leu2B

Gene

leu2B

Protein

3-isopropylmalate dehydrogenase B

Organism

Aspergillus niger

Length

371 amino acids

Function

Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.

Similarity

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Mass

40.126 kDa

Sequence

MSGTRAYNILVLPGDGIGPEVMAEAIKVLRTFNSSSMQFHLQEELIGGISIDTHGHSVTQPVKDAAVAADAVLFAAVGGSKVDHIRRGLDGPEGGLLQVRKAMDIYANLRPCSVDVPSREIARDFSPFRQEVIEGVDFVVVRENCGGAYFGKKVEEENYAMDEWGYSTTEIQRIARLAAELALRHDPPWPVISLDKANVLASSRLWRRVVENTISVEYPQVKLVHQLADSASLIMATDPRVLNGVILADNTFGDMLSDQAGSLIGTLGVLPSASLDGLPHPGKQEKVRGLYEPTHGSAPTIAGKNIANPTAMILCVSLMFRYSFNMENEARQIEDAVRAVLDRGLRTPDLGGNSSTQEFGDAVVAALQGKY

Protein

3-isopropylmalate dehydrogenase B: leu2B