSRHLHPREGIILSLHPHNDRGTGVAAAELGYMAGADRIEGCLFGNGERTGNVDLVTLGLNLFVQGIDPMIDFSDIDDVRRTVEYCNQLPVPERSPYGGDLVFTAFSGSHQDAIKKGFEALERDAAAAGKDVADVTWQVPYLPVDPKDLGRSYEAVIRVNSQSGKGGVAYLLKNEHSLDLPRRAQIEFSGVIQRRTDTVGGEVSGAQLWQIFQDEYLPSGKADGQWGRYSLGSVKTETDDDGGMTLHASLTVDGAQVSRTGTGNGPIAALLNILTQDGVDVRVLDYSEHALSEGGNAMAAAYVECAVGERVLWGVGIDANTSMSSLKAVISAVNRAIRDAQS