lcdH

Gene

lcdH

Protein

L-carnitine dehydrogenase

Organism

Rhizobium sp

Length

497 amino acids

Function

Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine. Despite a high similarity to 3-hydroxyacyl-CoA dehydrogenases, cannot dehydrogenate 3-hydroxybutylate and 3-hydroxybutyl-CoA. Is probably involved in a L-carnitine degradation pathway that allows Rhizobium sp. YS-240 to grow on L-carnitine as the sole source of carbon and nitrogen.

Similarity

In the N-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.

Mass

54.474 kDa

Sequence

MSFITKAACVGGGVIGGAWVARFALAGIDVKIFDPHPEAERIIGEVMANAERAYAMLTMAPLPPKGKLTFCKSIEEAVEGADWIQESVPERLELKRGVITKIDAAARPDALIGSSTSGLLPSDLQSEMHHPERMFVAHPYNPVYLLPLVELVGGKKTSKATIERAMQGVEQIGMKGVVIAKEIEAFVGDRLLEALWREALWLIQDDICHTETLDNVMRYSFGMRWAQMGLFETYRIAGGEAGMRHFLAQFGPCLKWPWTKFTDVVDLDDALVEKIGAQSDAQAAGRSIRELERIRDENLVGIMHALKSGNGGEGWGAGKLLADFEAKLWANARKPEADLGDVKPLRILDTKVSAAWVDYNGHMTEHRYLQVFGDTSDGVLRLIGVDLDYVRDGHSYYTVETHIRNLGDEASGEALYSTCQILSSDEKRLHIFSTIYNAATNEAVATAEQMMLHVDSKAGKAVAAPEAVLSKLRAITEAHAQLQTPDGAGRFVGQKRA

Protein

L-carnitine dehydrogenase: lcdH

Gene

lcdH

Protein

L-carnitine dehydrogenase

Organism

Rhizobium meliloti (strain 1021)

Length

496 amino acids

Function

Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.

Similarity

In the N-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.

Mass

54.306 kDa

Sequence

MTTITKAACIGGGVIGGAWAARFALAGIDVNIFDPHPEAERIIGEVMANAERAYGMLTMAPLPPRGKFTFCRSIQEAVEGVDWIQESVPERLPLKRGVINEIDAAARPDALIGSSTSGLLPSDLQAEMKHPERMFVAHPYNPVYLLPLVELVGGRKTSPETIRRAEEAVAEIGMKGVVIAKEIEAFVGDRLLEALWREALWLIQDDICDTETLDDVMRYSFGMRWAQMGLFETYRIAGGEAGMRHFLAQFGPCLKWPWTKFTDVVDLDDALVEKIGAQSDAQAAGRSIRELERIRDENLVGIMHALKAGDGGKGWGAGKLLADFEKRLWEKGGSPSKSLDASGPLRLVDTKVNAAWVDYNGHMTEHRYLQLFGDTSDALLKVIGVDFAYVEAGHSYYTVETHIRHLGEAKLGQALYTTLQLLSSDEKRIHFFTRIHDAASGDVIATAEQMMLHVDAKAGKSVPAPAEVMAKLKPIAEGHAKLDAPDGAGRHVGQKR

Protein

L-carnitine dehydrogenase: lcdH

Gene

lcdH

Protein

L-carnitine dehydrogenase

Organism

Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)

Length

487 amino acids

Function

Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.

Similarity

In the N-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.

