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legI

Gene
legI
Protein
N,N'-diacetyllegionaminic acid synthase
Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Length
334 amino acids
Function
Involved in biosynthesis of legionaminic acid (5,7-diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O-linkage to Ser/Thr. Catalyzes the condensation of 2,4-diacetamido-2,4,6-trideoxymannose with phosphoenolpyruvate (PEP) to give N,N'-diacetyllegionaminic acid.
Mass
37.091 kDa
Sequence
MKKTLIIAEAGVNHNGDLNLAKKLIEIAADSGADFVKFQSFKAKNCISTKAKKAPYQLKTTANDESQLQMVQKLELDLKAHKELILHAKKCNIAFLSTPFDLESVDLLNELGLKIFKIPSGEITNLPYLKKIAKLNKKIILSTGMANLGEIEEALNVLCKNGAKRQNITLLHCTTEYPAPFNEVNLKAMQSLKDAFKLDVGYSDHTRGIHISLAAVALGACVIEKHFTLDKNMSGPDHKASLEPQELKMLCTQIRQIQKAMGDGIKKASKSEQKNINIVRKSLVAKKDIKKGEIFSEGNLTTKRPANGISAMRYEEFLGKIATKNYKEDELIRE