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let-49

Gene
let-49
Protein
Mediator of RNA polymerase II transcription subunit 7
Organism
Caenorhabditis briggsae
Length
258 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 7 family.
Mass
29.529 kDa
Sequence
MLPGFGATQTVSPFPNPPEYASAYTSDRIDNGSAPPPPHPLTEFKVFGEEYRLEEDVIAPLSTAGVEQYYVDKNNWKAEMKKLNRXIGAFFDLLEVLIRAPDHPARDKKMVDLHTIFINMHHLINEFRPVQARDSVRILQERQIDELTEICDDFREYLAHGREVVEDQFKMITGKLPPPPPPSDLTRVRMQNGALHRLIEVEKETEEDEEMKEDDEEKPSTSSSEGNQKTLRDMTKGHGPPSVVNLLARQLNEMELKK

Gene
let-49
Protein
Mediator of RNA polymerase II transcription subunit 7
Organism
Caenorhabditis elegans
Length
251 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for germ cell development and gonadal growth.
Similarity
Belongs to the Mediator complex subunit 7 family.
Mass
28.888 kDa
Sequence
MLPGFGAQTVSPFPNPPEYASAYTSDRINNGSAPPPPHPLTEFKVYGEEYRLEDDVIAPLKNAGVAELYKNKNNWKTEMKKLNRSAIVAFFDLVEILIRAPDHPMREEKMVDLHTIFINMHHLINEFRPVQARDSVRILQERQIEELSDICKDFKKYLRDGREVVDDQFQMIRGKLPAPPQPSELTRVKLQDGVLHMLQETEASDDVEMKEEEGSEYSKKKARLELLSREDGPPSVVHLLARQFHDISLKK