Mass

53.505 kDa

Sequence

MTTAAIIGGGVIGGGWAARFLLNGWDVRVFDPDPEAERKIGEVLANARRSLPGLSDMPLPPEGKLSFHADLGEAVTGAAWIQESVPERLDLKLKVYRSIQEACDPGAILGSSTSGFKPSELQEGALRPGQIVVTHPFNPVYLLPLIELVTTPENSPEMIERAKEIMRGLGQFPLHVRKEIDAHIADRFLEAVWREALWLVKDGIATTEEIDEAIRMGFGIRWAQMGLFETYRVAGGEAGMKHFMAQFGPCLSWPWTKLMDVPEFTDELVDLIAGQSDAQSGHHTIRELERIRDNNLVGMMRALKAQNWGAGAVLNKHDAALKPKALPDLDTADLTQPILTLSRAVPLDWTDYNGHMTESKYLEAFANSTDRFMEIIGCDADYIAAGGSYFTAETHIRHLDEAHAGARIRVETQMLLGQGKKLHLFHRMYEGDKLLATGESFLLHVSLETRKPCAPSPEIEAAMARIAEAQAGLSYPEGAGSAIRKPA

Protein

L-carnitine dehydrogenase: lcdH

Gene

lcdH

Protein

L-carnitine dehydrogenase

Organism

Agrobacterium fabrum (strain C58 / ATCC 33970)

Length

484 amino acids

Function

Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.

Similarity

In the N-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.

Mass

53.035 kDa

Sequence

MKIAAIGGGVIGGGWIARFILAGHDVTVFDPHPEANRIVTEVMANAAEAWGRLYQSPLPKPGSINWASSIAEAVAGADYIQESVPERLDLKHRIIAEIEATASPQAIIASSTSGFKPSELREGSVHSERVIVAHPFNPVYLLPVVEVVGGGVAAQRASDILVSVGMKPVQIGREIDAHIGDRLLEAIWREALWLVKDGIATTQEIDDIIRYGFGLRWAQMGLFETYRIAGGEAGMRHFLAQFGPALKWPWTKLMDVPEFNDELIDLIAGQSDAQSGAYSIRELERIRDSNLIGIFHALKANDWGAGQTVKAMENRFYARNGKVQADYPLRLHEAHVNGGWVDYNGHMTEFRYLQVLGDATDALLIHIGLDADYRAAGHSAYTVETHIRHLAEVKAGARLTVETRLLGYDDKRLRLHHAILNEDGETVATGEHMLLHVDTKANRTVAMPPALMRALDHLNAQEEGPLPDHAGSGIRAVRLKETSA

Protein

L-carnitine dehydrogenase: lcdH

Gene

lcdH

Protein

L-carnitine dehydrogenase

Organism

Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)

Length

364 amino acids

Function

Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.

Similarity

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.

Mass

39.788 kDa

Sequence

MSIINKAAAIGGGVIGAGWVARLLLNGIDVSIFDPDPEASRKVSEVMKGARRAYKQMVPGGLPKEGKLTFAKTIAEAVADADFIQESVPERLDLKHRVLAEIDAHAPANAIVGSSTSGIKPTDMQVAMKKHPERLVVGHPFNPVYLLPLVEIVGGDQTFPEAIEVAKEIYASIGMKPVVIRKEIEAFVGDRLLEAAWREALWLIKDGICTVEELDDIMRYGFGLRWAQMGMFQVYRVAGGEAGMRHFMAQFGPCLKWPWTKLMDVPEFNDELVDLIATQSDDQAHGLSIRELEKIRDDNLVAIMDALSKQNKGKGWGAGALHKDYTKQLAKLAAKKPAASTAAEKAKASKPVKKAEKPKKKKKG

Protein

L-carnitine dehydrogenase: lcdH

Gene

lcdH

Protein

L-carnitine dehydrogenase

Organism

Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)

Length

335 amino acids

Function

Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.

Similarity

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.

Mass

35.227 kDa

Sequence

MTVTPSAATTDGPAAPCAPEDVRRVACVGTGVIGGGWAAHFLARGYDVTAWDPAPDAAVRLRRLIAAAWPALEQLGLAEGASQDRLTVTSTLEEAVADAQFVQESAPEKLDLKRDLLARLDAATPAGTVIASSTSGYPMTDMQTEAADPGRLVVGHPFNPPYLIPLVEVVGGVRTAPAAVDWAARFYAVAGKSVITMEREVPGFIANRLQEALWREALHMVANGEATVAEIDASITEGPGLRWAVMGPMLTFALAGGEGGMAHMLDHFGPSLTSPWTRLEAPELDRALYDAVVAGCEEAADGRSIADLVAERDRGVIDVLRATGRLPRSAEEAAR

Protein

L-carnitine dehydrogenase: lcdH

Gene

lcdH

Protein

L-carnitine dehydrogenase

Organism

Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / CIP 107115 / JCM 7437 / KCTC 9190 / NBRC 14626 / NCTC 10488 / NRRL B-5397 / IMRU 509)

Length

329 amino acids

Function

Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.

Similarity

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.

Mass

35.126 kDa

Sequence

MTENARTTPEAVRTVACVGAGVIGGGWVAHFLGRGYRVVAWDPAPDAESRLRGLVSSAWPALEELGPAEGASMANLRVVDTLAEAVADADFVQESAPERLDLKIDLLAEIDAATPEGVVIASSTSGYSMSEMQVGARTPGRLVVGHPFNPPYLVPLVEVVGGERSERWAVDWASDFYRAAGKSVITMERELPGFIGNRIQEAAWREALHMVAEGEATVEQIDLAMTSGPGLRWAFFGPCLTFHLAGGEGGMAHMLDHFGPSLKSPWTRLEAPELTAGLRDRMVAGTDEVVAGRSTAELIAQRDRRLIAVARALEEVERAEAAERAGADA

Protein

L-carnitine dehydrogenase: lcdH

Gene

lcdH

Protein

L-carnitine dehydrogenase

Organism

Bacillus cereus (strain ZK / E33L)

Length

326 amino acids

Function

Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.

Similarity

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.

Mass

36.257 kDa

Sequence

MERLNNMGKNSIKKVTVVGTGVIGNGWISRFLSQGYDVVATDPAKNAEVRMRQSIENAWPALEKQGLAEGASKDRLTFELDLAKAVADADLIQENVPEREALKRRVLAEIDHFSKSEAIIASSTSGLKPSILQEDCQRPERVIVAHPFNPVYLIPLVEVIGGKDTSPETINISEQFYQSIKMKPLVISTEVEGHIADRLMEAIWREALHLINDGVATTEEVDAAIIYGPGLRWALMGPFLTLHLAGGEQGMRYMLEQFGPALKLPWTKLVAPELTNELANRVVEGCEAQTTGYSIKKLEQRRDEFLIELIQLLEKYWPGANLKGKL

Protein

L-carnitine dehydrogenase: lcdH

Gene

lcdH

Protein

L-carnitine dehydrogenase

Organism

Burkholderia mallei (strain ATCC 23344)

Length

321 amino acids

Function

Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.

Similarity

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.

Mass

34.897 kDa

Sequence

MAVITKIDTFAAIGAGVIGSGWVARALANGLDVLAWDPAEDAEMQLRANVENAWPALERAGLAPGASPARLHFVPTIEACVADADFVQESAPEREALKLELHERISRAAKPDAIIASSTSGLLPTDFYARAHRPERCIVGHPFNPVYLLPLVEVLGGERTAPDTVDAALGIYRALGMRPLRVRKEVPGFIADRLLEALWREALHLVDEGVATTGEIDDAIRFGAGIRWSFMGTFLTYTLAGGEAGMRHFMQQFGPALELPWTKLVAPKLTDALIDRVVEGTAEQQGPRSIKALERYRDECITEVIAAIAAVKARHGMRYED

Protein

L-carnitine dehydrogenase: lcdH

Gene

lcdH

Protein

L-carnitine dehydrogenase

Organism

Burkholderia pseudomallei (strain K96243)

Length

321 amino acids

Function

Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.

Similarity

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.

Mass

34.839 kDa

Sequence

MAVITKIDTFAAIGAGVIGSGWVARALANGLDVLAWDPAEGAEMQLRANVENAWPALERAGLAPGASPARLHFVPTIEACVADADFVQESAPEREALKLELHERISRAAKPDAIIASSTSGLLPTDFYARAHRPERCIVGHPFNPVYLLPLVEVLGGERTAPDTVDAALGIYRALGMRPLRVRKEVPGFIADRLLEALWREALHLVDEGVATTGEIDDAIRFGAGIRWSFMGTFLTYTLAGGEAGMRHFMQQFGPALELPWTKLVAPKLTDALIDRVVEGTAEQQGPRSIKALERYRDECITEVIAAIAAVKARHGMRYED

Protein

L-carnitine dehydrogenase: lcdH

Gene

lcdH

Protein

L-carnitine dehydrogenase

Organism

Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

Length

321 amino acids

Function

Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine. Is specific for L-carnitine and NAD(+) as substrates. D,L-3-hydroxybutyrate, L-lactate, ethanol, L-malate and D,L-isocitrate are not substrates. Is involved in a L-carnitine degradation pathway that allows P.aeruginosa to grow on L-carnitine as the sole source of carbon and nitrogen.

Similarity

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.

Mass

34.695 kDa

Sequence

MSFVTEIKTFAALGSGVIGSGWIARALAHGLDVVAWDPAPGAEAALRARVANAWPALRKQGLAPGAAQERLRFVASIEECVGDADFIQESAPERLDLKLDLHARISAAARPDVLIGSSTSGLLPSEFYAEASHPERCLVGHPFNPVYLLPLVEVVGGERTAAEAVRAAMRVYESLGMRPLHVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGLRWSFMGTFLTYTLAGGNAGMRHFMAQFGPALQLPWTYLPAPELTEALIDRVVEGTAEQQGARSIAELERYRDDCLLAVLGAIRETKARHGFAFAE

Protein

L-carnitine dehydrogenase: lcdH

Gene

lcdH

Protein

L-carnitine dehydrogenase

Organism

Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

Length

321 amino acids

Function

Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.

Similarity

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.

Mass

34.618 kDa

Sequence

MPFITEIKTFAALGSGVIGSGWVARALAHGLDVVAWDPAPGAEQALRKRVANAWPALEKQGLAPGASQDRLKFVATIEECVRNADFIQESAPERLDLKLDLHAKISAAAKPDAIIGSSTSGLLPSEFYESSTHPERCVVGHPFNPVYLLPLVEIVGGSRTSPEAIEAAKTIYTALGMRPLHVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGLRWSFMGTFLTYTLAGGDAGMRHFMSQFGPALKLPWTYLPAPELTDKLIDDVVSGTSEQQGERSIAALERYRDDTLLAVLEAVKSSKASHGLSFSD

Protein

L-carnitine dehydrogenase: lcdH

Gene

lcdH

Protein

L-carnitine dehydrogenase

Organism

Pseudomonas sp

Length

321 amino acids

Function

Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine. Is specific for L-carnitine and NAD(+) as substrates since D-carnitine, other carnitine analogs such as choline and betaine, and NADP(+) are not substrates. Despite a high similarity to 3-hydroxyacyl-CoA dehydrogenases, cannot dehydrogenate 3-hydroxybutylate and 3-hydroxybutyl-CoA. Is probably involved in a L-carnitine degradation pathway that allows Xanthomonas translucens to grow on L-carnitine as the sole source of carbon and nitrogen.

Similarity

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.

Mass

34.755 kDa

Sequence

MPFITHIKTFAALGSGVIGSGWVARALAHGLDVIAWDPAPGAEQALRQRVANAWPALEKQGLAAGAAQHRLSFVSSIEECVRDADFIQESAPERLDLKLDLHAKISAAAKPDAIIASSTSGLLPSEFYESSSHPERCVVGHPFNPVYLLPLVEIVGGRHTAPEAIEAAKGIYTELGMRPLHVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGLRWSFMGTFLTYTLAGGDAGMRHFMQQFGPALKLPWTYLPAPELTERLIDEVVDGTAAQVGERSIAELERYRDDTLLAVLEAIGTSKAKHGMTFSE

Protein

L-carnitine dehydrogenase: lcdH

Gene

lcdH

Protein

L-carnitine dehydrogenase

Organism

Staphylococcus epidermidis (strain ATCC 12228)

Length

321 amino acids

Function

Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.

Similarity

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.

Mass

35.774 kDa

Sequence

MKFAVVGTGVIGSGWITRMLAHGHEVIATDPSEGAYERMLTQVKQNWPYAEQMGLAENASIQNLTFTPHLEEAVKDADHIQENVPEVEEIKDAVLKEIDFYAKPEATIGSSTSGIMPSELQANLSHPERLVVAHPFHPVYILPLVEIVPGKQTSEETTVKAEQIYESIGMDVLHVRHEIEGHIADRLMEALWRESLHIVNDGIATTEEVDKAFTHAAGLRYAQYGPFMTFHLAGGEGGMRHMLKQFGPALKKPWTKLIAPELTDDLYHKVVSGSEASSQGYTMSELDQKRNEFLIKVKELAEQYWPSDSKAMKKSNGAELQ

Protein

L-carnitine dehydrogenase: lcdH

Gene

lcdH

Protein

L-carnitine dehydrogenase

Organism

Pseudomonas syringae pv. syringae (strain B728a)

Length

318 amino acids

Function

Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.

Similarity

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.

Mass

34.339 kDa

Sequence

MSFITEIKTFAALGSGVIGSGWVSRALAHGLDVVAWDPAPGAEAALRNRVAKCWGALEQQGLVPGASQNRLRFVATVEECVRDADFIQESAPERLELKLDLHSRISAAARSNVLIGSSTSGLLPSDVYESSAHPERCVVGHPFNPVYLLPLVEVVGGKNTAPAAIQAAIKVYESLGMRPLHVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGLRWSFMGTFLTYTLAGGEAGMRHFMTQFGPALQLPWTYLPAPELTDKLIDDVVDGTTDQLGKHSISGLERYRDDCLLAVLEAVKTTKARHGMA

Protein

L-carnitine dehydrogenase: lcdH

Gene

lcdH

Protein

L-carnitine dehydrogenase

Organism

Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

Length

318 amino acids

Function

Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.

Similarity

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.

Mass

33.922 kDa

Sequence

MTSPENVRRVACVGAGVIGGGWVAHFLARGYEVTAWDPAPDAEPRLRRLVEAAWPTLTRLGLAEGASTDRLTVTDTLEQAVADAEFVQESAPEKLDLKRDLLARLDAATPPGVVIASSTSGYPMTDMQTTAADPSRLVVGHPFNPPYLIPLVEVVGGERTAAAAVAWASRFYEVAGKSVITMDNEVPGFIANRLQEALWREALHMVASGEATVRDIDLSITEGPGLRWAVMGPMLTFALAGGEGGMAHMLDHFGPSLKSPWTRLAAPELDKELYDAVVAGCDEAADGRSIADLVAERDRGVVEVLRATGRLGPEEDSR

Protein

L-carnitine dehydrogenase: lcdH

Gene

lcdH

Protein

L-carnitine dehydrogenase

Organism

Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)

Length

307 amino acids

Function

Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.

Similarity

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.

Mass

34.183 kDa

Sequence

MKKVAVIGTGVIGNGWITRFLANGCEVVAHDPAPGAKERTIQAIENAWESVEQLGLKEGASKDSLTFVDSIEEAVKDADLIQESVPERYELKHGVLKEIDRFAHSNTIIGSSTSGIKPTDLQIGLNHPERLVVAHPFNPVYLLPLVEIVGGEATTKEITNRASVYYESLQMKPMVIEKEIEGFVADRLMEALWREALHLVNDGIATTEEVDKAITYGAGLRWAQMGPFMTFHLAGGNAGMRHMLEQFGPALKLPWTKLEAPELTDELKERVIQGCETHANDRSVEELEKKRNEFLVKLIDLVEDYWP

Protein

L-carnitine dehydrogenase: lcdH